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Zhenhong Qu, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

Surgical Pathology, Hepatobiliary Pathology,
Immunocytochemistry, Pathology Informatics

URMC Labs
601 Elmwood Ave., Rm G-5264H
Rochester, NY 14642-8626
Tel: (585) 275-7562
Fax: (585) 273-3637

Zhenhong_Qu@urmc.rochester.edu

Dr. Qu plays an active role in the liver transplant pathology program. He serves as the surgical pathology liaison to the Clinical Laboratories Systems Support group, and is offering hands-on experience for students and residents in the development of web-based pathology tools. See his pathology informatics pages for examples.

Qualifications

M.D., Tongji Medical University, China 1982
Research/Pathology Fellow, Universitys of Essen and Bochum, Germany 1985-88
Ph.D., Cell and Molecular Biology, The Oregon Health Sciences University 1995
Postdoctoral Fellow, Rheumatology, The Oregon Health Sciences Univ., 1995-97
Pathology Resident, Beth Israel-Deaconess Medical Center 1997-2000
Fellow, Surgical Pathology, Hospital of the University of Pennsylvania 2000-2001
Board Certified, American Board of Pathology (AP) 2003

Research Overview

Current research activities include:

  • Molecular characterization of cell markers for diagnostic pathology
  • Expert system for morphologic diagnosis of common neoplasms
  • Computer-assisted surgical pathology signout
  • Combined text hyperlink and touch screen technology for information access in biohazardous environment
  • Highly flexible, cost-effective and user friendly imaging management system for anatomic pathology
  • On-line image database for anatomic pathology

Publications

List of Full-Length Articles and Book Chapter:

Qu Z. and Zhao X. Z.:Oncogenes and Tumorigenesis. In: Clinical Pathophysiology. Ed. Li Z. J.,Lu X., and Zhao X. Z., Guandong Acdemic Press, P.R.China, Volume I, page 412 - 436, 1990. (ISBN: 7-5359-0269-3/R.51)

Qu Z., Hernandez-Garcia C., O'Rourke L. M., Planck S. R , Hart C. E. and Rosenbaum J. T.: Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia: results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum. 37:212-220, 1994.

Qu Z., Dang T., Picou M. A., Angell E., Hart C. E., Planck S. R. and Rosenbaum J. T.: Immunolocalization of basic fibroblast growth factor and platelet-derived growth factor-A during adjuvant arthritis in the Lewis rat. Am. J. Pathol. 145: 1127 - 1139, 1994.

Qu Z., Liebler J. M., Powers M. R., Galey T., Huang X.-Na., Ansel J. C., Butterfield J. H. , Planck S. R. and Rosenbaum J. T.: Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am. J. Pathol. 147: 564 - 573, 1995.

Qu Z.Qu Z. , Huang X.-Na., Andresevic J , Ahmadi P, Planck S. R , Hart C. E. and Rosenbaum J. T.: Expression of basic fibroblast growth factor in synovial tissue from patients with rheumatoid arthritis and degenerative joint disease. Lab. Invest. 73: 339 -346, 1995.

Ahmadi P., Qu Z., Kayton R. J., D Anderson, Spangler W. D., Planck S. R. and Rosenbaum J. T.: Enzymatic Digestion is Also an Effective Antigenicity-Restoring Method for Immunohistochemistry at the Electron Microscopic (EM) Level. Proceedings in Microsopy &. Microanalysis. pp. 42-43, 1996.

Powers M. R., Qu Z., O'Brien B., Wilson D. J., Thompson J. E., and Rosenbaum J. T. : Immunolocalization of bFGF in Pterygia -- association with mast cells. Cornea 16:545-549, 1997.

Liebler J. M., Picou M. A., Qu Z., Powers M. R. and Rosenbaum J. T.: Altered immunohistochemical localization of basic fibroblast growth factor after bleomycin-induced lung injury. Growth Factor 14:25-38, 1997.

Qu Z., Huang X.-Na., Ahmadi P., Stenberg P., Liebler J. M., Le A-C., Planck S. R. and Rosenbaum J. T.: Expression of basic fibroblast growth factor (bFGF) by murine mast cells -- regulation by transforming growth factor beta, tumor necrosis factor alpha, and stem cell factor. Int. Arch. Allergy Immunol. 115:47-54, 1998.

Qu Z., Kayton R., Ahmadi P., Liebler J. M., Powers M. R. Planck S. R., and Rosenbaum J. T.: Ultra-structural Immunolocolization of Basic Fibroblast Growth Factor in Mast Cell Secretory Granules -- Morphological Evidence for bFGF release through degranulation. J. Histochem. Cytochem. 46:1119-1128, 1998.

