CNS Neuroinflammation Research
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury.
Current Research Projects
- Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling. Oncogene. 33, 225-35. (2014 Jan 09).
- Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction. Radiat Res. 180, 398-406. (2013 Oct 01).
- It may take more than a shot: alternatives to immunotherapy for Alzheimer's disease. Biol Psychiatry. 74, 316-7. (2013 Sep 01).