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Principal Investigator

Deborah Fowell, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9641 p 585-273-3680 Deborah_Fowell@urmc.rochester.edu

Recent Publications

The following list was auto-generated 1 day ago.

• 1. Hyun YM
  2. Sumagin R
  3. Sarangi PP
  4. Lomakina E
  5. Overstreet MG
  6. Baker CM
  7. Fowell DJ
  8. Waugh RE
  9. Sarelius IH
  10. Kim M
  (2012 Jul 02). Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 209, 1349-62.
• 1. Huang YH
  2. Sojka DK
  3. Fowell DJ
  (2012 Feb 01). Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells. J Immunol. 188, 947-51.
• 1. Mock DJ
  2. Hollenbaugh JA
  3. Daddacha W
  4. Overstreet MG
  5. Lazarski CA
  6. Fowell DJ
  7. Kim B
  (2012 Jan 01). Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection. PLoS Pathog. 8, e1002635.
• 1. Sojka DK
  2. Fowell DJ
  (2011 Nov 08). Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10. Proc Natl Acad Sci U S A. 108, 18336-41.
• 1. Singleton KL
  2. Gosh M
  3. Dandekar RD
  4. Au-Yeung BB
  5. Ksionda O
  6. Tybulewicz VL
  7. Altman A
  8. Fowell DJ
  9. Wülfing C
  (2011 Oct 04). Itk controls the spatiotemporal organization of T cell activation. Sci Signal. 4, ra66.
• 1. Hughson A
  2. Bromberg I
  3. Johnson B
  4. Quataert S
  5. Jospe N
  6. Fowell DJ
  (2011 Aug 01). Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes. 60, 2125-33.
• 1. Morales-Tirado V
  2. Sojka DK
  3. Katzman SD
  4. Lazarski CA
  5. Finkelman FD
  6. Urban JF
  7. Fowell DJ
  (2010 Apr 29). Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 115, 3498-507.
• 1. Sahu N
  2. Morales JL
  3. Fowell D
  4. August A
  (2010 Jan 01). Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk. PLoS One. 5, e11348.
• 1. Sojka DK
  2. Lazarski CA
  3. Huang YH
  4. Bromberg I
  5. Hughson A
  6. Fowell DJ
  (2009 Dec 01). Regulation of immunity at tissue sites of inflammation. Immunol Res. 45, 239-50.
• 1. Sojka DK
  2. Hughson A
  3. Fowell DJ
  (2009 Jun 01). CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. Eur J Immunol. 39, 1544-51.
• 1. Fowell DJ
  (2009 Apr 01). Signals for the execution of Th2 effector function. Cytokine. 46, 1-6.
• 1. Lazarski CA
  2. Hughson A
  3. Sojka DK
  4. Fowell DJ
  (2008 Oct 17). Regulating Treg cells at sites of inflammation. Immunity. 29, 511; author reply 512.
• 1. Sojka DK
  2. Huang YH
  3. Fowell DJ
  (2008 May 01). Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology. 124, 13-22.
• 1. Katzman SD
  2. Fowell DJ
  (2008 Feb 01). Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site. J Clin Invest. 118, 801-11.
• 1. Zhao X
  2. Zheng B
  3. Huang Y
  4. Yang D
  5. Katzman S
  6. Chang C
  7. Fowell D
  8. Zeng WP
  (2007 Dec 15). Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. J Immunol. 179, 8297-304.
• 1. Au-Yeung BB
  2. Fowell DJ
  (2007 Jul 01). A key role for Itk in both IFN gamma and IL-4 production by NKT cells. J Immunol. 179, 111-9.
• 1. Sukiennicki TL
  2. Fowell DJ
  (2006 Nov 15). Distinct molecular program imposed on CD4+ T cell targets by CD4+CD25+ regulatory T cells. J Immunol. 177, 6952-61.
• 1. Kobie JJ
  2. Shah PR
  3. Yang L
  4. Rebhahn JA
  5. Fowell DJ
  6. Mosmann TR
  (2006 Nov 15). T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol. 177, 6780-6.
• 1. Au-Yeung BB
  2. Katzman SD
  3. Fowell DJ
  (2006 Apr 01). Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol. 176, 3895-9.
• 1. Sojka DK
  2. Hughson A
  3. Sukiennicki TL
  4. Fowell DJ
  (2005 Dec 01). Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity. J Immunol. 175, 7274-80.
• 1. Morales-Tirado V
  2. Johannson S
  3. Hanson E
  4. Howell A
  5. Zhang J
  6. Siminovitch KA
  7. Fowell DJ
  (2004 Jul 15). Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells. J Immunol. 173, 726-30.
• 1. Gurunathan S
  2. Stobie L
  3. Prussin C
  4. Sacks DL
  5. Glaichenhaus N
  6. Iwasaki A
  7. Fowell DJ
  8. Locksley RM
  9. Chang JT
  10. Wu CY
  11. Seder RA
  (2000 Jul 15). Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 165, 915-24.
• 1. Pippig SD
  2. Peña-Rossi C
  3. Long J
  4. Godfrey WR
  5. Fowell DJ
  6. Reiner SL
  7. Birkeland ML
  8. Locksley RM
  9. Barclay AN
  10. Killeen N
  (1999 Dec 15). Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 163, 6520-9.
• 1. Heath VL
  2. Hutchings P
