Anolik Lab
Jennifer Anolik, M.D., Ph.D.
Ph.D. 1994, M.D. 1996
University of Rochester School of Medicine and Dentistry
Associate Professor of Medicine
Division of Allergy/Immunology and Rheumatology
Research Overview
Dr. Anolik's research interests include the role of B cells in the pathophysiology of systemic lupus and related autoimmune diseases, as well as the study of new immuno-modulatory treatments for lupus. As part of the research group at the University of Rochester, she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. Her laboratory currently focuses on the investigation of B cell tolerance and homeostatic mechanisms in early B cell development in human lupus, the effects of B cell targeted therapies on this process, and the development of a murine model of B cell depletion.
Dr. Anolik has served as a mentor for many students in the past and continues to mentor future scientists in her lab. She is also very active in the Lupus Clinic and Program and in community education.
Five Select Publications
Anolik, J.H., Barnard, J., Cappione, A., Pugh-Bernard, A.E., Felgar, R.E., Looney, R.J., Sanz, I. "Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus." Arthritis Rheum. 2004 Nov;50(11):3580-90. View article in PubMed.
Anolik, J.H., Friedberg, J.W., Zheng, B., Barnard, J., Owen, T., Cushing, E., Kelly, J., Milner, E.C., Fisher, R.I., Sanz, I. "B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontongeny."
Clin Immunol. 2007 Feb;122(2):139-45 View article in PubMed
Anolik, J.H., Barnard, J., Owen, T., Zheng, B., Kemshetti, S., Looney, R.J., Sanz, I. "Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy." Arthritis Rheum. 2007 Sep;56(9):3044-56. View article in PubMed.
Anolik, J.H., Ravikumar, R., Barnard, J., Owen, T., Almudevar, A., Milner, E.C., Miller, C.H., Dutcher, P.O., Hadley, J.A., Sanz, I. "Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks." J Immunol. 2008 Jan 15;180(2):688-92.View article in PubMed.
Sanz, I., Wei, C., Lee, F.E., Anolik, J.H. "Pheonotypic and functional heterogeneity of human memory B cells." Semin Immunol. 2008 Feb;20(1);67-82.View article in PubMed
The Anolik Lab
Contact
Jennifer Anolik, M.D., Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-1632
Jennifer_Anolik@urmc.
rochester.edu
Lab Members
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Post-doctoral Fellow |
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Post-doctoral Fellow |
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Post-doctoral Fellow |
Laboratory Technicians: Chris Cistrone, Jennifer Hossler, Teresa Owen
Project Assistant: Alfred Rabinovich |
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