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Department of Dermatology

Glynis A. Scott, M.D.

Associate Professor of Dermatology, Pathology and Laboratory Medicine and Pediatrics

Director: Dermatopathology Unit, Department of Dermatology

Glynis_Scott@urmc.rochester.edu

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Dr. Glynis Scott is an expert in melanocyte biology and dermatopathology. She serves as principal investigator on an NIH grant to study the process of melanocyte dendrite extension and melanosome trafficking. Dr. Scott is the director of the dermatopathology service, which includes over 8,000 skin specimens from the community and University clinic per year. Dr. Scott also directs the teaching activities for dermatopathology, which include bi-monthly sessions around a multi-headed microscope as well as a two week elective.

Education

InstitutionLocationDegree Year
McGill UniversityMontreal, Quebec B.S., Physiology1979
Albany Medical CollegeAlbany, NY M.D.1983

Post-Doctoral Training

1983-84 Assistant Resident in Internal Medicine
Albany Medical Center Hospital, Albany, NY
1984-86 Resident in Pathology(Anatomic)
Yale University School of Medicine, New Haven, CT
1986-87 Chief Resident in Pathology(Anatomic)
Yale University School of Medicine, New Haven,CT
1987-88 Fellow in Dermatopathology
Yale University School of Medicine, New Haven, CT
Professional Experience
1988-89 Assistant Professor of Pathology and Laboratory Medicine and Dermatology, University of Rochester, Rochester, NY
1989-94 Assistant Professor of Dermatology, Pathology and Laboratory Medicine and Pediatrics, University of Rochester, Rochester, NY
1989-present Director, Dermatopathology Unit, Department of Dermatology, University of Rochester, Rochester, NY
1994 Acting Chair of Dermatology, University of Rochester, Rochester, NY
1994-present Associate Professor of Dermatology, Pathology and Laboratory Medicine and Pediatrics, University of Rochester, Rochester, NY

Honors and Awards

1983Alpha Omega Alpha
1989 Brian Flanagan Annual Teaching Award, Department of Dermatology, University of Rochester, Rochester, NY
1996 Brian Flanagan Annual Teaching Award, Department of Dermatology, University of Rochester, Rochester, NY

