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Ming Qi, Ph.D.

Research Associate Professor
of Pathology and Laboratory Medicine
in the Center for Cardiovascular Research

Blood Transfusion Immunology

Functional Genomics Center
211 Bailey Road, Suite 1
W. Henrietta, NY 14586
Tel: (585) 276-9995
Fax: (585) 427-9334

Ming_Qi@urmc.rochester.edu

Dr. Qi divides his time between Rochester and his position as Professor and Director of the Center for Genetic and Genomic Medicine at Zhejiang University School of Medicine. He is also a Visiting Professor in the Human Genome Center, a PI in the Bejing Genomics Institute at the Chinese Academy of Sciences, and a Visiting Associate Geneticist/Consultant and Acting Director of Lab Molecular Medicine at the Harvard Medical School-Partners Health Center for Genetics & Genomics. For the past three years, he has organized an October symposium and short course in Medical and Laboratory Applications of Genetics and Genomics in Hangzhou, China.

Qualifications

Ph.D., Molecular Biology, University of Pittsburgh 1991
Fellow, Molecular Biology, Univ. of Washington (Pharmacology) 1991-94
Fellow, Medical Genetics, Univ. of Washington (Medicine & Pathology) 1994-98
Board Certified, American Board of Medical Genetics, 1999

Professional Activities

Board Member, Association of Chinese Geneticists in America 2005-
Board Member, Chinese Medical Association, Division of Medical Genetics 2007-
Board Member, Chinese Birth Defect Prevention Association 2007-
Program Committee, Second Workshop on Clinical and Laboratory Genomic and Genetic Standards, sponsored by the DIA and FDA, Dec 13-14, Bethesda, MD, USA

Research Overview

Molecular pathology of genetic diseases seeks to explain why a given genetic change should result in a particular clinical phenotype. With its rapid progress, the knowledge in the field not only forms the cutting edge of biomedical research, but at the same time it has immediate application to the diagnosis of more and more diseases, and has great potential for the management of those diseases. Clinical symptoms are often the end result of a long chain of causation and complicate genetic interaction. The goals of the research in this laboratory, collaborated with multiple laboratories inside and outside the University, are to developing new tests for molecular diagnosis, and identify new genes responsible for bone and cardiovascular genetic diseases. Approaches of gene functional cloning, positional candidate gene cloning, and gene knock-out/in have been used in these studies.

Publications

Moss AJ, Shimizu W, Wilde AA, Towbin JA, Zareba W, Robinson JL, Qi M, Vincent GM, Ackerman MJ, Kaufman ES, Hofman N, Seth R, Kamakura S, Miyamoto Y, Goldenberg I, Andrews ML, McNitt S. Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation. 2007 May 15;115(19):2481-9.

Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome and pregnancy. J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8.

Sauer AJ, Moss AJ, McNitt S, Peterson DR, Zareba W, Robinson JL, Qi M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome in adults. J Am Coll Cardiol. 2007 Jan 23;49(3):329-37.

Hobbs JB, Peterson DR, Moss AJ, McNitt S, Zareba W, Goldenberg I, Qi M, Robinson JL, Sauer AJ, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Towbin JA, Vincent GM, Zhang L. Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA. 2006 Sep 13;296(10):1249-54.

Goldenberg I, Moss AJ, Zareba W, McNitt S, Robinson JL, Qi M, Towbin JA, Ackerman MJ, Murphy L. Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome. J Cardiovasc Electrophysiol. 2006 Nov;17(11):1161-8.

Moss AJ, Windle JR, Hall WJ, Zareba W, Robinson JL, McNitt S, Severski P, Rosero S, Daubert JP, Qi M, Cieciorka M, Manalan AS. Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial. Ann Noninvasive Electrocardiol. 2005 Oct;10(4 Suppl):59-66.

Zareba W, Moss AJ, Sheu G, Kaufman ES, Priori S, Vincent GM, Towbin JA, Benhorin J, Schwartz PJ, Napolitano C, Hall WJ, Keating MT, Qi M, Robinson JL, Andrews ML; International LQTS Registry, University of Rochester, Rochester, New York. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. J Cardiovasc Electrophysiol. 2003 Nov;14(11):1149-53.

Ning L, Moss A, Zareba W, Robinson J, Rosero S, Ryan D, Qi M. Denaturing high-performance liquid chromatography quickly and reliably detects cardiac ion channel mutations in long QT syndrome. Genet Test. 2003 Fall;7(3):249-53.

Ning L, Moss AJ, Zareba W, Robinson J, Rosero S, Ryan D, Qi M. Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome). Ann Noninvasive Electrocardiol. 2003 Jul;8(3):246-50.

Brandon EP, Logue SF, Adams MR, Qi M, Sullivan SP, Matsumoto AM, Dorsa DM, Wehner JM, McKnight GS, Idzerda RL. Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice. J Neurosci. 1998 May 15;18(10):3639-49.

Qi M, Byers PH. Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome. Hum Mol Genet. 1998 Mar;7(3):465-9.

Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, Nathanson NM. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13311-6.

Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, Costa T, Pierpont ME, Rand EB, Piccoli DA, Hood L, Spinner NB. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet. 1997 Jul;16(3):243-51.

Qi M, Zhuo M, Skalhegg BS, Brandon EP, Kandel ER, McKnight GS, Idzerda RL. Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1571-6.