Honors & News
October 29, 2009
Dr. Diane Dalecki Elected Fellow of Acoustical Society of America
Diane Dalecki, Ph.D. (BME, RCBU) has been elected a Fellow of the Acoustical Society of America. She was recognized by the society for her
contributions to the bioeffects of sound and ultrasound.Professor Dalecki's election to Fellow was acknowledged at an awards ceremony during the 158th Meeting of the Acoustical Society of America that was held in San Antonio, TX on October 26-30, 2009.
October 1, 2009
New Collaboration between the Helguera (RIT), Dalecki, and Hocking Labs
A new collaboration, funded by the NIH, brings together the expertise of Professor Maria Helguera (Center for Imaging Sciences, RIT), Professor Diane Dalecki (BME, UR), and Professor Denise Hocking (Pharmacology & Physiology, UR). The collaborative effort focuses on developing novel, ultrasound tissue characterization techniques for engineered tissues. This work is part of a larger project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop ultrasound-based technologies for the field of tissue engineering.
Dr. Helguera's laboratory is devoted to advancing multimodal imaging and materials characterization techniques. Over the years, she has developed a suite of nondestructive, ultrasound-based materials characterization techniques for non-biological materials, such as polymers, ceramics, and layered materials. Through this new collaborative effort, the novel approaches that Dr. Helguera has developed and implemented for ultrasound characterization of non-biological materials will be translated to characterize the biological properties of engineered tissues. We propose to extend and apply high frequency ultrasound-based, tissue characterization techniques to monitor non-invasively biological and structural properties of cells and extracellular matrix proteins within three-dimensional engineered tissues. NIH support for the next two years will allow Dr. Helguera to spend the fall semesters and part of her summers devoted full-time to the research project as a Visiting Scientist in the Dalecki lab at the UR BME department. Drs. Helguera, Dalecki, and Hocking are all members of the Rochester Center for Biomedical Ultrasound.
June 30, 2009
Carol Raeman - 20 Years with the RCBU!
This month the RCBU recognizes Carol Raeman's 20 years of employment at the University of Rochester! Carol is currently a Technical Associate I working in the laboratory of Professor Diane Dalecki in the Department of Biomedical Engineering. Carol started her employment with the University in 1989 working with Professor Ed Carstensen in the Department of Electrical Engineering. During her early years of employment, Carol played a key technical role in many studies on the biological effects of lithotripter fields. Only one year after her initial hire, Carol was already a co-author on 5 papers dealing with the bioeffects of lithotripter fields and pulsed ultrasound on the kidney, chick embryo, and lung. As her career progressed, Carol contributed to many significant studies on the effects of ultrasound on tissues containing contrast agents, the mechanisms for ultrasound-induced lung damage, effects of ultrasound on the heart and neural tissue, and the interaction of very low frequency underwater sound with biological tissues. Recent areas of Carol's work include applications of ultrasound in wound healing and cell and tissue engineering.
Carol is highly skilled in both our biological and acoustic techniques, and contributes to the design and completion of a wide variety of research projects in our lab. Her experience, ingenuity, technical ability, and collaborative skills make her an enormously valuable member of our laboratory team. She has made outstanding contributions to the field of biomedical ultrasound over the years and we are very fortunate that she is a member of our lab.said Dr. Diane Dalecki.
June 16, 2009
Carlos Sevilla Awarded NIH Pre-doctoral Fellowship
Carlos Sevilla was awarded a prestigious NIH Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship. This three-year award will provide funding for Carlos' thesis research project, titled ,
Promoting Chronic Wound Healing with Ultrasound and Fibronectin. In his research, Carlos is investigating the ability of ultrasound to produce conformational changes in the extracellular matrix protein fibronectin that, in turn, stimulate cellular processes important for accelerating soft tissue wound repair. Carlos is a third year graduate student in the Department of Biomedical Engineering and his thesis research is co-advised by Dr. Denise Hocking and Dr. Diane Dalecki. Carlos is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Carlos' research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop the use of ultrasound for chronic wound therapy.
