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O Labs
University of Rochester
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Rochester
NY
Overview
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury. In particular, we have active projects in Alzheimer's disease (AD), methamphetamine neurotoxicity, and in normal CNS radiation injury.
Latest News
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Dr. Kerry O'Banion featured in NASA Fall Newsletter
October 1
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Dr. Kerry O'Banion invited to speak and Co-Chair the NIDA-sponsored session - 40th Annual Meeting of the American Society of Neurochemistry
March 7
Recent Publications
- (2009 Nov 16). Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory. Neuroscience. 164, 1484-95.
- (2009 Nov 09). Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun. In press.
- (2009 Jun 22). Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol. 40, 15-32.
