Honors & News
October 15, 2008
New Five-Year NIH Grant to Study Ultrasound and Wound Healing Awarded to a Multi-Disciplinary Team of Engineers, Scientists, and Physicians
Diane Dalecki, Ph.D. (BME) and Denise Hocking, Ph.D. (Pharmacology and Physiology) are multi-PIs on a new, R01 NIH grant entitled "Mechanisms for Wound Healing with Ultrasound." The grant was awarded by the NIBIB for a five-year period. The overall goal of the project is to identify key biological and physical mechanisms for ultrasound-enhanced soft tissue wound healing in order to develop the use of ultrasound for chronic wound therapy. The guiding hypothesis of the work is that mechanical forces associated with ultrasound propagation are capable of triggering conformational changes to extracellular matrix proteins that in turn enhance cell growth and contractility, stimulate cellular migration, promote collagen organization and mechanical strength, and increase blood flow to tissues. The multi-disciplinary team of engineers, basic scientists, and physicians on the project are Ingrid Sarelius, Ph.D. (Pharmacology and Physiology), Sheryl Gracewski, Ph.D. (ME), Sabine Brouxhon, M.D. (Emergency Medicine), Charles Francis, M.D. (Medicine/Hematology), and Edwin Carstensen, Ph.D. (ECE).
December 1, 2007
RCBU Members Receive Grant to Develop Tool for Early Detection and Monitoring of Liver Disease
RCBU members Kevin Parker (PI), Robert Lerner, Stephen McAleavey, and Diane Dalecki received funding from the Stanford University Center on Longevity for the project titled,
Elastography in the Early Detection and Management of Liver Disease. The goal of this project is to develop a safe, non-invasive, inexpensive tool for the early detection and monitoring of liver disease.
September 24, 2007
NIH awards grant to study Ultrasound Technologies for Tissue Engineering
Diane Dalecki, Ph.D. and Denise Hocking, Ph.D., serve as multi-PIs on a grant from the NIH NIBIB titled
Ultrasound Technologies for Tissue Engineering. The overall goal is to develop ultrasound-based enabling technologies for the fabrication and monitoring of functional, 3D artificial tissues. Through the project, they will develop the use of ultrasound to regulate the structure and organization of the extracellular matrix in order to stimulate cell processes that are critical for engineering functional tissue constructs. Current studies are testing the ability of ultrasound to produce conformational changes in fibronectin, an extracellular matrix protein that plays key roles in regulating cell growth and migration. Working with co-investigators Stephen McAleavey, Ph.D. and Sheryl Gracewski, Ph.D., the team is also developing and applying new ultrasound imaging and tissue characterization techniques to noninvasively monitor the material and biological properties of engineered tissues, and to validate the measurements through mechanical testing and finite element modeling.
September 19, 2007
U.S. Navy Awards Grant to Study Neural Effects of Underwater Sound to John Olschowka, Ph.D. and Diane Dalecki, Ph.D.
John Olschowka (PI, Dept. of Neurobiology & Anatomy) and Diane Dalecki (co-I) received a two-year grant from the U.S. Navy titled
Neural Effects of Underwater Sound.Underwater sound fields are used for numerous commercial and military applications, including imaging, oil exploration, mapping the ocean, and harbor surveillance. Sponsored by the U.S. Navy, Drs. Olschowka and Dalecki have embarked on a new collaborative project that will investigate the interactions of continuous and impulsive underwater sound fields with the brain and spinal cord. The Olschowka lab, in the UR Department of Neurobiology and Anatomy, has long-standing expertise in examining injury to neural tissues, including trauma, using molecular, protein, and immunohistochemical techniques. Using the acoustic sources and technical expertise of the Dalecki lab, the team will investigate neural bioeffects of sound fields at frequencies ranging from 500 Hz-30 kHz. To also study the effects of acoustic impulses, the facilities and expertise available at Hydroacoustic, Inc. will be employed to generate underwater impulsive sound fields using an air gun system. Neural tissues of animals exposed to these continuous and impulsive underwater sound fields will be assessed for vascular damage, axonal injury, and glial activation. Results of this project will help to establish safe exposure guidelines for human divers and marine life exposed to underwater sound fields.
September 1, 2007
National Science Foundation awards grant to Study Dynamic Response of Constrained Bubbles to Acoustic Excitation
Sheryl Gracewski (PI) and Diane Dalecki (co-PI) were awarded an NSF grant from the CMMI division titled
Dynamic Response of Constrained Bubbles to Acoustic Excitation.This project will theoretically and experimentally characterize the linear and nonlinear dynamics of acoustically excited bubbles that are constrained within tubes and channels. The results of this work will be directly relevant to the use of ultrasound microbubble contrast agents in diagnostic imaging and new ultrasound-based therapies.
January 23, 2007
Diane Dalecki, associate professor of biomedical engineering, has been appointed the new director of the Rochester Center for Biomedical Ultrasound (RCBU) at the University of Rochester. Created in 1986, the RCBU provides a unique environment where researchers from many institutions can join together to investigate the use of very high frequency sound waves in medical diagnosis and therapy.
- Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A. 19, 2517-26. (2013 Nov 01).
- Controlling collagen fiber microstructure in three-dimensional hydrogels using ultrasound. J Acoust Soc Am. 134, 1491-502. (2013 Aug 01).
- Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields. J Acoust Soc Am. 134, 1483-90. (2013 Aug 01).