Journal Articles

  1. Warshauer D, Scott G, Gottschalk A. Focal acute acalculus cholecystitis. Am J Roentgenology 149:505-506, 1987.
  2. Scott G, Rosai JR. Spindle cell hemangioendothelioma: A report of 7 cases. Am J Dermatopathol 10:281-288, 1988.
  3. Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 107:1611-1619, 1988.
  4. Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J. Paracrine stimulation of melanocytes by keratinocytes through basic fibroblast growth factor. Ann NY Acad Sci 548:180-190, 1988.
  5. Scott G, Chen KTK, Rosai JR. Pseudoepitheliomatous hyperplasia in Spitz nevi, Arch Pathol & Lab Med 113:61-63, 1989.
  6. McCarthy S, Scott G, Majumdar S, Thompson S, Shapiro B, Thompson S, Lange R, Gore J. Uterine junctional zone: MR study of water content and relaxation properties. Genitourinary Radiology 171:241-243, 1989.
  7. Goldminz D, Scott G, Klaus S. Penile basal cell carcinoma - Report of a case and review of the literature. J Am Acad Dermatol 20:1094-7, 1989.
  8. Lane AT, Scott GA, Day KH. Development of human fetal skin transplanted to the nude mouse. J Invest Dermatol 93:787-791, 1989.
  9. Mehta RL, Scott G, Sloand JA, Francis CW. Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis. Amer J Med 88(3):252-257, 1990.
  10. Lawson J, Scott G. Spindle cell hemangioendothelioma and enchondromatosis. Skeletal Radiology 19:158-162, 1990.
  11. Toome BK, Bowers K, Scott G. Diagnosis of cutaneous cytomegalovirus (CMV): A review and report of a case. J Am Acad Dermatol 24(5):860-867, 1991.
  12. Haake AR, Scott GA. Physiological distribution and differentiation of melanocytes in human fetal and neonatal skin equivalents. J Invest Dermatol 96:71-77, 1991.
  13. Scott G, Stoler M, Sarkar S, Halaban R. Localization of basic fibroblast growth factor mRNA in melanocytic lesions by in situ hybridization. J Invest Dermatol, 96:318-322, 1991.
  14. Fairley JA, Scott GA, Jensen KD, Goldsmith LA, Diaz LA. Characterization of keratocalmin, a calmodulin-binding protein from human epidermis. J Clin Invest, 88:315-322, 1991.
  15. Scott GA, Haake AR. Keratinocytes regulate melanocyte number in human fetal and neonatal skin equivalents. J Invest Dermatol, 97:776-781, 1991.
  16. Scott GA, Ryan DH, McCarthy JB. Molecular mechanisms of human fetal and neonatal melanocyte attachment to fibronectin. J Invest Dermatol, 99(6):787-794, 1992.
  17. Scott GA, Trepeta R. Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in pre-pubescent children: Report of two cases and review of the literature. Amer J Dermpath, 15(2) 139-45, 1993.
  18. Scott GA, Goldsmith LA. Homeobox genes: Skin development. A review. J Invest Dermatol, 101:3-8, 1993.
  19. Rippis G, Becker B, Scott G. Hypertrophic lichen planus in three HIV-positive patients: An histologic and immunological study. J Cutan Pathol 21:52-58, 1994.
  20. Scott GA, Ewing J, Ryan D, Abboud C. Stem cell factor regulates human melanocyte-matrix interactions. Pig Cell Res, 7:44-51, 1994.
  21. Tang J, Scott GA, Ryan DH. Subpopulations of bone marrow fibroblasts support VLA-4 mediated migration of B cell precursors. Blood, 82:3415-3242, 1993.
  22. Scott GA. Report of three cases of cutaneous reactions to GM-CSF and a review of the literature. Amer J Dermpath, 17:107-114, 1995.
  23. Zalka AD, Goldsmith LA, Scott, GA. Picture of the month: Monilethrix. Arch Ped Adoles Med, 149:549-550, 1995.
  24. Dimri GP, Lee X, Basile G, Accosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J. A biomarker that identifies senescent human cells in culture and in aging in vivo. Proc Natl Acad Sci 92(20): 9363-9367, 1995.
  25. Scott GA, Liang H. pp125FAK in human melanocytes and melanoma: Expression and phosphorylation. Exp Cell Res, 219:197-203, 1995.
  26. Scott GA, Liang H. Developmental regulation of focal contact protein expression in human melanocytes. Pig Cell Res, 8:221-228, 1995.
  27. Lazova R, Slater C, and Scott G. Reactive angioendotheliomatosis: Report of a case and review of the literature. Am J Dermpath, 18:63-69, 1996.
  28. Lu B, Scott G, Goldsmith LA. A model for keratinocyte gene therapy: Preclinical and therapeutic considerations. Proc Assoc Am Phys 108 (2): 165-172, 1996.
  29. Lasova R, Slater C, Scott G. Reactive angioendotheliomatosis: case report and review of the literature. Amer J Dermatopath 18(1):63-9,1996.
  30. Scott G, Liang H, Luthra D. Stem Cell Factor Regulates the Melanocyte Cytoskeleton. Pig Cell Res, 9:134-141, 1996.
  31. Stitt ZW, Scott GA, Martin RE, Gaspari AA. Multiple Chemical Sensitivities, Including Iatrogenic Allergic Contact Dermatitis, in a Patient With Chronic Actinic Dermatitis: Implications For Management. American J Contact Dermatitis 7(3):166-170, 1996.
  32. Zalka AD, Ryan AS, Worobec SM, Scott GA. Elastophagocytosis: A Clue To The Diagnosis Of GM-CSF-Induced Dermatosis. J Cut Med Surgery (in press), 1996.
  33. Scott GA, Cassidy L, Bussaco A. Fibronectin suppresses apoptosis in human melanocytes through an integrin-dependent mechanism. J Invest Dermatol 108:803-808, 1997.
  34. Lazova R, Moynes R, May D, Scott G. LN-2 (CD-74): A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer 79:2115-2124, 1997.
