Anolik Lab

Jennifer Anolik, M.D., Ph.D.

Ph.D. 1994, M.D. 1996
University of Rochester School of Medicine and Dentistry

Associate Professor of Medicine
Division of Allergy/Immunology and Rheumatology

Research Overview

 Dr. Anolik is a physician-scientist in systemic autoimmunity and human B cell biology with a research program in translational immunology focusing on the underlying pathogenic mechanisms of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and the development of novel treatment paradigms.She has been one of the pioneers in the use of B cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE and RA patients. Her laboratory currently focuses on the investigation of B cell tolerance and homeostatic mechanisms in early B cell development, the effects of B cell targeted therapies on this process, autoantibody independent functions for B cells including interaction with the T cell and innate immune compartment, and the use of murine models of B cell depletion and autoimmunity. She is the Director of the URMC Lupus Clinic and an investigator on the University of Rochester Autoimmunity Center of Excellence (ACE). 


Dr. Anolik has served as a mentor for many students in the past and continues to mentor future scientists in her lab. She is also very active in the Lupus Clinic and Program and in community education.

Five Select Publications

1. Bekar K, Owen T, Dunn R, Ichikawa T, Wang R, Barnard J, Brady S, Nevarez S, Goldman B, Kehry M, Anolik JH.  Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus, Arthritis and Rheumatism 62: 2443-57, 2010. PMID: 20506300

2.Anolik JH. Immunologic reconstitution after rituximab in systemic lupus erythematosus: why should we care?, J Rheumatology editorial 38:587-9, 2011.

3.Ichikawa H, Conley T, Muchamuel T, Jiang J, Lee S, Owen T Barnard J, Nevarez S, Goldman B, Kirk C, Looney RJ, Anolik, JH.  Novel Proteasome Inhibitors have a beneficial effect in murine lupus via the dual inhibition of Type I interferon and autoantibody secreting cells.  Arthritis and Rheumatism 64: 493-503, 2012. PMID: 2190501.

4.Marian V and Anolik JH. Treatment Targets in SLE: Biology and Clinical Perspective.  Arthritis Research Therapy.  14 Suppl 4:S3 2012. (guest editor for this issue) PMCID: PMC3535717

5. Anolik JH. B cell biology: implications for treatment of systemic lupus erythematosus. Lupus 22(4): 342-9. 2013. PMID: 23553777

        

 

The Anolik Lab

 

             anolik lab

Contact

Jennifer Anolik, M.D., Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-1632
Jennifer_Anolik@urmc.
rochester.edu

Lab Members

 

Nida Meednu, PhD

Post-doctoral Fellow

Dr. Rangel-Moreno

Javier Rangel-Moreno , Ph.D.

Senior Instructor

 

Laboratory Technicians: Jamie Biear, Jennifer Hossler, Teresa Owen

 

Project Assistant:

Alfred Rabinovich