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Principal Investigator

David A. Dean, Ph.D. University of Rochester work Box 850 601 Elmwood Ave Rochester NY 14642 office: MRBX 3-11126 p 585-275-5948 f 585-756-7780 David_Dean@urmc.rochester.edu

Recent Publications

The following list was auto-generated 6 days ago.

• 1. Badding MA
  2. Lapek JD
  3. Friedman AE
  4. Dean DA
  (2013 Apr 01). Proteomic and functional analyses of protein-DNA complexes during gene transfer. Mol Ther. 21, 775-85.
• 1. Dean DA
  (2013 Mar 24). Cell-Specific Targeting Strategies for Electroporation-Mediated Gene Delivery in Cells and Animals. J Membr Biol. In press.
• 1. Badding MA
  2. Dean DA
  (2012 Sep 27). Highly acetylated tubulin permits enhanced interactions with and trafficking of plasmids along microtubules. Gene Ther. In press.
• 1. O'Reilly MA
  2. Yee M
  3. Buczynski BW
  4. Vitiello PF
  5. Keng PC
  6. Welle SL
  7. Finkelstein JN
  8. Dean DA
  9. Lawrence BP
  (2012 Aug 01). Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1. Am J Pathol. 181, 441-51.
• 1. Yao H
  2. Chung S
  3. Hwang JW
  4. Rajendrasozhan S
  5. Sundar IK
  6. Dean DA
  7. McBurney MW
  8. Guarente L
  9. Gu W
  10. Rönty M
  11. Kinnula VL
  12. Rahman I
  (2012 Jun 01). SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest. 122, 2032-45.
• 1. Badding MA
  2. Vaughan EE
  3. Dean DA
  (2012 Mar 01). Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer. Gene Ther. 19, 338-46.
• 1. Lin X
  2. Dean DA
  (2011 Jul 01). Gene therapy for ALI/ARDS. Crit Care Clin. 27, 705-18.
• 1. Eldib M
  2. Dean DA
  (2011 Feb 01). Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics. Biotechnol Bioeng. 108, 446-53.
• 1. Kaufman CD
  2. Geiger RC
  3. Dean DA
  (2010 Sep 01). Electroporation- and mechanical ventilation-mediated gene transfer to the lung. Gene Ther. 17, 1098-104.
• 1. Staversky RJ
  2. Vitiello PF
  3. Yee M
  4. Callahan LM
  5. Dean DA
  6. O'Reilly MA
  (2010 Sep 01). Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development. Am J Respir Cell Mol Biol. 43, 376-85.
• 1. Lam AP
  2. Dean DA
  (2010 Apr 01). Progress and prospects: nuclear import of nonviral vectors. Gene Ther. 17, 439-47.
• 1. Degiulio JV
  2. Kaufman CD
  3. Dean DA
  (2010 Apr 01). The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression. Gene Ther. 17, 541-9.
• 1. Wang Y
  2. Heilig KO
  3. Minto AW
  4. Chen S
  5. Xiang M
  6. Dean DA
  7. Geiger RC
  8. Chang A
  9. Pravtcheva DD
  10. Schlimme M
  11. Deb DK
  12. Wang Y
  13. Heilig CW
  (2010 Jan 01). Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF. Lab Invest. 90, 83-97.
• 1. Miller AM
  2. Munkonge FM
  3. Alton EW
  4. Dean DA
  (2009 Nov 01). Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import. Mol Ther. 17, 1897-903.
• 1. Yee M
  2. Chess PR
  3. McGrath-Morrow SA
  4. Wang Z
  5. Gelein R
  6. Zhou R
  7. Dean DA
  8. Notter RH
  9. O'Reilly MA
  (2009 Oct 01). Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. Am J Physiol Lung Cell Mol Physiol. 297, L641-9.
