Honors & News
February 13, 2015
Hoffman, Benoit Paper Published in Biomaterials
Graduate student, Michael Hoffman and the Benoit Lab have published a paper,
Emulating Native Periosteum Cell Population and Subsequent Paracrine Factor Production To Promote Tissue Engineered Periosteum-Mediated Allograft Healing, in the journal Biomaterials.
Emulating autograft healing within the context of decellularized bone allografts has immediate clinical applications in the treatment of critical-sized bone defects. The periosteum, a thin, osteogenic tissue that surrounds bone, houses a heterogeneous population of stem cells and osteoprogenitors. There is evidence that periosteum-cell derived paracrine factors, specifically vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP2), orchestrate autograft healing through host cell recruitment and subsequent tissue elaboration. In previous work, we demonstrated that the use of poly(ethylene glycol) (PEG) hydrogels as a tissue engineered (T.E.) periosteum to localize mesenchymal stem cells (MSCs) to the surface of decellularized bone enhances allograft healing and integration. Herein, we utilize a mixed population of 50:50 MSCs and osteoprogenitor cells to better mimic native periosteum cell population and paracrine factor production to further promote allograft healing. This mixed cell population was localized to the surface of decellularized allografts within degradable hydrogels and shown to expedite allograft healing. Specifically, bone callus formation and biomechanical graft-host integration are increased as compared to unmodified allografts. These results demonstrate the dual importance of periosteum-mediated paracrine factors orchestrating host cell recruitment as well as new bone formation while developing clinically translatable strategies for allograft healing and integration.
February 11, 2015
Danielle Benoit has received an NSF Faculty Early Career Development (CAREER) award for her proposal "Polymer therapeutics for bone regeneration: next-generation osteoporosis treatments."
Osteoporosis results from imbalances in bone production and resorption and affects roughly 14 million Americans. The majority of osteoporosis therapies reduce the activity of cells that resorb bone. Development of therapies targeted towards cells that produce new bone matrix may revolutionize osteoporosis therapies by offering an alternative to restore bone health, however, a critical technological gap exists in developing drug delivery approaches that provide specific treatment to bone. To overcome this challenge, Benoit's research seeks to develop drug delivery approaches to efficiently and specifically target anabolic drugs to bone to develop novel treatments for osteoporosis. Successful completion of this research will significantly advance therapeutic strategies for osteoporosis and the approaches developed will be readily adaptable to treat other bone diseases.
February 11, 2015
Jomy Varghese Receives Medical Faculty Council Travel Award in Basic Science Research
Benoit Lab graduate student, Jomy Varghese is a recipient of the Medical Faculty Council URSMD Trainee / Student Travel Award for Winter 2015 in Basic Science Research. The Medical Faculty Council is proud to be able to support his promising academic work by assisting with travel costs (up to a total of $1000) for his research presentation at a scientific conference. Congrats Jomy!
February 10, 2015
Benoit Lab Publishes Paper in Tissue Engineering
The Benoit Lab has published a new paper, entitled,
Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications, in the journal of Tissue Engineering, Part A.
February 9, 2015
Benoit Lab Publishes Article in ACS Nano
The Benoit Lab's article,
pH-activated Nanoparticles for Controlled Topical Delivery of Farnesol to Disrupt Oral Biofilm Virulencehas been published in ACS Nano. The authors of this work are Benjamin Horev, Marlise Klein, Geelsu Hwang, Yong Li, Dongyeop Kim, Hyun Koo, and Danielle Benoit.
January 12, 2015
Andrew Shubin Awarded Grant from National Cancer Institute
Andrew Shubin, a graduate student in Danielle Benoit's lab, was awarded an F30 grant from the National Cancer Institute (NCI) for his project titled
Poly(ethylene glycol) Hydrogels for Salivary Gland Regeneration.
Radiation for head and neck cancers causes severe damage to salivary glands resulting in permanent dry mouth. This issue greatly affects the quality of life for cancer survivors, as proper saliva production is essential for eating, speaking, and oral hygiene. This project aims to develop at 3D tissue engineering scaffold utilizing poly(ethylene glycol) hydrogels in order to regenerate salivary gland tissue to help treat this condition.
- Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels. J Biomed Opt. 20, 51024. (2015 May 01).
- pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence. ACS Nano. In press. (2015 Feb 13).
- Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential. J Biomed Mater Res A. In press. (2014 Dec 11).