Liebler J. M., Qu Z., Buckner B., Powers M. R. and Rosenbaum J. T.: Fibroproliferation and mast cells in the acute respiratory distress syndrome. Thorax 53:823-829, 1998.

Powers M. R., Qu Z., LaGesse P., Liebler J. M., Wall M. A., and Rosenbaum J. T. : Expression of basic fibroblast growth factor in nasal polyps. Ann. Otol. Rhinol. &. Laryngol. 107:891-897, 1998.

Lemos L. B., Qu Z., Laucirica R., and Fred H. L.: Hyperinfection Syndrome in Strongyloidiasis: Report of Two Cases. Ann. Diagn. Pathol. 7(2):87-94, 2003.

Lemos L. B., Qu Z., and Papasozomenos, S.: Pseudoneoplastic Proliferation of Histiocytes with Paclitaxel-induced Ultrastructural Changes in a Mastectomy Specimen. Ann Diagn Pathol. 8(5):299-304, 2004.

Pereira, K. D., Bennett, K. M., Elkins, T. P., and Qu Z.: Ameloblastic Fibroma of the Maxillary Sinus. Int. J. Pediatr. Otorhinolaryngol. 68(11):1473-1477, 2004.

Garg K., Lee P., Ro JY., Qu Z., Troncoso P., and Ayala A.G.: Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases. Ann Diagn Pathol. 9(1):11-5, 2005.

Qu Z., Immunohistological Detection of Growth Factors and Cytokines in Tissue Mast Cells. In: Methods in Molecular Biology -- Mast Cells Methods and Protocols. Edited by Guha Krishnaswamy &. David S. Chi. Humana Press Inc. 2005.

Qu Z., Ghorbani R. and Robert Hunter: A Computerized Procedure Manual with Touch-on-Screen Navigation for Anatomic Pathology. 2005 (completed).

Qu Z., Feldman M., Nguyen A., Ivan D. and Hunter R.: A Powerful, Easy-to-Use, and Cost-Effective Image Acquisition and Management System for Surgical Pathology. 2005 (completed).

List of Reports or Manuscripts in Preparation

Qu Z., Chang K.G. and Kuruvilla S.: A Simple Modification of CAP Checklist Minimizes Extensive Editing and Reduces Clerical Error in Pathology Tumor Reporting. (in preparation).

Qu Z., Abadeer R., Kundu U., and Wanger A.: Strongyloides Colitis Mimics Ulcerative Colitis: A Case Report and Literature Review with Focus on the Morphological Differential Diagnosis.

List of Abstracts and Meeting Presentations

Qu Z.,Echoff A., and Mühler K.-M.: Localization of fibronectin in human lung carcinomas: Poster and presentation at the annual "Pathologentreffen der Rheinprovinz" June, 1988, Universität Düsseldorf, D-4000 Düsseldorf, West Germany.

Qu Z., Planck S. R , Hart C. E. and Rosenbaum J. T.: Localization of platelet-derived growth factor (PDGF) isoforms and PDGF receptor in synovial tissues from patients with rheumatoid arthritis (RA) and degenerated joint disease (DJD). Arthritis. Rheum. 33 (9) (supplement): S42, 1990.

Hernández-García C, Qu Z., Planck P. R., Rosenbaum J. R.: Detección del producto del anti-oncogén p53 en membrana sinovial de AR. XIX Congreso de la Sociedad Española de Reumatología. San Sebastián. 1992. (Detection of the anti-oncogen p53 product in synovial membrane of RA. 19th meeting of the Spanish Society of Rheumatology.) (Oral presentation)

Picou MA., Liebler J. M., Qu Z., Powers M. R. and Rosenbaum J. T.: Immunohistochemical localization of basic fibroblast growth factor in bleomycin-induced lung injury. Am. Rev. Resp. Dis. 147: A85, 1993.

Gregory K. W., Buckley L. A., Haw T E., Grunkemeier J. M., Chasleney E. A., Qu Z., Tuke-Bahiman D.,Fahrenbach H. and Block P. C.: Photochemotherapy of intimal hyperplasia using psoralen activated by ultra-violet light in a porcine model. Circulation 88 (4) pt.4: I-82, 1993.

Powers M. R., Qu Z., Liebler J. M., LaGesse P., Wall. M. A. and Rosenbaum J. T.: Immunohistochemical localization of basic fibroblast growth factor and proliferating cell nuclear antigen in nasal polyp tissue. Am. J. Resp. Crit. Care Med. 149 (4): A707, 1994.

Liebler. J. M., Qu Z., Powers M. A., Picou L., O'rourke L., Galey T., and Rosenbaum J. T.: Immunohistochemical localization of basice fibroblast growth factor and tryptase in human fibrotic lung tissue. Am. J. Resp. Crit. Care Med. 149 (4): A379, 1994.

