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Principal Investigator

Elizabeth Grayhack, Ph.D. University of Rochester work Box 712 Rochester NY p 585-275-2765 f 585-275-6007 Elizabeth_Grayhack@urmc.rochester.edu

Recent Publications

The following list was auto-generated 1 week ago.

• 1. Grant TD
  2. Luft JR
  3. Wolfley JR
  4. Snell ME
  5. Tsuruta H
  6. Corretore S
  7. Quartley E
  8. Phizicky EM
  9. Grayhack EJ
  10. Snell EH
  (2013 Apr 10). The Structure of Yeast Glutaminyl-tRNA Synthetase and Modeling of Its Interaction with tRNA. J Mol Biol. In press.
• 1. Dean KM
  2. Grayhack EJ
  (2012 Dec 01). RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay. RNA. 18, 2335-44.
• 1. Grant TD
  2. Snell EH
  3. Luft JR
  4. Quartley E
  5. Corretore S
  6. Wolfley JR
  7. Snell ME
  8. Hadd A
  9. Perona JJ
  10. Phizicky EM
  11. Grayhack EJ
  (2012 Apr 01). Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Nucleic Acids Res. 40, 3723-31.
• 1. Letzring DP
  2. Dean KM
  3. Grayhack EJ
  (2010 Dec 01). Control of translation efficiency in yeast by codon-anticodon interactions. RNA. 16, 2516-28.
• 1. Quartley E
  2. Alexandrov A
  3. Mikucki M
  4. Buckner FS
  5. Hol WG
  6. DeTitta GT
  7. Phizicky EM
  8. Grayhack EJ
  (2009 Sep 01). Heterologous expression of L. major proteins in S. cerevisiae: a test of solubility, purity, and gene recoding. J Struct Funct Genomics. 10, 233-47.
• 1. Chernyakov I
  2. Whipple JM
  3. Kotelawala L
  4. Grayhack EJ
  5. Phizicky EM
  (2008 May 15). Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1. Genes Dev. 22, 1369-80.
• 1. Chernyakov I
  2. Baker MA
  3. Grayhack EJ
  4. Phizicky EM
  (2008 Jan 01). Chapter 11. Identification and analysis of tRNAs that are degraded in Saccharomyces cerevisiae due to lack of modifications. Methods Enzymol. 449, 221-37.
• 1. Jackman JE
  2. Grayhack EJ
  3. Phizicky EM
  (2008 Jan 01). The use of Saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins. Methods Mol Biol. 488, 383-93.
• 1. Kotelawala L
  2. Grayhack EJ
  3. Phizicky EM
  (2008 Jan 01). Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. RNA. 14, 158-69.
• 1. Malkowski MG
  2. Quartley E
  3. Friedman AE
  4. Babulski J
  5. Kon Y
  6. Wolfley J
  7. Said M
  8. Luft JR
  9. Phizicky EM
  10. DeTitta GT
  11. Grayhack EJ
  (2007 Apr 17). Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Proc Natl Acad Sci U S A. 104, 6678-83.
• 1. Wilkinson ML
  2. Crary SM
  3. Jackman JE
  4. Grayhack EJ
  5. Phizicky EM
  (2007 Mar 01). The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. RNA. 13, 404-13.
• 1. White MA
  2. Clark KM
  3. Grayhack EJ
  4. Dumont ME
  (2007 Jan 19). Characteristics affecting expression and solubilization of yeast membrane proteins. J Mol Biol. 365, 621-36.
• 1. Jackman JE
  2. Kotelawala L
  3. Grayhack EJ
  4. Phizicky EM
  (2007 Jan 01). Identification and characterization of modification enzymes by biochemical analysis of the proteome. Methods Enzymol. 425, 139-52.
• 1. Phizicky EM
  2. Grayhack EJ
