• Patients & Families
• Education
• Research
• Community

• Referring Physicians
• Find a Physician
• Departments & Centers
• About URMC

• Libraries
• Alumni
• Giving

• Overview
• Working in the Lab
• Projects
• Publications
• Software
• Personnel
• Honors & News
• Lab Activities
• Maquat Lab intranet

Principal Investigator

Lynne Maquat, Ph.D. University of Rochester work Rochester NY Lynne_Maquat@urmc.rochester.edu

Recent Publications

The following list was auto-generated 2 weeks ago.

• 1. Wang J
  2. Gong C
  3. Maquat LE
  (2013 Apr 01). Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev. 27, 793-804.
• 1. Gleghorn ML
  2. Gong C
  3. Kielkopf CL
  4. Maquat LE
  (2013 Apr 01). Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol. 20, 515-24.
• 1. Trcek T
  2. Sato H
  3. Singer RH
  4. Maquat LE
  (2013 Mar 01). Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev. 27, 541-51.
• 1. Kurosaki T
  2. Maquat LE
  (2013 Feb 26). Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A. 110, 3357-62.
• 1. Park E
  2. Gleghorn ML
  3. Maquat LE
  (2013 Jan 08). Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A. 110, 405-12.
• 1. Gong C
  2. Popp MW
  3. Maquat LE
  (2012 Oct 01). Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods. 58, 88-93.
• 1. Schoenberg DR
  2. Maquat LE
  (2012 Apr 01). Regulation of cytoplasmic mRNA decay. Nat Rev Genet. 13, 246-59.
• 1. Hwang J
  2. Maquat LE
  (2011 Aug 01). Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev. 21, 422-30.
• 1. Gong C
  2. Maquat LE
  (2011 Jun 15). "Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell Cycle. 10, 1882-3.
• 1. Ju S
  2. Tardiff DF
  3. Han H
  4. Divya K
  5. Zhong Q
  6. Maquat LE
  7. Bosco DA
  8. Hayward LJ
  9. Brown RH
  10. Lindquist S
  11. Ringe D
  12. Petsko GA
  (2011 Apr 01). A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol. 9, e1001052.
• 1. Gleghorn ML
  2. Maquat LE
  (2011 Mar 18). UPF1 learns to relax and unwind. Mol Cell. 41, 621-3.
• 1. Gong C
  2. Maquat LE
  (2011 Feb 10). lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature. 470, 284-8.
• 1. Hwang J
  2. Sato H
  3. Tang Y
  4. Matsuda D
  5. Maquat LE
  (2010 Aug 13). UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell. 39, 396-409.
• 1. Maquat LE
  2. Tarn WY
  3. Isken O
  (2010 Aug 06). The pioneer round of translation: features and functions. Cell. 142, 368-74.
• 1. Maquat LE
  2. Hwang J
  3. Sato H
  4. Tang Y
  (2010 Jan 01). CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol. 75, 127-34.
• 1. Maquat LE
  2. Gong C
  (2009 Dec 01). Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans. 37, 1287-92.
• 1. Sato H
  2. Maquat LE
  (2009 Nov 01). Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev. 23, 2537-50.
• 1. Schoenberg DR
  2. Maquat LE
  (2009 Sep 01). Re-capping the message. Trends Biochem Sci. 34, 435-42.
• 1. Isken O
  2. Maquat LE
  (2009 Jan 01). Telomeric RNAs as a novel player in telomeric integrity. F1000 Biol Rep. 1, 90.
• 1. Gong C
  2. Kim YK
  3. Woeller CF
  4. Tang Y
  5. Maquat LE
  (2009 Jan 01). SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev. 23, 54-66.
• 1. Isken O
  2. Maquat LE
  (2008 Sep 01). The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet. 9, 699-712.
• 1. Saltzman AL
  2. Kim YK
  3. Pan Q
  4. Fagnani MM
  5. Maquat LE
  6. Blencowe BJ
  (2008 Jul 01). Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol. 28, 4320-30.
• 1. Woeller CF
  2. Gaspari M
  3. Isken O
  4. Maquat LE
  (2008 May 01). NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep. 9, 446-51.
• 1. Isken O
  2. Kim YK
  3. Hosoda N
  4. Mayeur GL
  5. Hershey JW
  6. Maquat LE
  (2008 Apr 18). Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell. 133, 314-27.
