PI: Dr. Wen-Jye Lin

Jeff Lin's Portrait

Dr. Wen-Jye Lin

Research Assistant Professor of Pathology and Urology

Click here for CV.

Email: Wen-Jye Lin@urmc.rochester.edu

 

Dr. Wen-Jye Lin's lab

 

The Lin Laboratory is mainly focused on inflammatory signaling (NF-κB and STAT3) in prostate cancer initiation and progression, as well as characterization of roles of tumor-associated macrophages (TAMs) in this disease process. The role of the inflammatory signaling in prostate cancer development and progression is still very elusive, and a valuable mouse prostate tumor model is essential to define molecular events of inflammatory signaling that lead to the cancer initiation and progression.

Our laboratory is establishing two mouse prostate tumor models (PTEN+/- and TRAMP) as in vivo platforms to study the role of inflammatory signaling pathways, such NF-κB and STAT3 in the prostate tumorigenesis and cancer progression. Previous studies have shown inflammatory infiltrates are found in prostate cancer lesions. Using these two established tumor models, we can study how TAMs play a role in promoting prostate tumor development and progression.

 

Laboratory members

 

Wen-Jye Lin,  Ph.D., PI

Kouji Izumi, Ph.D., postdoctoral research fellow

Lei-Ya Fang, technical associate

 

Dr. Wen-Jye Lin's Publications (PDF files are available when you click individual publication)

  1. Lee YF. Young W-, Lin WJ, Shyr CR, and Chang C "Differential regulation of direct repeat 3 Vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor." J. Biol. Chem. (1999):274(23), 16198-205. PMID: 10347174.

  2. Lee YF, Shyr CR, Thin TH, Lin WJ and Chang C "Convergence of two repressors through heterodimer formation of androgen receptor and TR4 orphan nuclear receptor: a new signaling pathway in the steroid receptor superfamily." Proc. Natl. Acad. Sci. (1999):96(26), 14724-9. PMID: 10611280.

  3. Lin HK, Hu YC, Altuwaijri S, Lin WJ ,Kan PY, Collins L, and Chang C "Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells." J. Biol. Chem. (2002):277, 36570-6. PMID:12119296.

  4. Lee YF, Lin WJ, Huang J, Messing E, C Kuo, Wilding G, and Chang C "Activation of MAP kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor negative prostate cancer cells." Cancer Research (2002):62, 6039-44. PMID:12414626.

  5. Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH and Chang C "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." J. Biol. Chem. (2003):278, 9353-60. PMID:12522137.

  6. Yang Y, Wang X, Dong T, Kim E, Lin WJ and Chang C "Identification of a novel TR4 orphan receptor associated protein (TRA16) as repressor for the selective suppression of TR4-mediated transactivation." J. Biol. Chem. (2003):278, 7709-17. PMID:12486131.

  7. Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett L, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, and Chang C "Interruption of NFkB Signaling by Androgen Receptor Facilitates TPA-induce apoptosis in an Androgen Sensitive Prostate Cancer Cell Line." Cancer Research. (2003):63, 7106-12. PMID:146503.

  8. Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YY and Chang C "9-Cis-Retinoic Acid Inhibits Androgen Receptor Activity Through Activation of Retinoid X Receptor." Mol Endo. (2005):19(5):1200-12. PMID:15650026.

  9. Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW, Chang C. "Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth". Mol Endo. (2005):19(2):350-61. PMID:15514032.

  10. Chau H, Wong V, Chen NJ, Huang HL, Lin WJ, Mirtsos C, Elford AR, Bonnard M, Wakeham A, You-Ten AI, Lemmers B, Salmena L, Pellegrini M, Hakem R, Mak TW, Ohashi P, Yeh WC " Cellular FLICE-inhibitory protein is required for T cell survival and cycling". J. Exp. Med(2005).;202(3):405-13.

  11. Lin WJ, Yeh WC "Implication of Toll-like receptor and TNF-alpha Signaling in Septic Shock. Shock. (2005) ;24(3):206-9. PMID: 16135957

  12. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. "C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a". Nature(2007). 446(7132): 203-207

  13. Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF and Chang C "Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase-Mediated Gluconeogenesis" Diabetes (2007):56:2901-9. PMID:17827404.

  14. Chen NJ, Chio IC, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zúñiga-Pflücker JC, Wakeham A, Yeh WC, Mak TW. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. PNAS (2008); 105(34) :12431-12434

 

Contact us

For more information on the Lin Laboratory, please contact Dr. Lin at 585-273-4500 or Wenjye_Lin@urmc.rochester.edu.

 

Contact

Wen-Jye Lin
University of Rochester
Box 626
601 Elmwood Ave.
Rochester, NY 14642
+1-585-273-4500
Wen-Jye Lin@urmc.rochester.edu

Other PIs' Emails

Chawnshang Chang, Ph.D.

Chawnshang Chang, Ph.D.
Shu-Yuan Yeh, Ph.D.

Shu-Yuan Yeh, Ph.D.
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Hiroshi Miyamoto MD. PhD.
Soo OK Lee, Ph.D. Soo OK Lee, Ph.D.