All we want to know is AR

George H. Whipple Laboratory for Cancer Research

Director - Dr. Chawnshang Chang (click here for publication PDF copies & CV)

chang's photo





The George H. Whipple Lab for Cancer Research was established in 1997 with the recruitment of Dr. Chawnshang Chang as the Founder and current Director. The lab is located in the University of Rochester Medical Center with 7 professors/principal investigators. The lab's interest is mainly in the sex hormones/nuclear receptors and Vitamin D/E effects on the prostate/bladder cancer and other hormones-related diseases.

Research Goals


A-AR molecular mechanisms

To dissect the molecular mechanism how androgen-AR functions.


A-AR physiological functions

ARKO mice with knockout AR in specific cell have been generated in our lab to study AR in vivo roles in bone, immunity and reproductive systems and tumors in liver, prostate, bladder, breast.


ER in vivo roles in Urology

We established a ERαKO and a ERβKO mice that knockout ERα or ERβ in specific cell to study ER roles in prostate, bladder and testis.


TR4 Nuclear Receptor

TR4 functions as transcription modulator with important in vivo roles in metabolism syndrome, fertility, aging and cancer


Vitamin D Receptor in Urology

To study the Vitamin D in vivo functions in prostate and bladder cancer.


Vitamin E in Urology

To study Vitamin E in vivo function in prostate and bladder cancer.