• 1. Aistrup GL
  2. Villuendas R
  3. Ng J
  4. Gilchrist A
  5. Lynch TW
  6. Gordon D
  7. Cokic I
  8. Mottl S
  9. Zhou R
  10. Dean DA
  11. Wasserstrom JA
  12. Goldberger JJ
  13. Kadish AH
  14. Arora R
  (2009 Aug 01). Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation. Cardiovasc Res. 83, 481-92.
• 1. Miller AM
  2. Dean DA
  (2009 Jul 02). Tissue-specific and transcription factor-mediated nuclear entry of DNA. Adv Drug Deliv Rev. 61, 603-13.
• 1. Geiger RC
  2. Kaufman CD
  3. Lam AP
  4. Budinger GR
  5. Dean DA
  (2009 Jan 01). Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load. Am J Respir Cell Mol Biol. 40, 76-82.
• 1. Vaughan EE
  2. Geiger RC
  3. Miller AM
  4. Loh-Marley PL
  5. Suzuki T
  6. Miyata N
  7. Dean DA
  (2008 Nov 01). Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency. Mol Ther. 16, 1841-7.
• 1. Miller AM
  2. Dean DA
  (2008 Aug 01). Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences. Gene Ther. 15, 1107-15.
• 1. Young JL
  2. Zimmer WE
  3. Dean DA
  (2008 Jul 01). Smooth muscle-specific gene delivery in the vasculature based on restriction of DNA nuclear import. Exp Biol Med (Maywood). 233, 840-8.
• 1. Lam AP
  2. Dean DA
  (2008 Jun 01). Cyclic stretch-induced nuclear localization of transcription factors results in increased nuclear targeting of plasmids in alveolar epithelial cells. J Gene Med. 10, 668-78.
• 1. Dean DA
  2. Ramanathan T
  3. Machado D
  4. Sundararajan R
  (2008 Mar 01). Electrical Impedance Spectroscopy Study of Biological Tissues. J Electrostat. 66, 165-177.
• 1. Zhou R
  2. Norton JE
  3. Dean DA
  (2008 Jan 01). Electroporation-mediated gene delivery to the lungs. Methods Mol Biol. 423, 233-47.
• 1. Gasiorowski JZ
  2. Dean DA
  (2007 Dec 01). Intranuclear trafficking of episomal DNA is transcription-dependent. Mol Ther. 15, 2132-9.
• 1. Mutlu GM
  2. Green D
  3. Bellmeyer A
  4. Baker CM
  5. Burgess Z
  6. Rajamannan N
  7. Christman JW
  8. Foiles N
  9. Kamp DW
  10. Ghio AJ
  11. Chandel NS
  12. Dean DA
  13. Sznajder JI
  14. Budinger GR
  (2007 Oct 01). Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest. 117, 2952-61.
• 1. Mutlu GM
  2. Machado-Aranda D
  3. Norton JE
  4. Bellmeyer A
  5. Urich D
  6. Zhou R
  7. Dean DA
  (2007 Sep 15). Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. Am J Respir Crit Care Med. 176, 582-90.
• 1. Zhou R
  2. Norton JE
  3. Zhang N
  4. Dean DA
  (2007 May 01). Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation. Gene Ther. 14, 775-80.
• 1. Bellmeyer A
  2. Martino JM
  3. Chandel NS
  4. Scott Budinger GR
  5. Dean DA
  6. Mutlu GM
  (2007 Mar 15). Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 175, 587-94.
• 1. Zhou R
  2. Dean DA
  (2007 Mar 01). Gene transfer of interleukin 10 to the murine cornea using electroporation. Exp Biol Med (Maywood). 232, 362-9.
• 1. Kopp K
  2. Gasiorowski JZ
  3. Chen D
  4. Gilmore R
  5. Norton JT
  6. Wang C
  7. Leary DJ
  8. Chan EK
  9. Dean DA
  10. Huang S
  (2007 Feb 01). Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol Biol Cell. 18, 394-403.
• 1. Vaughan EE
  2. DeGiulio JV
  3. Dean DA
  (2006 Dec 01). Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import. Curr Gene Ther. 6, 671-81.
