Auditory & Vestibular Efferent Systems
The long-term goal of my laboratory is to understand the role of cochlear outer hair cells in hearing and hearing loss both at the molecular and at the systems level. Specifically, we are interested in agents that block or enhance the action of receptors on outer hair cells of the cochlea, which enhance hearing and decrease hearing loss. To design and discover agents that block or enhance receptor action on cochlear outer hair cells, we are cloning neurotransmitter receptors expressed in the hair cells, and modulating expression of these receptors by viral-mediated gene transfer into the cochlea.
- Loss of α-calcitonin gene-related peptide (αCGRP) reduces the efficacy of the Vestibulo-ocular Reflex (VOR).J Neurosci. 34, 10453-8. (2014 Jul 30).
- Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits.J Acoust Soc Am. 135, 1941-9. (2014 Apr 01).
- Loss of prestin does not alter the development of auditory cortical dendritic spines.Neural Plast. 2011, 305621. (2011 Jan 01).