Alice P. Pentland, M.D. James H. Sterner Professor of Dermatology Professor and Chair, Department of Dermatology Alice_Pentland@urmc.rochester.edu

Dr. Pentland's Research

Dr. Alice Pentland is an expert in photobiology and skin cancer. She has also served as principal investigator on two investigator initiated and several company sponsored clinical trials. Since becoming chair, she has dedicated herself to bringing state-of-the-art technology to support individual health, with a personal focus in the field of Dermatology. To accomplish this, a rich interdisciplinary intellectual environment has been created in the department. Partners from many specialties in medicine, engineering, psychiatry, chemistry, computer science and optics are working together so that a broad platform takes shape on which this health care future can be built. The Department of Dermatology at the University of Rochester is the national center of such activities.

Education

Post-Doctoral Training

Academic Appointments and Professional Experience

Honors, Awards and Societies

• NIH RO1 AR46828 5/1/00-4/30/05
• NIH/NIAMS 2T32AR07472 5/1/99-4/30/04
• NCI Searle 9/1/00-9/15/02
• Monsanto 1/1/99-12/31/01
• NIH RO1 AR01849 7/1/90-6/30/00
• Keck Foundation Award, "Center for Future Health"
• NIH Program Project 5PO1DK38111-02, 12//86 - 11/30/96
• NIH RCDA KO4ARO1849, 7/1/90 - 6/30/95
• Veterans Administration Research Grant 1/97-1/2000
• Diplomate, American Academy of Dermatology, 1983
• Society for Investigative Dermatology
• American Academy of Dermatology
• American Dermatology Association
• American Society of Clinical Investigators 1991-1992
• Editorial Board - Journal of Investigative Dermatology
• Member - Dermatology Foundation Grant Review Board, 1990-1993
• Member of GMA-1 Study Section, October 1994-October 1998
• Board of Scientific Counselors National Cancer Institute 2001-2004
• Board of Directors, Society for Investigative Dermatology
• President-Elect, Society of Investigative Dermatology 2004-2005

References:

1. Pentland AP, Mahoney M, Jacobs SC, Holtzman MJ. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema. J Clin Invest. 86(2):566-74. 1990.

2. Pentland AP. Morrison AR. Jacobs SC. Hruza LL. Hebert JS. Packer L. Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition. J Biol Chem. 267(22):15578-84, 1992.

3. Miller CC, Hale P, Pentland AP. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. J Biol Chem. 269(5):3529-33, 1994.

4. Sudbeck BD, Parks WC, Welgus HG and Pentland AP. Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem. 269:30022-30029, 1994.

5. Ruiz N, Wang B, Pentland A, and Caparon M. Streptolysin O and Adherence Synergistically Modulate Proinflammatory Responses of Keratinocytes to Group A Streptococci. Mol Microbiol 27:337-46, 1998.

6. Konger, R. Malaviya R, Pentland AP: Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes. Biochim Biophys Acta 1401:221-34, 1998.

7. Buckman SY, Koki AT, Edwards DA, Pentland AP. Immunohistochemical analysis of cyclooxygenase expression in human skin. Methods Mol Biol120:35-43, 1999.

8. Pentland AP, Schoggins JW, Scott GA, Khan KNM, Han R. Reduction of UV induced skin tumors in hairless mice by selective Cox-2 inhibition. Carcinogenesis 20:1939-44, 1999.

9. Buckman SY, Koki AT, Edwards DA, Pentland AP. Immunohistochemical analysis of cyclooxygenase expression in human skin. Methods Mol Biol 120:35-43, 1999.

10. Rys-Sikora KE, Konger RL, Schoggins JW, Malaviya R, Pentland AP: Coordinate expression of secretory phospholipase A 2 and cyclooxygenase-2 in activated human keratinocytes. Am J Physiol CellPhysiol 278:C822-C833, 2000.

11. Scott, G, Deng A, Rodriguez-Burford C, Seiberg M, Han R, Babiarz L, Grizzle W, Bell W, Pentland A: Protease activated receptor-2, a receptor involved in melanosome transport, is upregulated in human skin by ultraviolet irradiation J Invest Dermat 117:1412-20, 2001.

12. Pentland, A.P.: Cyclooxygenase Inhibitors for Skin Cancer Prevention: Are They Beneficial Enough? Arch of Dermat 138:823-24, 2002.

13. Konger, R.L., Scott, G.A., Ladenson, J.H., Landt, Y., and A.P. Pentland: Loss of the EP 2 Prostaglandin Receptor Results in an Invasive Epithelial Phenotype and Decreased Paxillin Expression. Am J Pathol. 161(6):2065-78, 2002.

14. Rys-Sikora, K.E., Pentland, A.P., and R.L. Konger. Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes. J Invest Dermatol 120(1):86-95, 2003.

15. Tripp, C.S., Blomme, E.A.G., Chinn, K.S., Hardy, M.M., LaCelle, P., Pentland, A.P.: Epidermal COX-2 induction following UV-irradiation; Suggested mechanism for the role of COX-2 inhibition in photoprotection. J Invest Dermat 121(4):853-861, 2003.

16. Pentland, A.P., Scott, G., VanBuskirk J.,Tanck, C., LaRossa, G., and Brouxhon, S.: Cyclooxygenase-1 Deletion Enhances Apoptosis but Does Not Protect Against Ultraviolet Light-Induced Tumors. Cancer Res. 2004 64: 5587-5591.

Book Chapters

1. Pentland AP. Metabolism of Arachidonic Acid in Skin. Dermatology in General Medicine: Fitzpatrick’s Dermatology in General Medicine, 4 th Ed, (McGraw-Hill), Chapter 37, 1993.

2. Pentland AP. Arachidonic Acid Metabolism: Fitzpatrick’s Dermatology in General Medicine, 5 th Ed, McGraw-Hill, 1998.

3. Pentland, AP and Pentland, Alex P. Inventing the Future - Tools for SelfHealth. In: Future of Health Technology, R. Bushko (ed), IOS Press, Amsterdam, pp. 19-25, 2002.

4. Pentland, AP. Eicosanoids. In: Dermatology in General Medicine. 6 th Ed., Freedberg, Eisen, Wolff, Austen, Goldsmith, Katz (eds), McGraw-Hill, Chapter 34, pp. 343, 2003.