Anatomy and Neurochemistry of Major Psychiatric Illnesses
A longstanding focus of our laboratory is examining how pathways through the amygdala are positioned to mediate symptomatology of severe mental illnesses. Over the last decade, multiple human neuroimaging studies show that amygdala dysfunction—its structure, function, or both—is a component of many psychiatric syndromes. Broadly speaking, this is not surprising since the amygdala has long been known to code the salience of external experience. However, the amygdala participates in many diverse and specific functions including fear conditioning and extinction, safety signaling, recognition of emotion in facial expression, and affective responses to primary rewards and punishments. Many of these functions have seemingly opposing goals, raising the question of whether discrete or similar amygdala subregions or cell groups participate in recognizing safety versus reward, or fear learning and extinction. Moreover, the amygdala is a highly heterogeneous structure whose various nuclei have significant differences in structure and connectivity among animal species. Ongoing studies in our laboratory use nonhuman primate models to identify how input/output pathway through the amygdala converge and segegrate in order to understand how various types of emotional coding might take place in the human. Because many psychiatric symptoms are brought about by stressful life experiences, we work n collaboration with other nonhuman primate groups, to examine the molecular and cellular features of specific amygdala circuits and subcircuits that are especially important in stress responses. Our work is important in helping to design and interpret outcomes of human neuroimaging work, and we also work with several groups studying manifestations of psychiatric disease in humans.
A new area of study in our laboratory involves models of stress in adolescent rats. Since circuit formation in the amygdala is ongoing during childhood and adolescence, we have several studies investigating the roles of stress on typical amygdala development, and correlated behavioral outcomes.
We invite you to visit our research projects page to see specific projects ongoing in the laboratory.
Welcome 2015 Summer Students
This summer we welcome four University of Rochester undergraduates to do mentored projects in the lab.
Giovanna Braganza is a rising junior with interests in how amygdala mediates cognition and social behavior, will investigate connectivity of the extended amygdala, focusing on thalamic inputs
Leah Fails is a rising junior with interests in Psychiatry and Adolescent Medicine, will study neurogenesis in the primate hippocampus, relating it to measures of anxiety-like behavior
Brian Ho is a rising senior in Brain and Cognitive Science and Psychology, will complete independent study begun last winter, detailing how different components of the extended amygdala target the dopamine system.
Shahyan Rehman is a rising senior, with a double major in Neuroscience and Religion, will also complete a project started last winter, examining whether there is evidence of increased cell death in amygdala after a period of unpredictable stress during adolescence.
- Letter to the Editor.Psychoneuroendocrinology. 60, 57. (2015 Oct 01).
- Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field.Hum Brain Mapp. (2015 Jul 14).
- Extending the amygdala in theories of threat processing.Trends Neurosci. 38, 319-29. (2015 May 01).