M. Kerry
O'Banion, M.D., Ph.D.
University of Rochester
work
Box 603
601 Elmwood Ave
Rochester
NY
14642
office: MC 5-8527A
p
585-275-5185
Kerry_obanion@urmc.rochester.edu
John
A.
Olschowka, Ph.D.
University of Rochester
work
Box 603
601 Elmwood Ave
Rochester
NY
14642
office: MC 5-6312
p
585-275-8238
john_olschowka@urmc.rochester.edu
O'Banion Lab
University of Rochester
work
MC 5-8527
601 Elmwood Ave
Rochester
NY
14642
p
585-275-5185
Olschowka Lab
University of Rochester
work
MC 5-6312
601 Elmwood Ave
Rochester
NY
14642
p
585-275-8238
CNS Neuroinflammation Research
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury. We are currently working on the following projects:
- Local CNS and Systemic Inflammatory Effects Following Space Radiation
- Low Dose Radiation Effects on Hippocampal Neurogenesis
- Mitigation of Brain Inflammation and Cognitive Impairment after Radiation Injury
- Neuroinflammation Following Therapeutic Radiation
- Role of Interleukin-1 in Alzheimer’s Disease Neuropathogenesis
- Role of Neuroinflammation in Methamphetamine Induced Neurotoxicity
Latest News
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Jacqueline Williams, Major Lab Collaborator, Appointed to Prestigious Leadership Positions
November 3
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Jacqueline Williams, Major Lab Collaborator, Awarded $15M to Expand Bioterrorism Research
August 11
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Jacqueline Williams, Major Lab Collaborator, Chairs National Space Biomedical Research Institute Science Committee
January 27
Recent Publications
- (2012 Feb 01). Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running. Brain Behav Immun. 26, 292-300.
- (2012 Jan 18). Neuroinflammation and Cognitive Dysfunction in Chronic Disease and Aging. J Neuroimmune Pharmacol. In press.
- (2011 Dec 16). Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer's Disease without Inducing Overt Neurodegeneration. J Neuroimmune Pharmacol. In press.





