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Principal Investigator

Peter Shrager, Ph.D. University of Rochester work Box 603 601 Elmwood Ave Rochester NY 14642 office: MC 4-5428 p 585-275-4748 peter_shrager@urmc.rochester.edu

Recent Publications

The following list was auto-generated 1 week ago.

• 1. Einheber S
  2. Meng X
  3. Rubin M
  4. Lam I
  5. Mohandas N
  6. An X
  7. Shrager P
  8. Kissil J
  9. Maurel P
  10. Salzer JL
  (2013 Feb 01). The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons. Glia. 61, 240-53.
• 1. Winters JJ
  2. Ferguson CJ
  3. Lenk GM
  4. Giger-Mateeva VI
  5. Shrager P
  6. Meisler MH
  7. Giger RJ
  (2011 Nov 30). Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4. J Neurosci. 31, 17736-51.
• 1. Raiker SJ
  2. Lee H
  3. Baldwin KT
  4. Duan Y
  5. Shrager P
  6. Giger RJ
  (2010 Sep 15). Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 30, 12432-45.
• 1. Feinberg K
  2. Eshed-Eisenbach Y
  3. Frechter S
  4. Amor V
  5. Salomon D
  6. Sabanay H
  7. Dupree JL
  8. Grumet M
  9. Brophy PJ
  10. Shrager P
  11. Peles E
  (2010 Feb 25). A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron. 65, 490-502.
• 1. Lee H
  2. Raiker SJ
  3. Venkatesh K
  4. Geary R
  5. Robak LA
  6. Zhang Y
  7. Yeh HH
  8. Shrager P
  9. Giger RJ
  (2008 Mar 12). Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci. 28, 2753-65.
• 1. Hedstrom KL
  2. Xu X
  3. Ogawa Y
  4. Frischknecht R
  5. Seidenbecher CI
  6. Shrager P
  7. Rasband MN
  (2007 Aug 27). Neurofascin assembles a specialized extracellular matrix at the axon initial segment. J Cell Biol. 178, 875-86.
• 1. Schafer DP
  2. Custer AW
  3. Shrager P
  4. Rasband MN
  (2006 May 01). Early events in node of Ranvier formation during myelination and remyelination in the PNS. Neuron Glia Biol. 2, 69-79.
• 1. Taveggia C
  2. Zanazzi G
  3. Petrylak A
  4. Yano H
  5. Rosenbluth J
  6. Einheber S
  7. Xu X
  8. Esper RM
  9. Loeb JA
  10. Shrager P
  11. Chao MV
  12. Falls DL
  13. Role L
  14. Salzer JL
  (2005 Sep 01). Neuregulin-1 type III determines the ensheathment fate of axons. Neuron. 47, 681-94.
• 1. Xu X
  2. Shrager P
  (2005 Feb 15). Dependence of axon initial segment formation on Na+ channel expression. J Neurosci Res. 79, 428-41.
• 1. Chen C
  2. Westenbroek RE
  3. Xu X
  4. Edwards CA
  5. Sorenson DR
  6. Chen Y
  7. McEwen DP
  8. O'Malley HA
  9. Bharucha V
  10. Meadows LS
  11. Knudsen GA
  12. Vilaythong A
  13. Noebels JL
  14. Saunders TL
  15. Scheuer T
  16. Shrager P
  17. Catterall WA
  18. Isom LL
  (2004 Apr 21). Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 24, 4030-42.
• 1. Custer AW
  2. Kazarinova-Noyes K
  3. Sakurai T
  4. Xu X
  5. Simon W
  6. Grumet M
  7. Shrager P
  (2003 Nov 05). The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. J Neurosci. 23, 10032-9.
• 1. Poliak S
  2. Salomon D
  3. Elhanany H
  4. Sabanay H
  5. Kiernan B
  6. Pevny L
  7. Stewart CL
  8. Xu X
  9. Chiu SY
  10. Shrager P
  11. Furley AJ
  12. Peles E
  (2003 Sep 15). Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol. 162, 1149-60.
