Anolik Lab

The Team

Jennifer Anolik, M.D.,Ph.D., Assistant Professor of Medicine
Kai Bekar, Ph.D., post-doctoral fellow
Jennifer Hossler, laboratory technician
Teresa Owen, laboratory technician
Arumugam Palanichamy, Ph.D., post-doctoral fellow

Dr. Anolik's Research Interests

Dr. Anolik's research interests include the role of B cells in the pathophysiology of systemic lupus and related autoimmune diseases, as well as the study of new immuno-modulatory treatments for lupus. As part of the research group at the University of Rochester, she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. Her laboratory currently focuses on the investigation of B cell tolerance and homeostatic mechanisms in early B cell development in human lupus, the effects of B cell targeted therapies on this process, and the development of a murine model of B cell depletion

Dr. Anolik has served as a mentor for students in her lab in the past and continues to mentor furture scientists.

Funding

Dr. Anolik's funding sources include: The NIH, the Lupus Foundation, the Alliance for Lupus Research, the Lupus Research Institute, the Feinstein Institute, Amgen and Genetech.

Relevant Publications

Anolik JH, Barnard J, Cappione A, Pugh-Bernard, A, Young F, Sanz I, and Looney J. Rituximab improves peripheral B cell abnormalities in human SLE, Arthritis and Rheumatism 50:3580, 2004.

Anolik JH, Friedberg J, Barnard J, Owen T, Cushing E, Campbell D, Kelly J, Looney RJ, Fisher RI, Sanz I. B cell reconstitution after rituximab recapitulates B cell ontogeny with a preponderance of transitional B cells and a paucity of memory B cells, Clinical Immunology 122:139, 2007.
Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I. Delayed memory B cell recovery in peripheral blood and lymphoid tissue in SLE after B cell depletion therapy, Arthritis and Rheumatism 56: 3044-56, 2007.

Anolik JH, Ravikumar R, Barnard J, Owen T, Almudevar A, Milner ECB, Miller C, Dutcher P, Hadley J, Sanz I. Anti-TNF Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks, Journal of Immunology cutting edge 180(2):688, 2008.
Sabahi R and Anolik JH. B cell targeted therapy for systemic lupus erythematosus. Drugs 66:1, 2006

Complete list of Dr. Anolik's publications