Principal Investigator

Deborah Fowell, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9641 p 585-273-3680

Research Projects

  • Execution of CD4 Effector Function

    Execution of CD4 Effector Function

    The molecular control of CD4 differentiation into functionally distinct effector lineages has been extensively studied but the fate of the effector T cells once they leave the lymph node is less well understood. We are interested in how the inflammatory milieu at sites of infection and autoimmune attack may modify the effector function of CD4+ T cells. More info...

  • CD4 T Cell Motility in Inflamed Tissue

    CD4 T Cell Motility in Inflamed Tissue

    Cell migration is determined by the cell-intrinsic machinery for motility such as integrins, actin regulators and chemokine receptors and by the extrinsic composition of the extracellular matrix. The way in which effector CD4 T cells navigate through inflamed interstitial tissue at sites of infection is not well understood. More info...

  • Immune Regulation by Regulatory T Cells

    Immune Regulation by Regulatory T Cells

    Regulatory T cells (Tregs) play an important role in modulating immune response to self-antigens and infectious agents. Multiple regulatory mechanisms have been assigned to Tregs but how they modulate discrete immune functions has not been well defined. We are interested in determining how Tregs block cytokine production by CD4 T cells and how effector T cells may in turn modulate Treg function. More info...