Investigators and Projects
This is a list of projects that departmental investigators
are working on, or that they have completed. They're grouped
to show intra- and interdepartmental areas of concentration.
BONE DISEASE
Brendan F. Boyce, M.D
| Studies of the fate of the osteoclast |
| Rank/NF-KappaB signaling in chondrogenesis |
| Effects of potential anabolic agents on bone formation
in vivo |
| Effects of SRC inhibitors on bone |
J.
Edward Puzas, Ph.D. (primary
appointment in Orthopaedics)
| The effect of lead on skeletal remodeling in vitro |
| The skeleton as a site for prostate cancer metastasis |
| Lead toxicity in the skeleton and its role in osteoporosis |
Ming Qi, Ph.D.
| Knock-in mouse model for osteogenesis imperfecta and treatment effects
of bisphosphonate |
| Mouse models of osteogenesis imperfecta |
Lianping Xing, M.D., Ph.D.
| Role of TNF alpha in osteoclast-medited bone loss |
| Proteasomal regulation of TNF-mediated local bone loss |
BREAST CANCER/OVARIAN CANCER
Chawnshang Chang, Ph.D.
| New PTEN signal pathway in breast cancer |
Linda Schiffhauer, M.D.
| Cost-effectiveness of treatments for DCIS |
| High resolution cone beam volume CT for breast imaging |
Ping Tang, M.D., Ph.D.
| ID of simple molecular markers/patterns that predict a subgroup of DCIS
with high risk of progression to IDC |
Nancy Wang, Ph.D.
| The role of Thy-1 in ovarian tumor suppressor |
Shu-Yuan Yeh, Ph.D. (primary appointment in
Urology)
| From BRCA1 tumor suppressor to androgen receptor: New signal
pathway in breast cancer |
| MAP kinase signal of AR and AR coregulators |
CARDIOVASCULAR DISEASE
(see also Lipoprotein Metabolism below)
Daniel H. Ryan, M.D.
| Correlation of factor V Leiden and P1A2 genotype with age
of onset and severity of myocardial infarction |
| Thrombogenic factors and recurrent coronary events |
Peter J. Sims, M.D., Ph.D
| Molecular mechanisms of inflammation and thrombosis |
| Role of PL scramblase in interferon action |
Therese Wiedmer, Ph.D.
| Molecular mechanisms of inflammation and thrombosis |
| Role of PL scramblase in interferon action |
Haodong
Xu, M.D., Ph.D.
| Role of Modulation of Voltage-Gated K+ Channels
by Kinases in Cardiac Dysrhythmias |
DIABETES/OBESITY
Robert A. Mooney, Ph.D.
| Insulin action and phosphotyrosine phosphatases |
| Role of PTPase LAR in EGF receptor in the mammary gland |
| SOCS proteins - inhibitors of hepatic insulin receptors |
| Role of macrophages in obesity dependent insulin resistance |
Peter J. Sims, M.D., Ph.D.
| Role of PLSCR3 in adipogenesis and adipose lipid storage |
| PLSCR3-/- mice and metabolic syndrome |
| Regulation of growth factor signaling by PLSCRs |
Therese Wiedmer, Ph.D.
| Role of PLSCR3 in adipogenesis and adipose lipid storage |
| PLSCR3-/- mice and metabolic syndrome |
| Regulation of growth factor signaling by PLSCRs |
GASTROINTESTINAL/TRANSPLANT PATHOLOGY
Charlotte K. Ryan, M.D.
| Amino acid transport after small bowel resection |
Wei-Ping Zheng, Ph.D..
| Role of Foxp3 in inflammatory bowel disease |
GENITOURINARY CANCER
Chawnshang Chang, Ph.D.
| AR-associated proteins in prostate carcinogenesis |
| Molecular epidemiology of AR expression in prostate |
| T vs DHT-specific antiandrogens in prostate cancer |
| Analysis of the androgen and prostate cancer tissue |
| TR2 and TR3 orphan receptors in prostate cancer |
| TR4 orphan receptor in testis |
| Suppression of androgen receptor transactivation by Akt
kinase |
| Suppression of androgen receptor by PTEN |
| Induction of AR transactivation by DHT & E2 |
| Single and double knockout of TR2 and TR4 receptors |
| AR in prostate cancer and bone |
| Knockout AR in prostate |
P. Anthony di Sant'Agnese, M.D.
| MAP kinase signal of AR and AR coregulators (Co-PI) |
Jiaoti Huang, M.D.
| Neuroendocrine differentiation and IL-8 signaling in prostate
cancer |
| Function of PTP1B in NE differentiation of prostate cancer |
| HCA expression in epithelial malignancies and prostatic
carcinoma |
Jay E. Reeder, Ph.D.
| Molecular pathology of recurrent bladder cancer |
| Function of DBCCR1 in bladder cancer |
| Temporal control of receptor tyronsine kinase activity in
the mouse urothelium |
| Interstitial cystitis clinical trials (Co-PI) |
| Inducible gene expression in mouse urothelium |
HEMATOLOGY/ONCOLOGY
Daniel H. Ryan, M.D.
| B lineage development of human hematopoietic progenitors |
Peter J. Sims, M.D., Ph.D.
| PLSCR1 in granulocyte maturation and function |
| PLSCR1 in leukemia |
| Nuclear PLSCR in differentiation and apoptosis |
Therese Wiedmer, Ph.D.
| PLSCR1 in granulocyte maturation and function |
| PLSCR1 in leukemia |
| Nuclear PLSCR in differentiation and apoptosis |
IMMUNOLOGICAL DISORDERS
Chawnshang Chang, Ph.D.
| AR in B cell development and function |
Myra Coppage, Ph.D.
| Characterization of HLA-specific B-cells isolated using
HLA tetramers |
LIPOPROTEIN METABOLISM
James P. Corsetti, M.D.,
Ph.D.
Charles E. Sparks, M.D.
| Hepatic metabolism of apolipoprotein B |
| Thrombogenic factors and recurrent coronary events (Co-PI) |
Janet D. Sparks, Ph.D.
| Insulin, P1 3-kinase and apolipoprotein B biogenesis |
| Relationship of Apo B and BHMT: nutrition and physiology |
| Insulin regulated hepatic APO B lipoprotein biogenesis |
| The role of fatty acids in VLDL production in diabetes |
NEURODEGENERATIVE DISEASES
Linda M. Callahan, Ph.D.
| Mechanisms of synapse loss in AD neurons |
James M. Powers, M.D.
| Alzheimer's disease center grant - Neuropathology section |
| HHV6 as a co-agent in MS and demyelination |
TOXICOLOGY
Tai C. Kwong, Ph.D.
| Placenta: Ethanol and premature rupture of the membrane |
| Oxidative damage and premature rupture of the membrane |
TRANSFUSION MEDICINE
Neil Blumberg, M.D.
| Morbidity and mortality in AML: the role of blood transfusion |
Scott A. Kirkley, M.D.
Sherry Spinelli, Ph.D.
| The PPARgamma pathway and storage of platelets for transfusion |
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