  35. Scott GA, Cassidy L, Abdel-Malek Z. Melanocyte stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation. Exp Cell Res 237:19-28, 1997.
  36. Lu B, Federoff HJ, Wang J, Goldsmith LA, Scott G. Topical applications of viral vectors for epidermal gene transfer. J Invest Dermatol 108:803-808, 1997.
  37. Scott GA, Cassidy L. Rac1 medicates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma mode. J Invest Dermatol 111:243-250, 1998.
  38. Stadler FJ, Scott GA, Brown MD. Malignant fibrous tumors. Seminars in Cut Med and Surg 17(2):141-152, 1998.
  39. Sankarasubbaiyan S, Scott G, Holley JL. Cryofibrinogenemia: an addition to the differential diagnosis of calciphylaxis in end-stage renal disease. Amer J Kidney Dis 32(3):494-8, 1998.
  40. Stitt WZ, Scott GA, Caserta M., Goldsmith LA. Coexistence of incontinentia pigmenti and neonatal herpes simplex virus infection. Ped Dermatol 15(2):112-115, 1998.
  41. Scott GA, Cassidy L, Tran H, Rao SK, Marinkovich MP. Melanocytes adhere to and synthesize laminin-5 in vitro. Exp Dermatol 8:212-221, 1999.
  42. Arin MJ, Longley MA, Epstein EH Jr., Scott G, Goldsmith LA, Rothnagel JA, Roop DR. A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens. J Invest Dermatol 112(3):380-2, 1999.
  43. Wang AR, May D, Bourne P, Scott G. PGP9.5: a marker for cellular neurothekeoma. Amer J Surg Pathol 23(11):1401-1407, 1999.
  44. Pentland AP, schoggins JW, Scott GA, Khan KN, Han R. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis 20(10):1939-1944, 1999.
  45. Stenn KS, Scott G: Whither dermatopathology (Letter) J Cutan Pathol 26(8):411-13, 1999.
  46. Suga Y, Arin MJ, Scott G, Goldsmith LA, Magro CM, Baen LA, Baden HP, Roop DR. Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens. Exp Dermatol 9(1):11-15, 2000.
  47. Ozog MD, Gogstetter DS, Scott G, Gaspari AA. Minocycline-induced hyperpigmentation in patients with pemphigus and pemphigoid. Arch Dermatol 136(9):1133-8, 2000.
  48. Gogstetter DS, Scott G, Gaspari AA. Periorbital mucinosis in discoid lupus erythematosus. CME self study 3(1)7-9, 2000.
  49. Gogstetter D, Brown M, Seab J, Scott G. Angiocentric primary cutaneous T-cell-rich B-cell lymphoma: a case report and review of the literature. J Cutan Pathol 27(10):516-25, 2000.
  50. Scott G, Deng A, Rodriguez-Burford C, Seiberg M, Han R, Babiarz I, Grizzle W, Bell W, Pentland A. Protease activated receptor-2 (PAR-2), a receptor involved in melanosome transport, is upregulated in skin in vivo by ultraviolet irradiation. J Invest Dermatol 117(6):1412-20, 2001.
  51. Scott G. Rac and Rho: The story of melanocyte dendrite formation (Review). Pigment Cell Research 15:1-9, 2002.
  52. Anadkat MJ, Cowen EW, Mercurio MG, Scott G. Disseminated bullous fixed drug eruption due to symphathomimetic medications. J Am Acad Dermatol. 49(5):E6, 2003.
  53. Scott G, Leopard S, Printup S, Madden B: Filopodia are a conduit for melanosome transfer. J Cell Sci. 115(Pt 7):1441-51, 2002.
  54. Konger RL, Scott GA, Landerson J, Landt Y, Pentland AP. Loss of prostaglandin E receptor subtype EP2 results in an invasive epithelial phenotype and decreased paxillin expression. Am J Pathol. 161(6):2065-78, 2002.
  55. Eva M. J. Peters, Markus Maurer, Vladimir A. Botchkarev, Karin deMasey Jensen, Desmond J. Tobin, Pia Welker, Martin Metz, Glynis A. Scott, and Ralf Paus. Kit is expressed by epithelial cells in vivo. J Invest Dermatol 121 (5): 976-984, 2003.
  56. Losee JE, Selber J, Vega S, Hall C, Scott G, Serletti JS. Primary Cutaneous Mucormycosis: Guide to Surgical Management. Annals of Plastic Surgery 49(4):385-90, 2002.
  57. Edward W. Cowen , Glynis A. Scott, Mary Gail Mercurio. Self-Healing Juvenile Cutaneous Mucinosis . J Am Acad Dermatol 50: S97-S100, 2004.
  58. Scott, G. Rac and Rho: the story of melanocyte dendrite formation (Review). Pigment Cell Research15 (5): 322-330, 2002.
  59. Scott G, Leopardi S. The cAMP-PKA signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cells. Pigment Cell Res. 16(2):139-48, 2003.
  60. Scott G, Leopardi S, Parker L, Babiarz L, Seiberg M, Han R. The proteinase activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes. J Invest Dermatol. 121(3):529-41, 2003.
  61. Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott, GA, Ryan C, Kobayashi I, Rossi TM, Goldsmith LA. Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Derm 140: 466-472, 2004.
  62. Conner SR, Scott G, Aplin AE. Adhesion –dependent activation of the ERK1/2 cascade is by-passed in melanoma cells. J Biol Chem. 278(36): 34548-54, 2003.
  63. Scott,G, Leopardi S, Printup S, Malhi N, Seiberg M, LaPoint R. Proteinase activated receptor-2 stimulates prostaglandin production in keratinocytes: analysis of prostaglandin receptors on human melanocytes and effects of PGE2 and PGF2 on melanocyte dendricity. J. Invest. Dermatology 122:1214-1224, 2004.
  64. Pentland AP, Scott G, VanBuskirk J, Tanck C, LaRossa G, Brouxhon S. Cyclooxygenase-1 Deletion Enhances Apoptosis But Does Not Protect Against UV-Induced Tumors. Cancer Res 64:5587-5591, 2004.

