Nanomembrane Research Group
The Nanomembrane Research Group (NRG) includes students, engineers, scientists, faculty and entrepreneurs at UR, a local nanomembrane manufacturer SiMPore Inc., and the Rochester Institute of Technology (RIT) and a growing network of academic and industry collaborators from around the world. Together, we have grown a serendipitous material discovery into a growing Rochester-based enterprise.
We introduced the first practical ultrathin freestanding nanoporopus membranes at the University of Rochester in 2007. Today, we manufacture and apply a variety of nanoporous and microporous membranes with the common characteristics that they are ultrathin (15 nm - 400 nm) and made with silicon-based manufacturing. Because these 'nanomembranes' are orders-of-magnitude thinner than conventional membranes, they are orders-of-magnitude more permeable to both diffusing molecules and pressurized flows. Molecular scale thickness also enhances the resolution of separations when the membranes are used as sieves. The silicon platform enables the ready assembly of membranes into devices using easily customized, but also highly scalable, layer-by-layer assembly. The unique properties of silicon nanomembranes have sparked paradigm-shifting research programs in:
- Biological tissue models
- Small format hemodialysis
- Biosensors
- Electrokinetic devices
In addition to these applications, our team focuses on the basic science of ultrathin membranes including studies of transport and mechanics.
James L. McGrath
Principal Investigator
- Pericytes repair engineered defects in the basement membrane to restore barrier integrity in an in vitro model of the blood-brain barrier.; Materials today. Bio; Vol 35, pp. 102361. 2025 Sep 26.
- Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB-on-a-Chip Model of Systemic Inflammation Leading to Astrogliosis.; Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 Aug 27.
- Pericytes Repair Engineered Defects in the Basement Membrane to Restore Barrier Integrity in an in vitro Model of the Blood-Brain Barrier.; bioRxiv : the preprint server for biology. 2025 Jun 26.
- Risk Analysis of Unplanned Extubation and Inadvertent Endobronchial Intubation During Pediatric Cleft Palate and Lip Repair.; Paediatric anaesthesia. 2025 May 03.
News
Affiliations
- Biomedical Engineering
- Del Monte Institute for Neuroscience
- Environmental Health Sciences Center
- James P. Wilmot Cancer Center
- NIH T32 Training Grant in Immunology
- Pulmonary T32 Training Grant
- Biomedical Engineering Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Neuroscience Ph.D. Program
February 23, 2021
Rochester to advance research in biological imaging through new grant
September 29, 2020
Awad, McGrath and Miller receive a $4M NCATS/NIAMS Clinical Trials on a Chip grant to study tendon inflammation and fibrosis
April 21, 2020
Rochester researchers pursue quick ways to detect COVID-19—and better understand it
January 9, 2020
Detecting microplastics first step in assessing environmental harm
Contact Us
McGrath Lab
306 Goergen Hall
Rochester, NY 14620
(585) 273-4746
