Current Clinical Research

Studies for Pregnant Women

Study Title: POWER - Postpartum Testing for Diabetes Mellitus in Women with Gestational Diabetes Mellitus
About the Study: We are hoping to enroll participants immediately postpartum while in-patient, must be term, not infected, and not taking steroids. Requires a 2 hour glucose tolerance test while inpatient and one at 6 weeks postpartum. Participants will receive a small gift card.
Enrolling? Yes
PI: Loralei Thornburg, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

Study Title: Multiples Iron Study
PI: Kimberly O'Brien, PhD; Eva Pressman, MD
About the Study: Study is enrolling only women carrying twins or triplets who will deliver at Highland or Strong Hospital, who are between 18-45 years of age. Compensation is $25 to Target and onsies for each of the babies.
Enrolling? Yes
Person to Contact: Sarah J. Caveglia  585-410-5381

Study Title: Gene Expression in Severe Preeclampsia
About the Study: We are hoping to enroll patients on the labor deck and scheduled cesarean section pre-operatively for controls. Patients cannot have received steroids and must be between 32-42 weeks gestation. Those with preeclampsia will meet the diagnostic criteria as determined by Sibai et al, 1997. Participants are not compensated.
Enrolling? Yes
PI: Monique Ho, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

Study Title: Removal versus Retention of Cerclage in Preterm Premature Rupture of Membranes
About the Study: We are enrolling women who meet the following inclusion criteria: a previously placed prophylactic cerclage done < 23 weeks, 6 days of pregnancy with spontaneous rupture of membranes between 22-326/7 weeks of pregnancy, singleton or twin gestation with the circlage in place > 1 week and not in active labor. All participants are randomized for cerclage removal or retention and the outcome measures are presence/absence of chorioamnionitis, composite neonatal outcome, NICU stay, EGA at delivery, postpartum endometritis, maternal sepsis and latency of pregnancy. Patients are not compensated.
Enrolling? Yes
PI: Tulin Ozcan, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

Study Title: Prenatally Diagnosed Lower Urinary Tract Obstruction (LUTO) with Normal Amniotic Fluid
About the Study: The purpose of this study is to determine whether infants who had normal amniotic fluid volume, but enlarged bladders and kidneys before birth, suffer renal injury before birth and develop renal insufficiency or failure before birth or during the first two years of life. Participants are not compensated.
Enrolling? Yes
PI: Tulin Ozcan, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

Study Title: Sources of Fetal Iron During Pregnancy (Prelabeled Iron study)
About the Study: Study is enrolling only women who are less than 16 weeks into their pregnancy, single gestation, between 15-35 years of age, and who do not smoke. Compensation is $160 in Wal-Mart gift cards. Participants must be receiving care through URMC Midwifery practice.
Enrolling? Yes
PI: Eva Pressman, MD; Kimberly O'Brien, PhD
Person to Contact: Sarah J. Caveglia  585-410-5381

Study Title: Vitamin D and Infection during Pregnancy
About the Study: Study is enrolling only young women who are 13-18 years of age and do not smoke. Participants must be receiving care through the RAMP clinic. Compensation is $150 in Wal-Mart gift cards.
Enrolling? Yes
PI: Eva Pressman, MD; Kimberly O'Brien, PhD
Person to Contact: Lauren Cowen 585-410-0119

Study Title: The Infant Development and Environment Study (TIDES)
About the Study: TIDES is a study about how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. You can find out more at www.tidesstudy.org.
Enrolling? No
PI: Shanna Swan, PhD (Mount Sinai School of Medicine); Eva Pressman, MD (University of Rochester)
Person to Contact: Heather Fiore, RD, MS Ed; Erin Driscoll-Brantley, MPH, CPH  585-275-4149

Study Title: The e-Moms Biomarker Study II (a study conducted by the Department of Community and Preventive Medicine)
About the Study: e-Moms is a study that uses a website and cell phones to help women in the greater Rochester area be healthy during and after pregnancy.
Enrolling? Yes
PI: Diana Fernandez, MD, MPH, PhD
Person to Contact: Shaya Greathouse or Kimberly McKee 585-275-3565

Studies of PCOS

Study Title: PCOS Study: The Use of an MMP Inhibitor, doxycycline, to reduce ovarian androgen production and restore normal cycling in women with Polycystic Ovarian Syndrome
About the Study: We are recruiting women ages 18-40 with irregular menstrual cycles for a 24 week study looking at the effects of 12 weeks of study medicine on menstrual cycles and hormones. Payment up to $230.00 for completion of study.
Enrolling? Yes
PI: Kathleen Hoeger, MD, MPH; Stephen Hammes, MD
Person to Contact: Lynda Kochman, RN, CCRC  585-275-4149, 585-273-2995
pcos_research@urmc.rochester.edu

Study Title: Prenatal androgens and PCOS
About the Study: We are recruiting women with polycystic ovary syndrome (PCOS) for a study on whether  PCOS might be related to hormones circulating in mothers’ bodies during pregnancy. The study involves a one-time visit similar to a gynecological exam. Blood draw optional.  Payment up to $40.00 for completion of study.
Enrolling? Yes
PI: Emily Barrett, PhD
Person to Contact: Lynda Kochman, RN, CCRC  585-275-4149, 585-273-2995
pcos_research@urmc.rochester.edu

Studies of Vulvadynia and Pelvic Pain

Study Title: Localized Provoked Vulvodynia Pathogenesis
About the Study: We are planning to enroll 30 women between 18 and 50 who meet Friedrich’s Criteria for localized provoked vulvodynia with 30 controls between 18 and 50 years old, negative Friedrich’s criteria, and planned surgical procedure to lower genital tract. Both groups will undergo biopsy of the vulva. Both groups will be compensated.
Enrolling? Yes
PI: David Foster, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

Study Title: A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
About the Study: We are enrolling women with diagnosed vulvodynia will undergo 6 weeks of therapy with either drug or placebo, a week of no drug and then another 6 weeks of therapy with either drug or placebo. Extensive testing for pain will be done at the peak of medication or placebo levels. Patients are compensated for participation.
Enrolling? Yes
PI: David Foster, MD
Person to Contact: Linda Closs Leoni, RN  585-275-3160

A current list of open clinical trials at the University of Rochester is available here.