Book Reviews

  1. Scott G, Stenn KS. Pathobiology of malignant melanoma. Plastic and Reconstructive Surgery, 8:560, 1989.
  2. Scott GA. Atlas of Dermatopathology, by Rapini and Jordon: Arch Dermatol, 126(2):262, 1990.
  3. Scott GA. Pinkus' Guide to Dermatohistopathology (Fourth Edition), by Mehregan and Hashimoto. Arch Dermatol, 128(3):426, 1992.
  4. Scott GA, Brown MD. Malignant Skin Tumors (Second Edition), by Emmett and O'Rourke. N Engl J Med 325:1663-1664, 1991.
  5. Scott, GA. Differential Diagnosis in Dermatopathology III by A. Bernard Ackerman, Pedro L. Briggs, and Francisco Bravo: Arch Dermatol, 129(6):804, 1993. 

Book Chapters

  1. Scott G. Malignant Melanoma: Cell structure and function. In: Cutaneous Oncology: Pathophysiology, Diagnosis, and Treatment. Stanley J. Miller, M.D. and Maloney (eds.). Blackwell Scientific Co., Cambridge, MA, 1996.
  2. Scott G. "Histopathology of cutaneous cysts." In: Textbook of Dermatopathology. Raymond Barnill, M.D. (ed) McGraw-Hill Co., New York, NY, 1997
  3. Stadler FJ, Scott GA, Brown MD. "Malignant Fibrous Tumors" In: Seminars in Cutaneous Medicine and Surgery. Kenneth A. Arndth, Philip E. LeBiot, June K. Robinson and Bruce U. Wintroub (eds). W.B. Saunders Company, 1997.
  4. Haake A, Scott G, Holbrook K. "Structure and Function of the Skin" In: Biology of the Skin. David Woodley (ed). 2000.

Dr. Scott's Research
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