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Principal Investigator

David Topham, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9631 p 585-273-1403 f 585-273-2452 David_Topham@urmc.rochester.edu

Recent Publications

The following list was auto-generated 3 days ago.

• 1. Sharma S
  2. Sundararajan A
  3. Suryawanshi A
  4. Kumar N
  5. Veiga-Parga T
  6. Kuchroo VK
  7. Thomas PG
  8. Sangster MY
  9. Rouse BT
  (2011 Nov 22). T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A. 108, 19001-6.
• 1. Santiago FW
  2. Fitzgerald T
  3. Treanor JJ
  4. Topham DJ
  (2011 Nov 08). Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus. Vaccine. 29, 8888-97.
• 1. Wu H
  2. Kumar A
  3. Miao H
  4. Holden-Wiltse J
  5. Mosmann TR
  6. Livingstone AM
  7. Belz GT
  8. Perelson AS
  9. Zand MS
  10. Topham DJ
  (2011 Nov 01). Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors. J Immunol. 187, 4474-82.
• 1. Su X
  2. Sangster MY
  3. D'Souza DH
  (2011 Nov 01). Time-dependent effects of pomegranate juice and pomegranate polyphenols on foodborne viral reduction. Foodborne Pathog Dis. 8, 1177-83.
• 1. de Graaf N
  2. van Helden MJ
  3. Textoris-Taube K
  4. Chiba T
  5. Topham DJ
  6. Kloetzel PM
  7. Zaiss DM
  8. Sijts AJ
  (2011 Apr 01). PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. Eur J Immunol. 41, 926-35.
• 1. Scheible K
  2. Zhang G
  3. Baer J
  4. Azadniv M
  5. Lambert K
  6. Pryhuber G
  7. Treanor JJ
  8. Topham DJ
  (2011 Mar 03). CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses. Vaccine. 29, 2159-68.
• 1. Mace CR
  2. Topham DJ
  3. Mosmann TR
  4. Quataert SA
  5. Treanor JJ
  6. Miller BL
  (2011 Jan 15). Label-free, arrayed sensing of immune response to influenza antigens. Talanta. 83, 1000-5.
• 1. Chapman TJ
  2. Lambert K
  3. Topham DJ
  (2011 Jan 01). Rapid reactivation of extralymphoid CD4 T cells during secondary infection. PLoS One. 6, e20493.
• 1. Azadniv M
  2. Bowers WJ
  3. Topham DJ
  4. Crispe IN
  (2011 Jan 01). CD4+ T cell effects on CD8+ T cell location defined using bioluminescence. PLoS One. 6, e16222.
• 1. Guo H
  2. Santiago F
  3. Lambert K
  4. Takimoto T
  5. Topham DJ
  (2011 Jan 01). T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. J Virol. 85, 448-55.
• 1. Su X
  2. Sangster MY
  3. D'Souza DH
  (2010 Dec 01). In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates. Foodborne Pathog Dis. 7, 1473-9.
• 1. Sundararajan A
  2. Ganapathy R
  3. Huan L
  4. Dunlap JR
  5. Webby RJ
  6. Kotwal GJ
  7. Sangster MY
  (2010 Oct 01). Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral Res. 88, 1-9.
• 1. Guo H
  2. Topham DJ
  (2010 Aug 01). Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection. J Virol. 84, 7750-9.
• 1. Miao H
  2. Hollenbaugh JA
  3. Zand MS
  4. Holden-Wiltse J
  5. Mosmann TR
  6. Perelson AS
  7. Wu H
  8. Topham DJ
  (2010 Jul 01). Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. J Virol. 84, 6687-98.
• 1. Desmet EA
  2. Hollenbaugh JA
  3. Sime PJ
  4. Wright TW
  5. Topham DJ
  6. Sant AJ
  7. Takimoto T
  8. Dewhurst S
  9. Maggirwar SB
  (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. 400, 224-32.
• 1. Chapman TJ
  2. Topham DJ
  (2010 Apr 01). Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. J Immunol. 184, 3841-9.
• 1. Joo HM
  2. He Y
  3. Sundararajan A
  4. Huan L
  5. Sangster MY
  (2010 Mar 02). Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination. Vaccine. 28, 2186-94.
• 1. Bernard MP
  2. Bancos S
  3. Chapman TJ
  4. Ryan EP
  5. Treanor JJ
  6. Rose RC
  7. Topham DJ
  8. Phipps RP
  (2010 Feb 03). Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine. 28, 1363-72.