Qu Z., Angell E., Sauser D., Planck S. R. and Rosenbaum J. T.: Basic fibroblast growth factor improves adjuvant arthritis, while a growth factor antagonist worsens the disease. Arthritis Rheum. Arthritis Rheum. 37 (suppl): S399, 1994.

Qu Z., Lea A.-C., Ahmadi P., Liebler J. M., Ansel J. C., Planck S. R. and Rosenbaum J. T.: Murine mast cells synthesize and release basic fibroblast growth factor (FGF-2). ASCB (Special Poster Session): H91, 1994.

Liebler J. M., Qu Z., O'Rurke L., Powers M. R., Peters J. I., Coalson J. J. and Rosenbaum J. T.: Increased number of mast cells correlate with fibroproliferation in the adult resporatory distress syndrome (ARDS). AJRCCM 151: A765, 1995.

Qu Z., Branham V., Ahmadi P., Planck S. R. and Rosenbaum J. T.: Immunolocalizarion implicates fibroblast growth factor receptor-2 in synovial hyperplasia in patients with rheumatoid arthritis (RA). Arthritis Rheum. 38 (9, supplement): S355, 1995.

Liebler J. M., Qu Z., Powers M. R., Picou M., Ahmadi P. and Rosenbaum T. J.: Intensity of immunolocalization of basic fibroblast growth factor (bFGF) corresponds to increased cell proliferation in bleomycin-induced lung injury. 1996. (submitted to ATS)

Liebler J. M., Qu Z., O'Brian B, Powers M. R., and Rosenbaum T. J.: Fibroblast growth factor receptor 1 (FGFR-1) and 2 (FGFR-2) in human and experimental pulmonary fibrosis. AJRCCM 153: A311, 1996.

Ahmadi P., Qu Z., Powers M. R., Kayton R. J., Morrison L., Planck S. R. and Rosenbaum J. T.: Light and Electron Microscopic Immunolocalization of bFGF in Eosinophils in Chronic Inflammatory Tissues (Abstract). FASEB 10(6):A1478, 1996.

Qu Z., Ahmadi P., Stenberg P., Kayton R. J., Planck S. R. and Rosenbaum J. T.: Ultrastructural Immunolocalization of Basic Fibroblast Growth Factor-Like Molecules in Cytoplasmic Granules of Mast Cells in Inflamed Tissue (Abstract). FASEB 10(6):A1263, 1996.

Rosenbaum J. T., Qu Z., Spangler W. D. and Planck S. R.: Immunolocalization of Fibroblast Growth Factor Receptor-1 and -2 in Joint Tissue from Rats with Adjvant Polyarthritis (Abstract). FASEB 10(6):A2757, 1996.

Martin T.M., Qu Z., Huang X. N., Planck S.R., Edwards A., and Rosenbaum J. T.: Exclusion of the IL-4 receptor as the Blau syndrome gene. Invest. Ophthalmol. Vis. Sci 39:S362 1998.

Liebler J. M., Powers M. R., J. Eubanks J., Qu Z. and Rosenbaum J. T.: Immunolocalization of Interleukin 10 (IL-10) in the Acute Respiratory Distress Syndrome (ARDS) and Idiopathic Pulmonary fibrosis (IPF). Am J. Resp. &. Crit Care Med. 159:A108, 1999.

Ivan D., Nguyen A., Lemos L. and Qu Z.: A Powerful, Easy-to-Use, and Cost-Effective Image Acquisition and Management System for Surgical Pathology. ASCP Meeting Abstract 2002

Jiang L., Ninan S., Kott M. and Qu Z.: A Flexible, User Friendly, Web-Based Test Order Database for Surgical Pathology. ASCP Meeting Abstract 2002

Zhang H., Ninan S. and Qu Z.: Computer-Assisted Routine Sign-out in Surgical Pathology: A new tool to enhance independence and improve performance of trainees. ASCP Meeting Abstract 2002.

Hannah C., Ghorbani R. and Qu Z.: A Computerized Surgical Pathology Procedure Manual with Touch-on-Screen Navigation. ASCP Meeting Abstract 2002

Gu Y., CD Hannah C.D., Chughtai O.R., Qu Z.: A Computer-Assisted Diagnostic System for Inflammatory Skin Disease. Abstract [1474], ASCAP Annual meeting, 2003 March.

Kuruvilla S., Qu Z., and Chang K.G.: A Simple Modification of CAP Checklist Minimizes Extensive Editing and Reduces Clerical Error in Pathology Tumor Reporting. Mod Pathol. 18 (suppl. 1):323A (Abstract 1503), 2005.

Ostler D.A., Ninan S., and Qu Z.: Computerized Diagnostic Consultation System for Hepatobiliary Pathology. Mod Pathol. 18 (suppl. 1):332A (Abstract 1544), 2005.