Honors & News
February 11, 2013
Congratulations to NGP Graduate Student, Simantini Ghosh on winning a travel award to present her work at the 11th International Conference on Alzheimer's & Parkinson's Disease in Florence, Italy on March 6-10, 2013. Simi works in Dr. Kerry O'Banion's lab, studying the effects of sustained Interleukin 1 beta overexpression on Alzheimer's disease pathology in transgenic mice.
January 3, 2013
As if space travel was not already filled with enough dangers, a new study out today in the journal PLOS ONE shows that cosmic radiation – which would bombard astronauts on deep space missions to places like Mars – could accelerate the onset of Alzheimer’s disease.
Galactic cosmic radiation poses a significant threat to future astronauts,said M. Kerry O’Banion, M.D., Ph.D., a professor in the University of Rochester Medical Center (URMC) Department of Neurobiology & Anatomy and the senior author of the study.
The possibility that radiation exposure in space may give rise to health problems such as cancer has long been recognized. However, this study shows for the first time that exposure to radiation levels equivalent to a mission to Mars could produce cognitive problems and speed up changes in the brain that are associated with Alzheimer’s disease.
November 3, 2011
Jacqueline P. Williams, Ph.D., a University of Rochester faculty member and internationally recognized expert in radiation biology, has been named to leadership positions at three of the leading radiation oncology and research organizations in the world.
The American Society for Radiation Oncology (ASTRO) named Williams chair of its Scientific Research Council at the Society's 53rd annual meeting, held in Miami Beach, Fla. Williams was also recognized as one of 21 distinguished members that received ASTRO's Fellow designation at a ceremony during the meeting.
August 11, 2010
The University of Rochester Medical Center has received $15 million in federal bioterrorism funding that allows investigators to build on several discoveries made during the past five years to improve the ability to treat radiation injuries, especially from an act of terrorism.
URMC was awarded an initial grant of $21 million in 2005 to become part of a national research network, Centers for Medical Countermeasures Against Radiation. The centers were charged with researching how best to respond to a dirty bomb or other radiological or nuclear attack.
A second, $15 million, five-year award, received this month from the National Institutes of Health/National Institute of Allergy and Infectious Disease, will allow URMC researchers to focus on testing known drugs and experimental agents and their ability to ward off systemic radiation injury that affects the lungs, brain, skin and bone marrow.
January 27, 2010
Jacqueline Williams, Major Lab Collaborator, Chairs National Space Biomedical Research Institute Science Committee
Jacqueline Williams, Ph.D., was named chair of the National Space Biomedical Research Institute's Scientific Advisory Committee for its Center of Acute Radiation Research. Williams is grant director and core leader of the Center for Biophysical Assessment and Risk Management Following Irradiation at the University of Rochester Medical Center.
NSBRI is a NASA-funded consortium of institutions studying the health risks related to long-duration spaceflight and developing countermeasures to mitigate the risks. The CARR, which is headed at the University of Pennsylvania School of Medicine, is responsible for studying the acute effects of exposure to space radiation during exploration missions. The Scientific Advisory Committee provides advice on the Center's productivity and effectiveness.
October 1, 2009
The son of two educators, Kerry O'Banion has always adopted a broad view in his scientific pursuits. As an undergraduate at the University of Illinois in Urbana-Champaign, he investigated pair bonding behavior in common prairie voles, but chose Microbiology for his PhD work because of the promise of immersing himself in molecular biology. Indeed, at the same time he was learning about human pathophysiology and how to do a proper neurological examination as an MD-PhD trainee in the nascent Medical Scholars Program, also at the University of Illinois in Urbana-Champaign, Kerry entertained working with Carl Woese, who had established the existence of a new kingdom of organisms (Archaea) by sequencing rRNA. Ultimately Kerry carried out his thesis work with Manfred Reichmann in Microbiology and John Sundberg in the Department of Veterinary Pathobiology to characterize and clone novel animal papillomaviruses. All together, he cloned viruses from six animal species and witnessed at national and international conferences the recognition that oncogenic human papillomaviruses caused cervical and other epithelial cancers.
March 7, 2009
Dr. Kerry O'Banion Presents & Co-Chairs the NIDA-sponsored session: 40th Annual Meeting of the American Society of Neurochemistry
Dr. Roger Sorensen, DBNBR, and Dr. Diane Lawrence, ARP, organized a colloquium titled: "Neurotoxicity or Neuroprotection: The Two Sides of Drug Abuse Action" that was held on March 7, 2009 in conjunction with the 40th Annual Meeting of the American Society for Neurochemistry (ASN) , Charleston, SC. The purpose of this colloquium was to disseminate current research findings on the biological mechanisms underlying neurotoxicity or neuroprotection produced by drugs of abuse, including the role of glia in these processes. The presenters were: M. Kerry O'Banion (University of Rochester Medical Center); Katherine Conant (Johns Hopkins University Medical Center); Jean-Christopher Rochet (Purdue University); and Stanley Thayer (University of Minnesota Medical School).
- Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies. Am J Pathol. 182, 2285-97. (2013 Jun 01).
- Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways. Clin Cancer Res. In press. (2013 May 28).
- Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory. J Neurochem. 125, 430-45. (2013 May 01).