Ritchlin Lab

Christopher Ritchlin, M.D., MPH

M. D. 1982
Albany Medical College

Chief, Division of Allergy, Immunolgy
   and Rheumatology

                                                                       Dr. Ritchlin                                                                             

                                                                          View Dr Ritchlin's Profile

Research Overview

The focus of Dr. Ritchlin’s laboratory is directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.

Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit.

Dr. Ritchlin has mentored post-doctoral fellows and students in his lab in the past and continues to serve as a mentor for future scientists. He is very active in the Psoriatic Arthritis Clinic.

Select Publications

1. Ritchlin C, Haas-Smith S, Stroyer B, Schwarz E. Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 111(6): 821-833, 2003. PMC153764

2. Chiu Y, Mensah K, Schwarz E, Ju Y, Feng C, McMahon L, Hicks D, Panepento B, Keng, P, Ritchlin CT. Regulation of Human Osteoclast Development by Dendritic Cell Surface Transmembrane Protein (DC-STAMP). J Bone Min Res. 2012 Jan:27(1):79-92.
doi: 10.1002/jbmr.531. PMC3304467

3. Chiu, YG, and Ritchlin CT (2013) Characterization of DC-STAMP+ Cells in Human Bone Marrow. J Bone Marrow Res 1: 127. doi:10.4172/2329-8820.1000127.

4. Chiu, YG, and Ritchlin CT (2012) Biomarkers to diagnose early arthritis in patients with psoriasis. Psoriasis Forum 18 (2):48-56.

5. Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT. CD16 (FcRgIII) as a potential marker of osteoclast precursors in psoriatic arthritis. Arthritis Res Ther 2010, 12(1):R14. PMC2875642




                                                   The Ritchlan Lab

          Ritchlin Lab




Christopher Ritchlin, M.D., MPH
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-2125

Lab Members

Grace Chiu, Ph.D.
Research Assistant Professor

Grace Chiu

Graduate Students:
Liz Marie Albertorio Sáez

Dongee Li