Lopes Lab

Coeli Lopes, Ph.D.

Research Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute

 

1997 | PhD | Biophysics | Imperial College | UK

 

1992 | MS | Physics | Brazil-Pontificia Universidade Catolica

 

1989 | BS | Physics | Brazil-Pontificia Universidade Catolica

Coeli Lopes
Lopes profile

Research Overview

The major focus of Dr. Lopes' current work involves the regulation of the slow delayed rectifier-like current (IKs) in the heart and the pathogenesis of the Long QT (LQT1) syndrome. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization.

Projects

The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Stress and exercise are triggers known to precipitate arrhythmias, in particular for LQT1 patients. Dr. Lopes research focus on the understanding of the regulation of IKs channels, their importance for heart function and the molecular mechanism by which their down-regulation leads to the LQT1 syndrome.

In addition, Dr. Lopes is interested in phospholipid regulation of ion channels. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important membrane-delimited second messenger. It has been shown to be crucial for the activity of a number of transporters and ion channels. Several PIP2-sensitive channels have also been show to be regulated by physiological changes in PIP2 levels in the plasma membrane. Dr. Lopes is interested in the study of the crosstalk of PIP2 modulation with other common regulatory mechanisms of different ion channel families such as mechanosensitivity, voltage-gating and phosphorylation.

See our recent article, "Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients"   published in Science Translational Medicine.
http://stm.sciencemag.org/cgi/content/abstract/3/76/76ra28?ijkey=EICEykZC8IOP.
&keytype=ref&siteid=scitransmed

Recent Publications

  1. Adrenergic Signaling Controls RGK-Dependent Trafficking of Cardiac Voltage-Gated L-Type Ca2+ Channels Through PKD1., Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG., Circ Res. 2012 Jan 6;110(1):59-70.
  2. Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome. Goldenberg I, Thottathil P, Lopes CM, Moss AJ, McNitt S, O-Uchi J, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Barsheshet A., Heart Rhythm. 2012 Jan;9(1):49-56. Epub 2011 Aug 24.
  3. Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation., Barsheshet A, Moss AJ, McNitt S, Polonsky S, Lopes CM, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Kaufman ES, Towbin JA, Vincent GM, Qi M, Goldenberg I., Circ Cardiovasc Genet. 2011 Oct;4(5):491-9.
  4. Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients., Jons C, O-Uchi J, Moss AJ, Reumann M, Rice JJ, Goldenberg I, Zareba W, Wilde AA, Shimizu W, Kanters JK, McNitt S, Hofman N, Robinson JL, Lopes CM., Sci Transl Med. 2011 Mar 30;3(76):76ra28.
  5. Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome., Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I.

More papers:PubMed

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Contact

Coeli Lopes, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box CVRI
Rochester, New York 14642
Admin. Office: (585) 276-9800
email

Lab Members

Elsa Ronzier

Elsa Ronzier

Postdoctoral Research Associate

Xiaorong Xu Parks

Xiaorong Xu Parks

Senior Project Research Associate