• 1. Baer J
  2. Santiago F
  3. Yang H
  4. Wu H
  5. Holden-Wiltse J
  6. Treanor J
  7. Topham DJ
  (2010 Jan 22). B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine. 28, 907-15.
• 1. Li Z
  2. Wang H
  3. Xue L
  4. Shin DM
  5. Roopenian D
  6. Xu W
  7. Qi CF
  8. Sangster MY
  9. Orihuela CJ
  10. Tuomanen E
  11. Rehg JE
  12. Cui X
  13. Zhang Q
  14. Morse HC
  15. Morris SW
  (2009 Nov 05). Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood. 114, 4158-68.
• 1. Lee HY
  2. Topham DJ
  3. Park SY
  4. Hollenbaugh J
  5. Treanor J
  6. Mosmann TR
  7. Jin X
  8. Ward BM
  9. Miao H
  10. Holden-Wiltse J
  11. Perelson AS
  12. Zand M
  13. Wu H
  (2009 Jul 01). Simulation and prediction of the adaptive immune response to influenza A virus infection. J Virol. 83, 7151-65.
• 1. Elphick GF
  2. Sarangi PP
  3. Hyun YM
  4. Hollenbaugh JA
  5. Ayala A
  6. Biffl WL
  7. Chung HL
  8. Rezaie AR
  9. McGrath JL
  10. Topham DJ
  11. Reichner JS
  12. Kim M
  (2009 Apr 23). Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 113, 4078-85.
• 1. Zeng J
  2. Joo HM
  3. Rajini B
  4. Wrammert JP
  5. Sangster MY
  6. Onami TM
  (2009 Apr 15). The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. J Immunol. 182, 4721-7.
• 1. Crompton PD
  2. Mircetic M
  3. Weiss G
  4. Baughman A
  5. Huang CY
  6. Topham DJ
  7. Treanor JJ
  8. Sanz I
  9. Lee FE
  10. Durbin AP
  11. Miura K
  12. Narum DL
  13. Ellis RD
  14. Malkin E
  15. Mullen GE
  16. Miller LH
  17. Martin LB
  18. Pierce SK
  (2009 Mar 01). The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals. J Immunol. 182, 3318-26.
• 1. Lin GH
  2. Sedgmen BJ
  3. Moraes TJ
  4. Snell LM
  5. Topham DJ
  6. Watts TH
  (2009 Jan 15). Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. J Immunol. 182, 934-47.
• 1. Bancos S
  2. Bernard MP
  3. Topham DJ
  4. Phipps RP
  (2009 Jan 01). Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cell Immunol. 258, 18-28.
• 1. Kyu SY
  2. Kobie J
  3. Yang H
  4. Zand MS
  5. Topham DJ
  6. Quataert SA
  7. Sanz I
  8. Lee FE
  (2009 Jan 01). Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. J Immunol Methods. 340, 42-7.
• 1. Joo HM
  2. He Y
  3. Sangster MY
  (2008 Mar 04). Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proc Natl Acad Sci U S A. 105, 3485-90.
• 1. Klein I
  2. Cornejo JC
  3. Polakos NK
  4. John B
  5. Wuensch SA
  6. Topham DJ
  7. Pierce RH
  8. Crispe IN
  (2007 Dec 01). Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood. 110, 4077-85.
• 1. Borowski AB
  2. Boesteanu AC
  3. Mueller YM
  4. Carafides C
  5. Topham DJ
  6. Altman JD
  7. Jennings SR
  8. Katsikis PD
  (2007 Nov 15). Memory CD8+ T cells require CD28 costimulation. J Immunol. 179, 6494-503.
• 1. Richter MV
  2. Topham DJ
  (2007 Oct 15). The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection. J Immunol. 179, 5054-63.
• 1. Polakos NK
  2. Klein I
  3. Richter MV
  4. Zaiss DM
  5. Giannandrea M
  6. Crispe IN
  7. Topham DJ
  (2007 Jul 01). Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. J Immunol. 179, 201-10.
• 1. Richards KA
  2. Chaves FA
  3. Krafcik FR
  4. Topham DJ
  5. Lazarski CA
  6. Sant AJ
  (2007 Jul 01). Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin. J Virol. 81, 7608-19.
