CNS Neuroinflammation Research
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury.
Current Research Projects
- Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease. Neurobiol Dis. 69, 124-33. (2014 Sep 01).
- Does peripheral inflammation contribute to Alzheimer disease? Evidence from animal models. Neurology. In press. (2014 Jul 02).
- Central nervous system effects of whole-body proton irradiation. Radiat Res. 182, 18-34. (2014 Jul 01).