• 1. Chen C
  2. Bharucha V
  3. Chen Y
  4. Westenbroek RE
  5. Brown A
  6. Malhotra JD
  7. Jones D
  8. Avery C
  9. Gillespie PJ
  10. Kazen-Gillespie KA
  11. Kazarinova-Noyes K
  12. Shrager P
  13. Saunders TL
  14. Macdonald RL
  15. Ransom BR
  16. Scheuer T
  17. Catterall WA
  18. Isom LL
  (2002 Dec 24). Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A. 99, 17072-7.
• 1. Kazarinova-Noyes K
  2. Shrager P
  (2002 Nov 13). Molecular constituents of the node of Ranvier. Mol Neurobiol. 26, 167-82.
• 1. Kazarinova-Noyes K
  2. Malhotra JD
  3. McEwen DP
  4. Mattei LN
  5. Berglund EO
  6. Ranscht B
  7. Levinson SR
  8. Schachner M
  9. Shrager P
  10. Isom LL
  11. Xiao ZC
  (2001 Oct 01). Contactin associates with Na+ channels and increases their functional expression. J Neurosci. 21, 7517-25.
• 1. Harroch S
  2. Palmeri M
  3. Rosenbluth J
  4. Custer A
  5. Okigaki M
  6. Shrager P
  7. Blum M
  8. Buxbaum JD
  9. Schlessinger J
  (2000 Oct 01). No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta. Mol Cell Biol. 20, 7706-15.
• 1. Rasband MN
  2. Trimmer JS
  3. Peles E
  4. Levinson SR
  5. Shrager P
  (2000 Jul 21). K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol. 28, 319-31.
• 1. Rasband MN
  2. Shrager P
  (2000 May 15). Ion channel sequestration in central nervous system axons. J Physiol. 525 Pt 1, 63-73.
• 1. Poliak S
  2. Gollan L
  3. Martinez R
  4. Custer A
  5. Einheber S
  6. Salzer JL
  7. Trimmer JS
  8. Shrager P
  9. Peles E
  (1999 Dec 01). Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron. 24, 1037-47.
• 1. Rasband MN
  2. Peles E
  3. Trimmer JS
  4. Levinson SR
  5. Lux SE
  6. Shrager P
  (1999 Sep 01). Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci. 19, 7516-28.
• 1. Weber P
  2. Bartsch U
  3. Rasband MN
  4. Czaniera R
  5. Lang Y
  6. Bluethmann H
  7. Margolis RU
  8. Levinson SR
  9. Shrager P
  10. Montag D
  11. Schachner M
  (1999 Jun 01). Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci. 19, 4245-62.
• 1. Vabnick I
  2. Trimmer JS
  3. Schwarz TL
  4. Levinson SR
  5. Risal D
  6. Shrager P
  (1999 Jan 15). Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J Neurosci. 19, 747-58.
• 1. Vabnick I
  2. Shrager P
  (1998 Oct 01). Ion channel redistribution and function during development of the myelinated axon. J Neurobiol. 37, 80-96.
• 1. Novakovic SD
  2. Levinson SR
  3. Schachner M
  4. Shrager P
  (1998 Aug 01). Disruption and reorganization of sodium channels in experimental allergic neuritis. Muscle Nerve. 21, 1019-32.
• 1. Shrager P
  2. Custer AW
  3. Kazarinova K
  4. Rasband MN
  5. Mattson D
  (1998 Feb 01). Nerve conduction block by nitric oxide that is mediated by the axonal environment. J Neurophysiol. 79, 529-36.
• 1. Rasband MN
  2. Trimmer JS
  3. Schwarz TL
  4. Levinson SR
  5. Ellisman MH
  6. Schachner M
  7. Shrager P
  (1998 Jan 01). Potassium channel distribution, clustering, and function in remyelinating rat axons. J Neurosci. 18, 36-47.
• 1. Vabnick I
  2. Messing A
  3. Chiu SY
  4. Levinson SR
  5. Schachner M
  6. Roder J
  7. Li C
  8. Novakovic S
  9. Shrager P
  (1997 Oct 15). Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice. J Neurosci Res. 50, 321-36.
• 1. Vabnick I
  2. Novaković SD
  3. Levinson SR
  4. Schachner M
  5. Shrager P
  (1996 Aug 15). The clustering of axonal sodium channels during development of the peripheral nervous system. J Neurosci. 16, 4914-22.