• 1. Richter M
  2. Ray SJ
  3. Chapman TJ
  4. Austin SJ
  5. Rebhahn J
  6. Mosmann TR
  7. Gardner H
  8. Kotelianski V
  9. deFougerolles AR
  10. Topham DJ
  (2007 Apr 01). Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection. J Immunol. 178, 4506-16.
• 1. Vanitha DJ
  2. Joo HM
  3. Rouse BT
  4. Sangster MY
  (2007 Mar 30). Quantitative analysis of herpes simplex virus type 1-specific memory B cells generated by different routes of infection. Virology. 360, 136-42.
• 1. Treanor J
  2. Wu H
  3. Liang H
  4. Topham DJ
  (2006 Nov 17). Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Vaccine. 24, 6913-23.
• 1. Kessels HW
  2. Schepers K
  3. van den Boom MD
  4. Topham DJ
  5. Schumacher TN
  (2006 Jul 15). Generation of T cell help through a MHC class I-restricted TCR. J Immunol. 177, 976-82.
• 1. Li X
  2. Vanitha DJ
  3. Joo HM
  4. He Y
  5. Rouse BT
  6. Sangster MY
  (2006 Jun 30). A strategy for selective, CD4+ T cell-independent activation of virus-specific memory B cells for limiting dilution analysis. J Immunol Methods. 313, 110-8.
• 1. Polakos NK
  2. Cornejo JC
  3. Murray DA
  4. Wright KO
  5. Treanor JJ
  6. Crispe IN
  7. Topham DJ
  8. Pierce RH
  (2006 Apr 01). Kupffer cell-dependent hepatitis occurs during influenza infection. Am J Pathol. 168, 1169-78; quiz 1404-5.
• 1. Topham DJ
  2. Chapman TJ
  3. Richter M
  (2006 Mar 01). Lymphoid and extralymphoid CD4 T cells that orchestrate the antiviral immune response. Expert Rev Clin Immunol. 2, 267-76.
• 1. Divekar AA
  2. Zaiss DM
  3. Lee FE
  4. Liu D
  5. Topham DJ
  6. Sijts AJ
  7. Mosmann TR
  (2006 Feb 01). Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells. J Immunol. 176, 1465-73.
• 1. Chapman TJ
  2. Castrucci MR
  3. Padrick RC
  4. Bradley LM
  5. Topham DJ
  (2005 Sep 30). Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection. Virology. 340, 296-306.
• 1. Lipatov AS
  2. Andreansky S
  3. Webby RJ
  4. Hulse DJ
  5. Rehg JE
  6. Krauss S
  7. Perez DR
  8. Doherty PC
  9. Webster RG
  10. Sangster MY
  (2005 Apr 01). Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol. 86, 1121-30.
• 1. Ray SJ
  2. Franki SN
  3. Pierce RH
  4. Dimitrova S
  5. Koteliansky V
  6. Sprague AG
  7. Doherty PC
  8. de Fougerolles AR
  9. Topham DJ
  (2004 Feb 01). The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity. 20, 167-79.
• 1. Sangster MY
  2. Riberdy JM
  3. Gonzalez M
  4. Topham DJ
  5. Baumgarth N
  6. Doherty PC
  (2003 Oct 06). An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J Exp Med. 198, 1011-21.
• 1. Topham DJ
  2. Crispe IN
  (2003 May 01). Contrasting urban and rural lifestyles of memory CD8+ T cells. Immunity. 18, 584-6.
• 1. Topham DJ
  2. Castrucci MR
  3. Wingo FS
  4. Belz GT
  5. Doherty PC
  (2001 Dec 15). The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia. J Immunol. 167, 6983-90.
• 1. Topham DJ
  2. Cardin RC
  3. Christensen JP
  4. Brooks JW
  5. Belz GT
  6. Doherty PC
  (2001 Aug 01). Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity. J Gen Virol. 82, 1971-81.
• 1. Marshall DR
  2. Turner SJ
  3. Belz GT
  4. Wingo S
  5. Andreansky S
  6. Sangster MY
  7. Riberdy JM
  8. Liu T
  9. Tan M
  10. Doherty PC
  (2001 May 22). Measuring the diaspora for virus-specific CD8+ T cells. Proc Natl Acad Sci U S A. 98, 6313-8.
• 1. Doherty PC
  2. Christensen JP
  3. Belz GT
  4. Stevenson PG
  5. Sangster MY
  (2001 Apr 29). Dissecting the host response to a gamma-herpesvirus. Philos Trans R Soc Lond B Biol Sci. 356, 581-93.