Zuscik Lab

Michael J. Zuscik

Ph.D. 1993 University of Rochester


Associate Professor of Orthopaedics, Director of Educational Programs, CMSR

Primary Affilication: Department of Orthopaedics

Center Affiliation: Center for Musculoskeletal Research

Research Overview

The central focus of our research can be divided programmatically into two parts:  1) the study of the contribution of chondrogenesis and chondrocyte differentiation to the process of fracture repair and 2) the study of the behavior of the articular chondrocyte under normal conditions in healthy joints and during pathologic situations such as joint degeneration.  The complex interplay between several key signaling mechanisms, including the TGF-beta, Wnt/beta-catenin and PTH/PTHrP pathways, are important for modulating chondrocyte differentiation and physiology and thus have a critical contribution to play during the fracture healing and joint maintenance/disease.  Understanding the specific role of each will lead us to a better understanding of these processes in general and will enable us to design strategies for addressing diverse clinical problems spanning from non-union of fractures to osteoarthritis.

Projects

Fracture 2 Impact of Cigarette Smoking on Fracture Repair
OA 1 The Molecular Pathogenesis of Osteoarthritis
Knees Development of Chondro-regenerative Therapies for Osteoarthritis

Selected Publications

E.R. Sampson, M.J. Hilton, Y. Tian, D. Chen, E.M. Schwarz, R.M. Mooney, S.V. Bukata, R.J. O’Keefe, H. Awad, J.E. Puzas, R.N. Rosier and M.J. Zuscik, Teriparatide as a chondro-regenerative therapy for injury-induced knee osteoarthritis, Science Trans Med, in press 2011.

M.H. Kung, J. Yukata, R.J. O'Keefe and M.J. Zuscik, Aryl Hydrocarbon Receptor-Mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a) pyrene, J. Cell Physiol, in press 2011.

E.R. Sampson, C.A. Beck, J. Ketz, K.L. Canary, M.J. Hilton, H. Awad, E.M. Schwarz, D. Chen, R.J. O'Keefe, R.N. Rosier and M.J. Zuscik, Establishment of an index with increased sensitivity for assessing murine arthritis, J Orthop Res, in press 2011.

M. Zhu, D. Tang, Q. Wu, S. Hao, M. Chen, C. Xie, R.N. Rosier, R.J. O'Keefe, M.J. Zuscik nd D. Chen, Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice, J Bone Miner Res, 24 (2009) 12-21.

J.C. Elfar, J.A. Jacobson, J.E. Puzas, R.N. Rosier and M.J. Zuscik, Erythropoietin accelerates functional recovery after peripheral nerve injury, J Bone Joint Surg Am, 90 (2008) 1644-1653.

Q. Wu, K.O. Kim, E.R. Sampson, D. Chen, H. Awad, T. O'Brien, J.E. Puzas, H. Drissi, E.M. Schwarz, R.J. O'Keefe, M.J. Zuscik and R.N. Rosier, Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice, Arthritis Rheum, 58 (2008) 3132-3144.

Zuscik M, Hilton MJ, Zhang X, Chen D, and O’Keefe RJ. (2008).  Regulation of Chondrogenesis and Chondrocyte Differentiation by Stress. Journal of Clinical Investigation, 118(2): 429-38.

More papers: PubMed

Graduate Program Affiliations

Contact

Michael J. Zuscik, Ph.D.
University of Rochester
601 Elmwood Ave., Box 665
Rochester, NY 14642

Office: SMD 1-8537

(585) 275-1397
michael_zuscik@URMC.
Rochester.edu

Lab Members

Robert Maynard Robert Maynard
Tech IV
Daisuke Hamada Daisuke Hamada Visiting Scientist
Christopher Farnsworth

Christopher Farnsworth

PhD Student

Robert Hoff

Robert Hoff

PhD student

Matthew Brown

Matthew Brown

MD Student

Michael David

Michael David

BS Student

Khyrie Jones

Khyrie Jones

BS Student

Andrea Lee

Andrea Lee

BS Student

Haiyan Li

Haiyan Li

Tech Associate

Margaret Thomas

Margaret Thomas

PhD Student

Christopher Tseng

Christopher Tseng

PhD Student

Theron Fussell

Theron Fussell

MD Student

Ronald Menorca

Ronald Menorca

MD Student