Clinical interests include genitourinary pathology, gastrointestinal pathology, Cytopathology (endoscopic ultrasound-guided fine needle aspiration biopsy), and the rapid diagnosis of superficial palpable lesions by fine needle aspiration biopsy.

Qualifications

M.D., University of the East - Ramon Magsaysay Memorial Medical Center 1990
Intern, General Medicine, St. Luke's Medical Center, Quezon City, Philippines 1990-91
Resident, Pathology, University of the Philippines, Manila 1992-93
Resident in Pathology (AP/CP), The Brooklyn Hospital Center 1994-98
Fellow, Surgical Pathology, New York University Medical Center 1998-99
Fellow, Cytopathology, New York University Medical Center 1999-2000
Fellow, Genitourinary Pathology, University of Rochester Medical Center 2003-04
Board Certified, American Board of Pathology (AP/CP)

Research Overview

I have three major areas of research interests: Genitourinary (GU) Pathology, Tissue Microarrays (TMA), and Fine Needle Aspiration Biopsy (FNA).

During my GU pathology fellowship, I became fascinated by the role of neuroendocrine cells in the benign and neoplastic prostate (see Neuroendocrine website). Subsequently, I decided to study the pathogenesis and characterization of a rare and aggressive form of prostate cancer called small cell carcinoma of the prostate (see Publications below).

At the same time, I was introduced to the construction and use of TMAs for translational and clinical research. Our GU Pathology section has constructed a prostate progression TMA and a kidney tumor prevalence TMA, which have proved very useful in translational research at our institution. We are currently constructing prognostic TMAs for both the prostate and esophagus.

As a cytopathologist, I am involved with improving the efficiency of both superficial palpable lesions and endoscopic ultrasound-guided FNAs of pancreatico-duodenal lesions through the use of novel site-specific antibody panels. Working closely with the Immunocytochemistry laboratory, I am currently evaluating various antibody panels for pancreatic carcinoma from material obtained by endoscopic ultrasound-guided FNA.

Publications

Wu C, Zhang L, Bourne PA, Reeder JE, di Sant'agnese PA, Yao JL, Na Y, Huang J. Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. Prostate. 2006 May 1; [Epub ahead of print]

Bao BY, Yao J, Lee YF. 1{alpha}, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis. 2006 Apr 19; [Epub ahead of print]

Ni J, Wen X, Yao J, Chang HC, Yin Y, Zhang M, Xie S, Chen M, Simons B, Chang P, di Sant'Agnese A, Messing EM, Yeh S. Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. Cancer Res. 2005 Nov 1;65(21):9807-16.

Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant'Agnese PA, Reeder JE. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol. 2005 Jun;166(6):1807-15.

Li R, Ni J, Bourne PA, Yeh S, Yao J, di Sant'Agnese PA, Huang J. Cell culture block array for immunocytochemical study of protein expression in cultured cells. Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):85-90.

Li R, Yao JL, Bourne PA, di Sant'Agnese PA, Huang J. Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma. Arch Pathol Lab Med. 2004 Dec;128(12):1412-7.

Yao JL, Bourne PA, Yang Q, Lei J, di Sant'Agnese PA, Huang J. Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2004 Jul; 128(7): 785-7.

Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, Tsui W, Ohta H and Nakanuma Y. Hepatic 'stem cell' malignancies in adults: four cases. Histopathology. 2003 Sep; 43(3): 263-71.

Moreira AL, Yao J, Waisman J and Cangiarella JF. Metastatic "Borderline" Papillary Ovarian Tumor in an Intramammary Lymph Node. The Breast Journal. 2002 May; 8(5) 309-10.

Yao JL, Cangiarella JF, Cohen J-M, and Chhieng D. Fine Needle Aspiration Biopsy of Peripheral T-Cell Lymphomas: A Cytologic and Immunophenotypic Study of 33 Cases. Cancer Cytopathology. 2001 Apr 25; 93(2): 151-9.

 

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