• 1. Geiger RC
  2. Taylor W
  3. Glucksberg MR
  4. Dean DA
  (2006 Apr 01). Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer. Gene Ther. 13, 725-31.
• 1. Vaughan EE
  2. Dean DA
  (2006 Feb 01). Intracellular trafficking of plasmids during transfection is mediated by microtubules. Mol Ther. 13, 422-8.
• 1. Gasiorowski JZ
  2. Dean DA
  (2005 Sep 01). Postmitotic nuclear retention of episomal plasmids is altered by DNA labeling and detection methods. Mol Ther. 12, 460-7.
• 1. Dean DA
  (2005 Aug 01). Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals. Am J Physiol Cell Physiol. 289, C233-45.
• 1. Jones JC
  2. Lane K
  3. Hopkinson SB
  4. Lecuona E
  5. Geiger RC
  6. Dean DA
  7. Correa-Meyer E
  8. Gonzales M
  9. Campbell K
  10. Sznajder JI
  11. Budinger S
  (2005 Jun 15). Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. J Cell Sci. 118, 2557-66.
• 1. Dean DA
  2. Strong DD
  3. Zimmer WE
  (2005 Jun 01). Nuclear entry of nonviral vectors. Gene Ther. 12, 881-90.
• 1. Machado-Aranda D
  2. Adir Y
  3. Young JL
  4. Briva A
  5. Budinger GR
  6. Yeldandi AV
  7. Sznajder JI
  8. Dean DA
  (2005 Feb 01). Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance. Am J Respir Crit Care Med. 171, 204-11.
• 1. Wang L
  2. Dean DA
  3. Macdonald RC
  (2005 Jan 01). Effect of vinblastine on transfection: influence of cell types, cationic lipids and promoters. Curr Drug Deliv. 2, 93-6.
• 1. Zhou R
  2. Geiger RC
  3. Dean DA
  (2004 Nov 01). Intracellular trafficking of nucleic acids. Expert Opin Drug Deliv. 1, 127-40.
• 1. Dean DA
  (2003 Dec 01). Electroporation of the vasculature and the lung. DNA Cell Biol. 22, 797-806.
• 1. Nunamaker EA
  2. Zhang HY
  3. Shirasawa Y
  4. Benoit JN
  5. Dean DA
  (2003 Nov 01). Electroporation-mediated delivery of catalytic oligodeoxynucleotides for manipulation of vascular gene expression. Am J Physiol Heart Circ Physiol. 285, H2240-7.
• 1. Dean DA
  2. Machado-Aranda D
  3. Blair-Parks K
  4. Yeldandi AV
  5. Young JL
  (2003 Sep 01). Electroporation as a method for high-level nonviral gene transfer to the lung. Gene Ther. 10, 1608-15.
• 1. Young JL
  2. Benoit JN
  3. Dean DA
  (2003 Aug 01). Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature. Gene Ther. 10, 1465-70.
• 1. Gasiorowski JZ
  2. Dean DA
  (2003 Jun 16). Mechanisms of nuclear transport and interventions. Adv Drug Deliv Rev. 55, 703-16.
• 1. Taylor W
  2. Gokay KE
  3. Capaccio C
  4. Davis E
  5. Glucksberg M
  6. Dean DA
  (2003 Apr 01). The effects of cyclic stretch on gene transfer in alveolar epithelial cells. Mol Ther. 7, 542-9.
• 1. Budinger GR
  2. Tso M
  3. McClintock DS
  4. Dean DA
  5. Sznajder JI
  6. Chandel NS
  (2002 May 03). Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins. J Biol Chem. 277, 15654-60.
• 1. Filmore RA
  2. Dean DA
  3. Zimmer WE
  (2002 Jan 01). The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia. Gene Expr. 10, 201-11.
• 1. Young JL
  2. Dean DA
  (2002 Jan 01). Nonviral gene transfer strategies for the vasculature. Microcirculation. 9, 35-49.