Signal Transduction; Membrane Protein Structure, Yeast Molecular Biology
Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.
- Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochim Biophys Acta. 1838, 15-33. (2014 Jan 01).
- Structure of the integral membrane protein CAAX protease Ste24p. Science. 339, 1600-4. (2013 Mar 29).
- Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol. 20, 135-8. (2013 Feb 01).