Anolik Lab

Jennifer Anolik, M.D., Ph.D.

Ph.D. 1994, M.D. 1996
University of Rochester School of Medicine and Dentistry

Associate Professor of Medicine
Division of Allergy/Immunology and Rheumatology

Research Overview

 Dr. Anolik is a physician-scientist in systemic autoimmunity and human B cell biology with a research program in translational immunology focusing on the underlying pathogenic mechanisms of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and the development of novel treatment paradigms.She has been one of the pioneers in the use of B cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE and RA patients. Her laboratory currently focuses on the investigation of B cell tolerance and homeostatic mechanisms in early B cell development, the effects of B cell targeted therapies on this process, autoantibody independent functions for B cells including interaction with the T cell and innate immune compartment, and the use of murine models of B cell depletion and autoimmunity. She is the Director of the URMC Lupus Clinic and an investigator on the University of Rochester Autoimmunity Center of Excellence (ACE). 


Dr. Anolik has served as a mentor for many students in the past and continues to mentor future scientists in her lab. She is also very active in the Lupus Clinic and Program and in community education.

Five Select Publications

1.Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH. Novel populations of human transitional B cells revealed by B cell depletion therapy, Journal of Immunology 182(10), 2009. PMID: 19414749

2. Bekar K, Owen T, Dunn R, Ichikawa T, Wang R, Barnard J, Brady S, Nevarez S, Goldman B, Kehry M, Anolik JH.  Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus, Arthritis and Rheumatism 62: 2443-57, 2010. PMID: 20506300

3. Ichikawa H, Conley T, Muchamuel T, Jiang J, Lee S, Owen T Barnard J, Nevarez S, Goldman B, Kirk C, Looney RJ, Anolik, JH.  Novel Proteasome Inhibitors have a beneficial effect in murine lupus via the dual inhibition of Type I interferon and autoantibody secreting cells.  Arthritis and Rheumatism 64: 493-503, 2012. PMID: 21905015

4. Palanichamy A, Bauer JW, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistone C, Bird A, Rabinovich A, Nevarez S, Knight J, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler EC, Kaplan MJ, and Anolik JH. Neutrophil mediated IFN activation in the bone marrow alters B cell development in human and murine SLE, Journal of Immunology, 192(3):906-18, 2014.

5. Wang W, Rangel-Moreno J, Owen T, Ichikawa T, Barnard J and Anolik J. Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells by altering the plasma cell niche, Journal of Immunology 192(7):3011-20, 2014.

        

 

The Anolik Lab

 

             anolik lab

Contact

Jennifer Anolik, M.D., Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-1632
Jennifer_Anolik@urmc.
rochester.edu

Lab Members

Nida Meednu

Nida Meednu, PhD

Research Assistant Professor

Dr. Rangel-Moreno

Javier Rangel-Moreno , Ph.D.

Senior Instructor

Graduate Students:
Anna Bird

 

Laboratory Technicians: Jennifer Hossler, Teresa Owen

 

Project Assistant:

Victor Wang