  (2006 Aug 16). Proteome-scale analysis of biochemical activity. Crit Rev Biochem Mol Biol. 41, 315-27.
• 1. Alexandrov A
  2. Chernyakov I
  3. Gu W
  4. Hiley SL
  5. Hughes TR
  6. Grayhack EJ
  7. Phizicky EM
  (2006 Jan 06). Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell. 21, 87-96.
• 1. Gelperin DM
  2. White MA
  3. Wilkinson ML
  4. Kon Y
  5. Kung LA
  6. Wise KJ
  7. Lopez-Hoyo N
  8. Jiang L
  9. Piccirillo S
  10. Yu H
  11. Gerstein M
  12. Dumont ME
  13. Phizicky EM
  14. Snyder M
  15. Grayhack EJ
  (2005 Dec 01). Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev. 19, 2816-26.
• 1. Gu W
  2. Hurto RL
  3. Hopper AK
  4. Grayhack EJ
  5. Phizicky EM
  (2005 Sep 01). Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C. Mol Cell Biol. 25, 8191-201.
• 1. Ma X
  2. Yang C
  3. Alexandrov A
  4. Grayhack EJ
  5. Behm-Ansmant I
  6. Yu YT
  (2005 Jul 06). Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J. 24, 2403-13.
• 1. Alexandrov A
  2. Grayhack EJ
  3. Phizicky EM
  (2005 May 01). tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. RNA. 11, 821-30.
• 1. Alexandrov A
  2. Vignali M
  3. LaCount DJ
  4. Quartley E
  5. de Vries C
  6. De Rosa D
  7. Babulski J
  8. Mitchell SF
  9. Schoenfeld LW
  10. Fields S
  11. Hol WG
  12. Dumont ME
  13. Phizicky EM
  14. Grayhack EJ
  (2004 Sep 01). A facile method for high-throughput co-expression of protein pairs. Mol Cell Proteomics. 3, 934-8.
• 1. Van Slyke C
  2. Grayhack EJ
  (2003 Aug 01). The essential transcription factor Reb1p interacts with the CLB2 UAS outside of the G2/M control region. Nucleic Acids Res. 31, 4597-607.
• 1. Phizicky EM
  2. Martzen MR
  3. McCraith SM
  4. Spinelli SL
  5. Xing F
  6. Shull NP
  7. Van Slyke C
  8. Montagne RK
  9. Torres FM
  10. Fields S
  11. Grayhack EJ
  (2002 Jan 01). Biochemical genomics approach to map activities to genes. Methods Enzymol. 350, 546-59.
• 1. Grayhack EJ
  2. Phizicky EM
  (2001 Feb 01). Genomic analysis of biochemical function. Curr Opin Chem Biol. 5, 34-9.
• 1. Martzen MR
  2. McCraith SM
  3. Spinelli SL
  4. Torres FM
  5. Fields S
  6. Grayhack EJ
  7. Phizicky EM
  (1999 Nov 05). A biochemical genomics approach for identifying genes by the activity of their products. Science. 286, 1153-5.
• 1. Kuo MH
  2. Nadeau ET
  3. Grayhack EJ
  (1997 Feb 01). Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations. Mol Cell Biol. 17, 819-32.
• 1. Grayhack EJ
  (1992 Aug 01). The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site. Mol Cell Biol. 12, 3573-82.
• 1. Yang XJ
  2. Hart CM
  3. Grayhack EJ
  4. Roberts JW
  (1987 May 01). Transcription antitermination by phage lambda gene Q protein requires a DNA segment spanning the RNA start site. Genes Dev. 1, 217-26.
• 1. Grayhack EJ
  2. Yang XJ
  3. Lau LF
  4. Roberts JW
  (1985 Aug 01). Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site. Cell. 42, 259-69.
• 1. Grayhack EJ
  2. Roberts JW
  (1983 Aug 10). Purification of the bacteriophage lambda late gene regulator encoded by gene Q. J Biol Chem. 258, 9192-6.