Dr. Ryan participates in gastrointestinal, liver transplant and hepatobiliary working conferences for clinicians. Strong Memorial Hospital is a United Network for Organ Sharing (UNOS) transplant center for adult and pediatric transplant surgery and the only hospital in New York serving the upstate and western regions. Dr. Ryan is responsible for diagnosing the great majority of liver transplant biopsies and has received additional training at the University of Pittsburgh in the interpretation of both liver and small bowel transplant biopsies. She has also studied heart transplant pathology at the Mt. Sinai Medical Center in New York City and has helped cover that service for the last 9 years.

Qualifications

M.D., The Johns Hopkins School of Medicine 1975
Residency, Pathology, University of Rochester, 1975-81
Fellow, Surgical Pathology, University of Rochester 1990-91
Board Certification, American Board of Pathology (Anatomic Pathology) 1981

Research Overview

Dr. Ryan’s research endeavors with the liver transplant program include the study of post transplant biopsies in hepatitis C patients more particularly regarding response to antiviral therapy and the treatment of acute cellular rejection. Additional projects have included liver grafts from donors with CNS tumors and analysis of outcomes in patients with primary sclerosing cholangitis. Collaboration with Oncology is ongoing and involves the association of tissue factor (TF) with VEGF expression in colorectal, pancreatic and gastric carcinomas, suggesting a link between hemostatic activation and angiogenesis. Past studies included EGFR and VEGF expression and mutated K12-ras as indicators of survival in colon cancer. Another field of investigation concerns the development and evaluation of microtubule-targeting agents as therapeutic candidates in hepatic and colorectal cancers.

Publications

Kashyap R, Ryan C, Sharma R, Maloo M, Safadjou S, Tretheway D, Jain A, Orloff M. Liver grafts from donors with CNS tumors: A single center perspective. Liver Transplantation (in Press).

Kashyap R, Mantry P, Maloo M, Sharma R, Safadjou S, Jain A , Maliakkal B, Bozorgzadeh A, Ryan C, Orloff M. Comparative analysis of outcomes in living and deceased donor liver transplant for primary sclerosing cholangitis. Journal of Gastrointestinal. 2009 May.

Jain A, Sharma R, Ryan C, Safadjou S, Kashyap R, Mantry P, Maliakkal R, Orloff M. Response to antiviral therapy in liver transplant recipients with recurrent hepatitis C viral infection: a single center experience. Clinical Transplantation. 2009 February;23(4).

Yao JL, Ryan CK, Francis CW, Kohli M, Taubman MB, Khorana AA.  Tissue factor and VEGF expression in prostate carcinoma.  Cancer Investigation.  2009 May;27(4):430-434.

Thretheway D, Jain A, LaPoint R, Sharma R, Bozorgzadeh A, Milot P, Ryan C. Should trichrome stain be used on all post transplant biopsies with Hepatitis C virus infection to estimate fibrosis score?  Liver Transplantation. 2008 May;14(5):695-700.

Jain A, Sharma R, Ryan C, Tsoulfas G, Orloff M, Abt P, Kashyap R, Batzold P, Sauberman L,

Safadjou S, Graham M, Bozorgzadeh A. Potential immunological advantage of intravenous mycophenolate mofetil with tacrolimus and steroids in primary deceased donor liver transplantation without antibody induction. Liver Transplantation. 2008 February;14(2):202-209.

Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancerClin Cancer Res. 2007 May 15;13(10):2870-5.

Teeters JC, Betts R, Ryan C, Huether J, Elias K, Hartmann D, Massey T, Chen L. Rectal and cutaneous malakoplakia in an orthotopic cardiac transplant recipient. J Heart Lung Transplant. 2007 April;26(4):411-3.

Saad WE, Davies MG, Ryan CK, Rubens DJ, Patel NC, Lee DE, Sahler LG, Waldman DL. Incidence of arterial injuries detected by arteriography following percutaneous right-lobe ultrasound-guided core liver biopsies in human subjects. Am J Gastroenterol. 2006 November;101(11):2641-5.

Jain A, Ryan C, Mohanka R, Orloff M, Abt P, Romano J, Bryan L, Batzold P, Mantry P, Bozorgzadeh A. Characterization of CD4, CD8, CD56 positive lymphocytes and C4d deposits to distinguish acute cellular rejection from recurrent hepatitis C in post-liver transplant biopsies. Clin Transplant. 2006 September-October;20(5):624-33.

Saad WE, Ryan CK, Davies MG, Fultz P, Rubens DJ, Patel NC, Sahler LG, Lee DE, Kitanosono T, Sasson T, Waldman DL. Safety and efficacy of fluoroscopic versus ultrasound guidance for core liver biopsies in potential living related liver transplant donors: preliminary results. J Vasc Interv Radiol. 2006 August;17(8):1307-12.

Jain A, Orloff M, Kashyap R, Lansing K, Betts R, Mohanka R, Menegus M, Ryan C, Bozorgzadeh A. Does valganciclovir hydrochloride (valcyte) provide effective prophylaxis against cytomegalovirus infection in liver transplant recipients? Transplant Proc. 2005 September;37(7):3182-6.

Baichi MM, Arifuddin RM, Mantry PS, Bozorgzadeh A. Ryan C. Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis. Transplantation. 2005 December 15;80(11):1630-2.

Khorana AA, Hu YC, Ryan CK, Komorowski RA, Hostetter G, Ahrendt SA. Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer. J Gastrointest Surg. 2005 September-October;9(7):903-11.

Bozorgzadeh A, Jain A, Ryan C, Ornt D, Zand M, Mantry P, Lansing K, Orloff M. Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus. Transplantation. 2004 April 15;77(7):1066-70.

Shunyakov L, Ryan CK, Sahasrabudhe DM, Khorana AA. The influence of host response on colorectal cancer prognosis. Clin Colorectal Cancer. 2004 May;4(1):38-45. Review.

Helpful Links

• Pathology Department Faculty List
• Areas of Excellence - Anatomic Pathology
• Areas of Excellence - Clinical Pathology
• Pathology Ph.D. Program Faculty

Pathology & Laboratory Medicine Sites

Pathology and Laboratory Medicine URMC Clinical Laboratories URMC Central Laboratory Research and Academics Residency Program Graduate Studies