June 16, 2009
Drs. Hocking and Dalecki Receive NIH Funding for Summer Students
Dr. Denise Hocking and Dr. Diane Dalecki have received funding from the NIH to support the summer research projects and career development of undergraduate and high school students for two years. The funding is in response to American Recovery and Reinvestment Act (ARRA) initiatives of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Research areas of student projects focus on studying the effects of ultrasound on cell growth and protein conformation, and novel applications of acoustic radiation force. This work will contribute to a larger, multidisciplinary project, led by Drs. Hocking and Dalecki and funded by the NIH, that aims to develop novel ultrasound technologies for the field of tissue engineering.
June 5, 2009
Kelley Garvin Wins Best Student Paper Competition
Kelley Garvin won the Best Student Paper Competition at the 157th Meeting of the Acoustical Society of America held in Portland, OR from May 18-22. Her paper, titled
Ultrasound standing wave fields control the spatial distribution of cells and protein in three-dimensional engineered tissue,was recognized as the best student paper in the Biomedical Ultrasound / Bioresponse to Vibration Technical Section. Kelley presented her recent work demonstrating the use of ultrasound fields to non-invasively control the spatial locations of cells in collagen-based engineered tissues. Ultrasound standing wave fields were used to organize cells into planar bands within collagen gels, resulting in a significant two-fold increase in cell-mediated gel contraction, suggesting that ultrasound-induced cell organization leads to a differential extracellular matrix remodeling. Further, using ultrasound to spatially band endothelial cells within collagen gels resulted in vessel sprouting. These novel technologies have important applications to the fabrication of engineered tissues with desired tissue characteristics. Kelley is a third year graduate student in the Department of Biomedical Engineering (BME) and her thesis research is co-advised by Dr. Diane Dalecki and Dr. Denise Hocking. Kelley is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Kelley's research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop novel ultrasound technologies for the field of tissue engineering.
May 18, 2009
RCBU Members Attend Acoustical Society of America Meeting
The RCBU was well represented at the Meeting of the Acoustical Society of America held in Portland, Oregon on May 18-22, 2009, with the following presentations: Ultrasound Standing Wave Fields Control the Spatial Distribution of Cells and Protein in Three-Dimensional Engineered Tissue by Kelley A. Garvin, Denise Hocking, and Diane Dalecki. Kelley Garvin won the Best Student Paper Competition in the Biomedical Ultrasound/Bioresponse to Vibration Technical Section with this paper. Lung Hemorrhage Produced by Exposure to Underwater Acoustic Impulses by Diane Dalecki, Sally Z. Child, and Carol H. Raeman. Comparison of Unconfined Compression and Spatially Modulated Ultrasound Radiation Force Estimates of Shear Modulus by Stephen McAleavey, Erin Collins, Johanna Kelly, Etana Elegbe, and Manoj Menon.
October 15, 2008
New Five-Year NIH Grant to Study Ultrasound and Wound Healing Awarded to a Multi-Disciplinary Team of Engineers, Scientists, and Physicians
Diane Dalecki, Ph.D. (BME) and Denise Hocking, Ph.D. (Pharmacology and Physiology) are multi-PIs on a new, R01 NIH grant entitled "Mechanisms for Wound Healing with Ultrasound." The grant was awarded by the NIBIB for a five-year period. The overall goal of the project is to identify key biological and physical mechanisms for ultrasound-enhanced soft tissue wound healing in order to develop the use of ultrasound for chronic wound therapy. The guiding hypothesis of the work is that mechanical forces associated with ultrasound propagation are capable of triggering conformational changes to extracellular matrix proteins that in turn enhance cell growth and contractility, stimulate cellular migration, promote collagen organization and mechanical strength, and increase blood flow to tissues. The multi-disciplinary team of engineers, basic scientists, and physicians on the project are Ingrid Sarelius, Ph.D. (Pharmacology and Physiology), Sheryl Gracewski, Ph.D. (ME), Sabine Brouxhon, M.D. (Emergency Medicine), Charles Francis, M.D. (Medicine/Hematology), and Edwin Carstensen, Ph.D. (ECE).
