NYICE Publications

 

Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus. Sun X, Tse LV, Ferguson AD, Whittaker GR. J Virol. 2010 Sep;84(17):8683-90. Epub 2010 Jun 16.PMID: 20554779 [PubMed - indexed for MEDLINE] PMID20554779

 

Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B. PLoS One. 2010 Apr 29;5(4):e10372.PMID: 20454455 [PubMed - in process] PMID20454455

 

Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Nayak JL, Richards KA, Chaves FA, Sant AJ. Viral Immunol. 2010 Apr;23(2):169-80.PMID: 20373997 [PubMed - indexed for MEDLINE] PMID20373997

 

Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. Chapman TJ, Topham DJ. J Immunol. 2010 Apr 1;184(7):3841-9. Epub 2010 Mar 3.PMID: 20200271 [PubMed - indexed for MEDLINE] PMID20200271

 

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. Virology. 2010 May 10;400(2):224-32. Epub 2010 Feb 25.PMID: 20185156 [PubMed - indexed for MEDLINE] PMID20185156

 

B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ. Vaccine. 2010 Jan 22;28(4):907-15. Epub 2009 Nov 21.PMID: 19932673 [PubMed - indexed for MEDLINE] PMID19932673

 

Abortive activation of CD4 T cell responses during competitive priming in vivo.

Weaver JM, Chaves FA, Sant AJ. Proc Natl Acad Sci U S A. 2009 May 6;106(21):8647-52. Epub 2009 May 7.PMID: 19423666 [PubMed - indexed for MEDLINE] PMID19423666

 

Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. Richards KA, Chaves FA, Sant AJ. J Virol. 2009 Jul;83(13):6566-77. Epub 2009 Apr 22.PMID: 19386707 [PubMed - indexed for MEDLINE] PMID19386707

 

Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. J Immunol. 2008 Sep 1;181(5):3039-48.PMID: 18713974 [PubMed - indexed for MEDLINE] PMID18713974

 

Guo H, Santiago F, Lambert K, Takimoto T, and Topham DJ. “T cell mediated protection against lethal 2009 pandemic H1N1 influenza infection in a mouse model” J Virology (accepted Oct 14, 2010)

 

Guo H; Topham DJ. "IL-22 production by pulmonary natural killer cells and the potential role of IL-22 during primary influenza infection." Journal of virology. 2010; Epub 2010 May 26. PMID20504940

 

Chapman TJ; Topham DJ. "Identification of a Unique Population of Tissue-Memory CD4+ T Cells in the Airways after Influenza Infection That Is Dependent on the Integrin VLA-1." Journal of immunology (Baltimore, Md.: 1950). 2010; Epub 2010 Mar 03. PMID20200271

 

Desmet EA; Hollenbaugh JA; Sime PJ; Wright TW; Topham DJ; Sant AJ; Takimoto T; Dewhurst S; Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology. 2010; Epub 2010 Feb 24. PMID20185156

 

Bernard MP; Bancos S; Chapman TJ; Ryan EP; Treanor JJ; Rose RC; Topham DJ; Phipps RP. "Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection." Vaccine. 2010; 28(5):1363-72. Epub 2009 Nov 24. PMID19941994

 

Santiago F, Fitzgerald T, Treanor JJ, and Topham DJ. “An animal model of immunity and protection following vaccination with drifted variants of avian influenza H5 hemagglutinin (HA)” Vaccine-submitted.

 

Scheible K, Zhang G, Baer J, Azadniv M,  Pryhuber G, Treanor JJ, and Topham DJ. “Cross-reactive CD8+ T Cell Immunity to 2009 Pandemic H1N1 Influenza Virus” Vaccine-submitted.

 

Chapman TJ and Topham DJ. “Rapid Reactivation of Extralymphoid CD4 T cells During Secondary Infection” PLOS-One (in review)

 

Nayak, J. L., Richards, K. A. Chaves, F.A. and Sant, A. J. 2010. Analyses of the Specificity of CD4 T cells during the Primary Immune Response to Influenza Virus Reveals Narrow Immunodominance and an Unexpected Asymmetry in Reactivity to Viral Proteins.  Viral Immunol. 2010 Apr;23(2):169-80. VIM2009

 

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. 2010. Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. 2010 May 10;400(2):224-32. Epub 2010 Feb 25. PMID20185156

 

Richards KA., Topham DT, Chaves FA, Sant AJ (2010). CD4 T cells generated from encounter with the seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. Cutting Edge: J. Immunol. In Press.2010 Oct JI1001395

 

The influenza PB2 amino acid residue 271 is important for mammalian adaptation of avian viruses. J. Virol. 84:4395-4406. May-2010 JVI02642-09

 

Luis Martínez-Sobrido, Richard Cadagan, John Steel, Christopher F, Basler, Peter Palese, Thomas M. Moran, and Adolfo García-Sastre. Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies. J. Virol. 84: 2157-2163 Feb-2010 JVI1433-09

 

Martínez-Sobrido L, García-Sastre A (2010). Generation of Recombinant Influenza Virus from Plasmid DNA. J Vis Exp. 42. Jove2057

 

Baer, J., F. Santiago, H. Yang, H. Wu, W. Jeanne Holden, J. Treanor, and D. J. Topham. B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine. 2010 Jan 22;28(4):907-15. Epub 2009 Nov 21. PMID: 19932673 [PubMed - indexed for MEDLINE] PMID19932673

 

Yang, H., D. J. Topham, J. Holden-Wiltse, and H. Wu. 2010. Statistical Estimation &Inference of Cell Counts form ELISPOT Limiting Dilution Assays. Journal of Biopharmaceutical Statistics [conditionally accepted].