IND 409 - Cell Biology
Fall Semester, 3 Cr.
Course Description: This course is designed primarily for graduate students. One-hour lectures include discussion of specific modern topics including: membrane structure and transport; intracellular compartments and protein sorting; cytoskeleton; signal transduction and cell-cell communication; cell cycle and its breakdown during cancer; and apoptosis. In addition to the lectures, workshops are held weekly to emphasize particular points with examples from the literature.
PTH 507 - Cancer Biology
Spring Semester, 3 Cr.
Course Description: The goal of this course is to provide a solid background and current understanding of cancer biology and cancer-related research. The lectures will cover key topics in cancer biology, including intrinsic regulatory mechanisms of cancer cell proliferation, the impact of microenvironment on tumor growth and metastasis, and the diagnosis and prognosis of cancer. Leading scientists in the cancer research field will deliver lectures on each topic and lead in-depth discussions centered on groundbreaking findings. As an advanced-level course, we will emphasize original experiments, critical thinking and reading of the primary literature rather than abstract facts and memorization. Active participation and in-class discussions among students are expected. more info
GEN 508 - Systems Biology
Spring Semester, 3 Cr.
Course Description: This is a graduate level course aimed at providing students with the up-to-date scientific information and background knowledge behind the biomedical research into functional genomics and molecular mechanisms of development and of disease pathogenesis. The lectures are in modular format with homework for each module. Six modules are currently included, each by an instructor(s) most familiar with the topics. The modules include:
- Overview of mammalian development and genomics
- Hematopoiesis and blood cell diseases
- CNS development, stem cells and systems biology
- Genomics of cardiovascular development and diseases
- Chromatin biology and epigenomics
- Genomic and systems biology approaches to cancer
- Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery. Oncogene. 32, 3809-18. (2013 Aug 15).
- On the underlying assumptions of threshold Boolean networks as a model for genetic regulatory network behavior. Front Genet. 4, 263. (2013 Jan 01).
- Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. Cell Stem Cell. 11, 359-72. (2012 Sep 07).