December 1, 2007
RCBU Members Receive Grant to Develop Tool for Early Detection and Monitoring of Liver Disease
RCBU members Kevin Parker (PI), Robert Lerner, Stephen McAleavey, and Diane Dalecki received funding from the Stanford University Center on Longevity for the project titled,
Elastography in the Early Detection and Management of Liver Disease. The goal of this project is to develop a safe, non-invasive, inexpensive tool for the early detection and monitoring of liver disease.
September 24, 2007
NIH awards grant to study Ultrasound Technologies for Tissue Engineering
Diane Dalecki, Ph.D. and Denise Hocking, Ph.D., serve as multi-PIs on a grant from the NIH NIBIB titled
Ultrasound Technologies for Tissue Engineering. The overall goal is to develop ultrasound-based enabling technologies for the fabrication and monitoring of functional, 3D artificial tissues. Through the project, they will develop the use of ultrasound to regulate the structure and organization of the extracellular matrix in order to stimulate cell processes that are critical for engineering functional tissue constructs. Current studies are testing the ability of ultrasound to produce conformational changes in fibronectin, an extracellular matrix protein that plays key roles in regulating cell growth and migration. Working with co-investigators Stephen McAleavey, Ph.D. and Sheryl Gracewski, Ph.D., the team is also developing and applying new ultrasound imaging and tissue characterization techniques to noninvasively monitor the material and biological properties of engineered tissues, and to validate the measurements through mechanical testing and finite element modeling.
September 19, 2007
U.S. Navy Awards Grant to Study Neural Effects of Underwater Sound to John Olschowka, Ph.D. and Diane Dalecki, Ph.D.
John Olschowka (PI, Dept. of Neurobiology & Anatomy) and Diane Dalecki (co-I) received a two-year grant from the U.S. Navy titled
Neural Effects of Underwater Sound.Underwater sound fields are used for numerous commercial and military applications, including imaging, oil exploration, mapping the ocean, and harbor surveillance. Sponsored by the U.S. Navy, Drs. Olschowka and Dalecki have embarked on a new collaborative project that will investigate the interactions of continuous and impulsive underwater sound fields with the brain and spinal cord. The Olschowka lab, in the UR Department of Neurobiology and Anatomy, has long-standing expertise in examining injury to neural tissues, including trauma, using molecular, protein, and immunohistochemical techniques. Using the acoustic sources and technical expertise of the Dalecki lab, the team will investigate neural bioeffects of sound fields at frequencies ranging from 500 Hz-30 kHz. To also study the effects of acoustic impulses, the facilities and expertise available at Hydroacoustic, Inc. will be employed to generate underwater impulsive sound fields using an air gun system. Neural tissues of animals exposed to these continuous and impulsive underwater sound fields will be assessed for vascular damage, axonal injury, and glial activation. Results of this project will help to establish safe exposure guidelines for human divers and marine life exposed to underwater sound fields.
September 1, 2007
National Science Foundation awards grant to Study Dynamic Response of Constrained Bubbles to Acoustic Excitation
Sheryl Gracewski (PI) and Diane Dalecki (co-PI) were awarded an NSF grant from the CMMI division titled
Dynamic Response of Constrained Bubbles to Acoustic Excitation.This project will theoretically and experimentally characterize the linear and nonlinear dynamics of acoustically excited bubbles that are constrained within tubes and channels. The results of this work will be directly relevant to the use of ultrasound microbubble contrast agents in diagnostic imaging and new ultrasound-based therapies.
January 23, 2007
Diane Dalecki, associate professor of biomedical engineering, has been appointed the new director of the Rochester Center for Biomedical Ultrasound (RCBU) at the University of Rochester. Created in 1986, the RCBU provides a unique environment where researchers from many institutions can join together to investigate the use of very high frequency sound waves in medical diagnosis and therapy.
- Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound. Ann Biomed Eng. In press. (2014 Mar 14).
- Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A. 19, 2517-26. (2013 Nov 01).
- Controlling collagen fiber microstructure in three-dimensional hydrogels using ultrasound. J Acoust Soc Am. 134, 1491-502. (2013 Aug 01).