• 1. England JD
  2. Levinson SR
  3. Shrager P
  (1996 Aug 01). Immunocytochemical investigations of sodium channels along nodal and internodal portions of demyelinated axons. Microsc Res Tech. 34, 445-51.
• 1. Novakovic SD
  2. Deerinck TJ
  3. Levinson SR
  4. Shrager P
  5. Ellisman MH
  (1996 Jun 01). Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells. J Neurocytol. 25, 403-12.
• 1. Tzoumaka EE
  2. Novaković SD
  3. Levinson SR
  4. Shrager P
  (1995 Oct 01). Na+ channel aggregation in remyelinating mouse sciatic axons following transection. Glia. 15, 188-94.
• 1. Shrager P
  2. Novakovic SD
  (1995 Aug 28). Control of myelination, axonal growth, and synapse formation in spinal cord explants by ion channels and electrical activity. Brain Res Dev Brain Res. 88, 68-78.
• 1. Dugandzija-Novaković S
  2. Koszowski AG
  3. Levinson SR
  4. Shrager P
  (1995 Jan 01). Clustering of Na+ channels and node of Ranvier formation in remyelinating axons. J Neurosci. 15, 492-503.
• 1. Dugandzija-Novaković S
  2. Shrager P
  (1995 Jan 01). Survival, development, and electrical activity of central nervous system myelinated axons exposed to tumor necrosis factor in vitro. J Neurosci Res. 40, 117-26.
• 1. Wu JV
  2. Shrager P
  (1994 Aug 15). Resolving three types of chloride channels in demyelinated Xenopus axons. J Neurosci Res. 38, 613-20.
• 1. Wu JV
  2. Rubinstein CT
  3. Shrager P
  (1993 Dec 01). Single channel characterization of multiple types of potassium channels in demyelinated Xenopus axons. J Neurosci. 13, 5153-63.
• 1. Shrager P
  (1993 Aug 13). Axonal coding of action potentials in demyelinated nerve fibers. Brain Res. 619, 278-90.
• 1. Shen L
  2. Shrager P
  3. Girsch SJ
  4. Donaldson PJ
  5. Peracchia C
  (1991 Oct 01). Channel reconstitution in liposomes and planar bilayers with HPLC-purified MIP26 of bovine lens. J Membr Biol. 124, 21-32.
• 1. Hines M
  2. Shrager P
  (1991 Jan 01). A computational test of the requirements for conduction in demyelinated axons. Restor Neurol Neurosci. 3, 81-93.
• 1. Rubinstein CT
  2. Shrager P
  (1990 Aug 06). Remyelination of nerve fibers in the transected frog sciatic nerve. Brain Res. 524, 303-12.
• 1. Shrager P
  2. Rubinstein CT
  (1990 May 01). Optical measurement of conduction in single demyelinated axons. J Gen Physiol. 95, 867-89.
• 1. Shrager P
  (1989 Mar 27). Sodium channels in single demyelinated mammalian axons. Brain Res. 483, 149-54.
• 1. Shrager P
  (1988 Oct 01). Ionic channels and signal conduction in single remyelinating frog nerve fibres. J Physiol. 404, 695-712.
• 1. Shrager P
  (1987 Nov 01). The distribution of sodium and potassium channels in single demyelinated axons of the frog. J Physiol. 392, 587-602.
• 1. Shrager P
  2. Chiu SY
  3. Ritchie JM
  4. Zecevic D
  5. Cohen LB
  (1987 Feb 01). Optical recording of action potential propagation in demyelinated frog nerve. Biophys J. 51, 351-5.
• 1. Chiu SY
  2. Shrager P
  3. Ritchie JM
  (1985 Dec 16). Loose patch clamp recording of ionic currents in demyelinated frog nerve fibers. Brain Res. 359, 338-42.
• 1. Shrager P
  2. Chiu SY
  3. Ritchie JM
  (1985 Feb 01). Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells. Proc Natl Acad Sci U S A. 82, 948-52.
• 1. Shrager P
  2. Starkus JC
  3. Lo MV
  4. Peracchia C
  (1983 Aug 01). The periaxonal space of crayfish giant axons. J Gen Physiol. 82, 221-44.