Ritchlin Lab

Christopher Ritchlin, M.D., MPH

M.D. 1982
Albany Medical College

Professor of Medicine

Chief, Division of Allergy, Immunology and Rheumatology
Division of Allergy/Immunology and Rheumatology

Research Overview

     The focus of Dr. Ritchlin’s laboratory is directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.
      Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit.
      Dr. Ritchlin has mentored post-doctoral fellows and students in his lab in the past and continues to serve as a mentor for future scientists. He is very active in the Psoriatic Arthritis Clinic.

Select Publications

   Proulx, S.T., Kwok, E., You, Z., Beck, C.A., Shealy, D.J., Ritchlin, C.T., Boyce, B.F., Xing, L., Schwarz, E.M. "MRI and quantification of draining lymph node function in inflammatory arthritis." Ann N Y Acad Sci. 2007 Nov;1117:106-23. View article in PubMed.                 
   Schwarz, E.M., Ritchlin, C.T. "Clinical development of anti-RANKL therapy." Arthritis Res Ther. 2007;9Suppl 1:S7. View article in PubMed.
    Gladman DD; Mease PJ; Strand V; Healy P; Helliwell PS; Fitzgerald O; Gottlieb AB; Krueger GG; Nash P; Ritchlin CT; Taylor W; Adebajo A; Braun J; Cauli A; Carneiro S; Choy E; Dijkmans B; Espinoza L; van der Heijde D; Husni E; Lubrano E; McGonagle D; Qureshi A; Soriano ER; Zochling J. "Consensus on a core set of domains for psoriatic arthritis." J Rheumatol. 2007;34(5):1167-70. . View article in PubMed.   Pariser DM; Bagel J; Gelfand JM; Korman NJ; Ritchlin CT; Strober BE; Van Voorhees AS; Young M; Rittenberg S; Lebwohl MG; Horn EJ; . "National Psoriasis Foundation clinical consensus on disease severity." Archives of dermatology. 2007;143(2):239-42. View article in PubMed.
   Keeling SO; Landewe R; van der Heijde D; Bathon J; Boers M; Garnero P; Geusens P; El-Gabalawy H; Inman RD; Kraus VB; Kvien TK; Mease PJ; Ostergaard M; Ritchlin C; Syversen SW; Maksymowych WP. "Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein." The Journal of rheumatology. 2007;34(3):623-33 . View article in PubMed.

                                                    The Ritchlan lab

    Ritchlin lab staff

Contact

Christopher Ritchlin, M.D., MPH
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-2125
Christopher_Ritchlin@urmc.
rochester.edu

Lab Members

Grace Chiu, Ph.D.  
Research Assistant Professor


  Graduate Students:
Liz Marie Albertorio Sáez
  Technicians:
Dongee Li