  3. Fowell DJ
  4. Cooke A
  5. Mason DW
  (1999 Nov 01). Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes. Diabetes. 48, 2157-65.
• 1. Fowell DJ
  2. Shinkai K
  3. Liao XC
  4. Beebe AM
  5. Coffman RL
  6. Littman DR
  7. Locksley RM
  (1999 Oct 01). Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity. 11, 399-409.
• 1. Fowell DJ
  2. Locksley RM
  (1999 Jun 01). Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Bioessays. 21, 510-8.
• 1. Pingel S
  2. Launois P
  3. Fowell DJ
  4. Turck CW
  5. Southwood S
  6. Sette A
  7. Glaichenhaus N
  8. Louis JA
  9. Locksley RM
  (1999 Apr 05). Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. J Exp Med. 189, 1111-20.
• 1. Locksley RM
  2. Pingel S
  3. Lacy D
  4. Wakil AE
  5. Bix M
  6. Fowell DJ
  (1999 Mar 01). Susceptibility to infectious diseases: Leishmania as a paradigm. J Infect Dis. 179 Suppl 2, S305-8.
• 1. Wakil AE
  2. Wang ZE
  3. Ryan JC
  4. Fowell DJ
  5. Locksley RM
  (1998 Nov 02). Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med. 188, 1651-6.
• 1. Fowell DJ
  2. Bix M
  3. Shinkai K
  4. Lacy D
  5. Locksley RM
  (1998 Sep 01). Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. Eur Cytokine Netw. 9, 102-6.
• 1. Reiner SL
  2. Fowell DJ
  3. Moskowitz NH
  4. Swier K
  5. Brown DR
  6. Brown CR
  7. Turck CW
  8. Scott PA
  9. Killeen N
  10. Locksley RM
  (1998 Jan 15). Control of Leishmania major by a monoclonal alpha beta T cell repertoire. J Immunol. 160, 884-9.
• 1. Locksley RM
  2. Fowell DJ
  3. Shinkai K
  4. Wakil AE
  5. Lacy D
  6. Bix M
  (1998 Jan 01). Development of CD4+ effector T cells and susceptibility to infectious diseases. Adv Exp Med Biol. 452, 45-52.
• 1. Hagenbaugh A
  2. Sharma S
  3. Dubinett SM
  4. Wei SH
  5. Aranda R
  6. Cheroutre H
  7. Fowell DJ
  8. Binder S
  9. Tsao B
  10. Locksley RM
  11. Moore KW
  12. Kronenberg M
  (1997 Jun 16). Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 185, 2101-10.
• 1. Fowell DJ
  2. Magram J
  3. Turck CW
  4. Killeen N
  5. Locksley RM
  (1997 May 01). Impaired Th2 subset development in the absence of CD4. Immunity. 6, 559-69.
• 1. Fowell DJ
  2. Wakil AE
  3. Locksley RM
  (1996 Dec 16). Interleukin-12 in murine leishmaniasis--match, flame or fuel? Res Immunol. 146, 566-75.
• 1. Saoudi A
  2. Seddon B
  3. Fowell D
  4. Mason D
  (1996 Dec 01). The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med. 184, 2393-8.
• 1. Brown DR
  2. Fowell DJ
  3. Corry DB
  4. Wynn TA
  5. Moskowitz NH
  6. Cheever AW
  7. Locksley RM
  8. Reiner SL
  (1996 Oct 01). Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med. 184, 1295-304.
• 1. Ramírez F
  2. Fowell DJ
  3. Puklavec M
  4. Simmonds S
  5. Mason D
  (1996 Apr 01). Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol. 156, 2406-12.
• 1. Heath VL
  2. Saoudi A
  3. Seddon BP
  4. Moore NC
  5. Fowell DJ
  6. Mason DW
  (1996 Apr 01). The role of the thymus in the control of autoimmunity. J Autoimmun. 9, 241-6.
• 1. Saoudi A
  2. Seddon B
  3. Heath V
  4. Fowell D
  5. Mason D
  (1996 Feb 01). The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol Rev. 149, 195-216.
• 1. Fowell D
  2. Powrie F
  3. Saoudi A
  4. Seddon B
  5. Heath V
  6. Mason D
  (1995 Jan 01). The role of subsets of CD4+ T cells in autoimmunity. Ciba Found Symp. 195, 173-82; discussion 182-8.
• 1. Locksley RM
  2. Wakil AE
  3. Corry DB
  4. Pingel S
  5. Bix M
  6. Fowell DJ
  (1995 Jan 01). The development of effector T cell subsets in murine Leishmania major infection. Ciba Found Symp. 195, 110-7; discussion 117-22.
• 1. Cyster JG
  2. Fowell D
  3. Barclay AN
  (1994 Dec 01). Antigenic determinants encoded by alternatively spliced exons of CD45 are determined by the polypeptide but influenced by glycosylation. Int Immunol. 6, 1875-81.
• 1. Fowell D
  2. Mason D
  (1993 Mar 01). Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med. 177, 627-36.
• 1. Mason D
  2. Fowell D
  (1992 Dec 01). T-cell subsets in autoimmunity. Curr Opin Immunol. 4, 728-32.
• 1. Fowell D
  2. McKnight AJ
  3. Powrie F
  4. Dyke R
  5. Mason D
  (1991 Oct 01). Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity. Immunol Rev. 123, 37-64.
• 1. Powrie F
  2. Fowell D
  3. McKnight AJ
  4. Mason D
  (1991 Jan 01). Lineage relationships and functions of CD4+ T-cell subsets in the rat. Res Immunol. 142, 54-8.