Email this pageRitchlin Lab
The Team
Christopher Ritchlin, M.D., Associate Professor of Medicine
Rick Barrett,
Clinical Research Study Coordinator
Grace Chiu, Technician
Katie Gall, Health Project Coordinator
Kofi Mensah, Graduate student
Sharon Moorehead, Health Project Coordinator
LI Zhang, Technician
Dr. Ritchlin's Research Interests
The focus of Dr. Ritchlin’s laboratory is directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.
Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.
Dr. Ritchlin has mentored post-doctoral fellows and students in his lab in the past and continues to serve as a mentor for future scientists.
Funding
Dr. Ritchlin receives funding from the NIH, Centecor, National Psoriasis Foundation, and the Canadian Institute of Health Research.
Relevant Publications
- Ritchlin, CT. Psoriatic arthritis: From Skin to bone. Nature Clinical Practice Rheumatology. (invited review) (in press).
- Proul ST, Kwok E, You Z, Beck CA, Sjealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM. MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis. Ann N Y Acad Sci. 2007 Jul 23; Epub ahead of print
- Schwarz EM, Ritchlin CT. Clinical development of anti-RANKL therapy.Arthritis Res Ther. 2007;9 Suppl 1:S7.
- Gladmann DD, Mease Pj, Strand V, Healy P, Helliwell PS, Fitzgerald O, Gottlieb AB, Krueger GG, Nash P, Ritchlin CT, Taylor W, Adebajo A, Braun J, Eaul A, Carneiro S, Choy E, Pijkmans B, Wspinoza L, vander Heijde D, Shuni E, Lubrano E, McGonagle D, Qureshi A, Soliano ER, Zochling J. Consensus on a core set of domains for psoriatic arthritis.
- JParisen DM, Bagel J, Gelfand JM, Korman NJ, Ritchlin CT, Strober BE, VAn Voorhees, AS, Young M, Rittenberg S, Lebioohl MG, Horn EJ. National Psioriasis Foundation. National Psoriasis Foundation clinical consensus on disease severity.
Arch Dermatol. 2007 Feb;143(2):239-42.
