Principal Investigator

Julie L. Fudge, M.D. University of Rochester work Box 603 601 Elmwood Ave Rochester NY 14642 office: MC 5-8503 p 585-273-2028

Research Projects

  • Characterizing Amygdala Networks in Anxious Adolescents

    Characterizing Amygdala Networks in Anxious Adolescents

    Anxiety disorders emerge in adolescence and are marked by dysfunction of interconnected limbic regions, including the amygdala, pre-frontal cortex, and striatum. The amygdala has consistently been shown to be hyperactive among patients with anxiety disorders, and has connections with the pre-frontal cortex and the striatum. Certain projections from the pre-frontal cortex are thought to inhibit the amygdala, which in turn projects to the striatum to create an appropriate behavioral response to a salient stimulus. More info...

  • Effects of Stress on Amygdala Development and Behavior in Adolescent Rats

    Effects of Stress on Amygdala Development and Behavior in Adolescent Rats

    Adolescence is a time of rapid social, emotional, and cognitive growth, and also a time when symptoms of mood and anxiety disorders emerge. The amygdala is a central structure involved in emotional processing and learning. Recent evidence indicates that the amygdala structure and function is influenced by stress and glucocorticoids, possibly contributing to the amygdala’s well-known dysregulation in mood and anxiety disorders. More info...

  • Neural Substrates of Plasticity in the Amygdala

    Neural Substrates of Plasticity in the Amygdala

    This project involves characterizing immature-appearing neurons in the amygdala. These cells may be of special interest in understanding structural and functional change of the amygdala that occur in human mood disorders. More info...