Environmental Neurotoxicants as Risk Factors for Behavioral Diseases and Disorders
This laboratory focuses on understanding the contribution of environmental chemical exposures to human diseases and disorders of the central nervous system in order to evaluate human health risks, determine effective strategies for treatment, and inform regulatory agencies. Our research is focused on assessing behavioral, neurotoxicological, and neurodegenerative processes and their interactions as a result of exposure to chemical and non-chemical stressors. These studies include both animal models and human populations with the goal of using human studies to further inform animal models and animal model findings to refine human or population study approaches. We continue to emphasize the significance of context in animal model studies, examining interactions of chemicals with other human environmentally relevant chemical or non-chemical stressors that share biological substrates. The goal of these efforts is to advance animal models towards more realistic simulations of the human environment.
Ongoing projects in the laboratory are:
- Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice. Environ Health Perspect. 122, 939-45. (2014 Sep 01).
- Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations. Neurotoxicology. 44C, 169-183. (2014 Jul 07).
- Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation. Toxicol Sci. 140, 160-78. (2014 Jul 01).