Salivary Gland Development and Regeneration
The secretory glands of the head and neck, which are responsible for tears, saliva, and protection of the nasal mucosa, are acutely sensitive to insults posed by radiation treatment or autoimmune diseases, such as Sjogren’s syndrome. For the large number of patients diagnosed with head and neck cancer each year, there are currently no effective means to successfully prevent, or to repair, the damage caused to these glands by radiation treatment. The long-range goal of our work is to establish therapeutic strategies for the repair or regeneration of these damaged secretory glands.
Current Research Projects
- Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Mol Ther. 21, 1182-94. (2013 Jun 01).
- Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem. 113, 1955-65. (2012 Jun 01).
- Ascl3 marks adult progenitor cells of the mouse salivary gland. Stem Cell Res. 8, 379-87. (2012 May 01).
- Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration. Dev Biol. 353, 186-93. (2011 May 15).