• 1. Sato H
  2. Hosoda N
  3. Maquat LE
  (2008 Feb 01). Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell. 29, 255-62.
• 1. Matsuda D
  2. Sato H
  3. Maquat LE
  (2008 Jan 01). Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells. Methods Enzymol. 449, 177-201.
• 1. Maquat LE
  2. Kiledjian M
  (2008 Jan 01). RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface. Methods Enzymol. 449, xvii-xviii.
• 1. Maquat LE
  2. Arraiano CM
  (2008 Jan 01). RNA turnover in prokaryotes, archaea and organelles. Preface. Methods Enzymol. 447, xxiii-xxiv.
• 1. Maquat LE
  2. Kiledjian M
  (2008 Jan 01). RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface. Methods Enzymol. 448, xxi-xxii.
• 1. Matsuda D
  2. Hosoda N
  3. Kim YK
  4. Maquat LE
  (2007 Oct 01). Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol. 14, 974-9.
• 1. Isken O
  2. Maquat LE
  (2007 Aug 01). Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev. 21, 1833-56.
• 1. Kim YK
  2. Furic L
  3. Parisien M
  4. Major F
  5. DesGroseillers L
  6. Maquat LE
  (2007 Jun 06). Staufen1 regulates diverse classes of mammalian transcripts. EMBO J. 26, 2670-81.
• 1. Kuzmiak HA
  2. Maquat LE
  (2006 Jul 01). Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol Med. 12, 306-16.
• 1. Hosoda N
  2. Lejeune F
  3. Maquat LE
  (2006 Apr 01). Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol. 26, 3085-97.
• 1. Pan Q
  2. Saltzman AL
  3. Kim YK
  4. Misquitta C
  5. Shai O
  6. Maquat LE
  7. Frey BJ
  8. Blencowe BJ
  (2006 Jan 15). Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev. 20, 153-8.
• 1. Hosoda N
  2. Kim YK
  3. Lejeune F
  4. Maquat LE
  (2005 Oct 01). CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 12, 893-901.
• 1. Lejeune F
  2. Maquat LE
  (2005 Jun 01). Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol. 17, 309-15.
• 1. Maquat LE
  (2005 May 01). Nonsense-mediated mRNA decay in mammals. J Cell Sci. 118, 1773-6.
• 1. Gao Q
  2. Das B
  3. Sherman F
  4. Maquat LE
  (2005 Mar 22). Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A. 102, 4258-63.
• 1. Kim YK
  2. Furic L
  3. Desgroseillers L
  4. Maquat LE
  (2005 Jan 28). Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell. 120, 195-208.
• 1. Valencia-Sánchez MA
  2. Maquat LE
  (2004 Nov 01). An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol. 14, 594-7.
• 1. Lejeune F
  2. Ranganathan AC
  3. Maquat LE
  (2004 Oct 01). eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol. 11, 992-1000.
• 1. Brumbaugh KM
  2. Otterness DM
  3. Geisen C
  4. Oliveira V
  5. Brognard J
  6. Li X
  7. Lejeune F
  8. Tibbetts RS
  9. Maquat LE
  10. Abraham RT
  (2004 Jun 04). The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 14, 585-98.
• 1. Chiu SY
  2. Lejeune F
  3. Ranganathan AC
  4. Maquat LE
  (2004 Apr 01). The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev. 18, 745-54.
• 1. Maquat LE
  (2004 Feb 01). Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol. 5, 89-99.
• 1. Lejeune F
  2. Maquat LE
  (2004 Jan 01). Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells. Methods Mol Biol. 257, 115-24.
• 1. Lejeune F
  2. Li X
  3. Maquat LE
  (2003 Sep 01). Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell. 12, 675-87.
• 1. Arraiano CM
  2. Maquat LE
  (2003 Jul 01). Post-transcriptional control of gene expression: effectors of mRNA decay. Mol Microbiol. 49, 267-76.
• 1. Chiu SY
  2. Serin G
  3. Ohara O
  4. Maquat LE
  (2003 Jan 01). Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA. 9, 77-87.
• 1. Maquat LE
  2. Serin G
  (2001 Jan 01). Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins. Cold Spring Harb Symp Quant Biol. 66, 313-20.