Investigators and Projects
This is a list of projects that departmental investigators
are working on, or that they have completed. They're grouped
to show intra- and interdepartmental areas of concentration.
BONE DISEASE
Brendan F. Boyce, M.D
| Effects of compound KX2-391 on osteolytic bone metastases in vivo and on osteoclasts and osteoblasts in vitro |
| Studies of the fate of the osteoclast |
| Effects of acid on bone (Bushinsky, Nephrology) |
| Hematopoietic-osteoblastic interactions (Calvi, Medicine) |
| Canonical Wnt signaling controls mesenchymal stem cell differentiation (Chen, Orthopaedics) |
| Translating molecular signal pathways to orthopaedic trauma care (Rosier, Orthopaedics) |
| Rank/NF-Kappa B signaling in chondrogenesis |
| Effects of potential anabolic agents on bone formation
in vivo |
| Effects of SRC inhibitors on bone |
J.
Edward Puzas, Ph.D. (primary
appointment in Orthopaedics)
| The effect of lead on skeletal remodeling in vitro |
| The skeleton as a site for prostate cancer metastasis |
| Lead toxicity in the skeleton and its role in osteoporosis |
Ming Qi, Ph.D.
| Knock-in mouse model for osteogenesis imperfecta and treatment effects
of bisphosphonate |
| Mouse models of osteogenesis imperfecta |
Lianping Xing, M.D., Ph.D.
| Role of TNF alpha in osteoclast-medited bone loss |
| Proteasomal regulation of TNF-mediated local bone loss |
BREAST CANCER/OVARIAN CANCER
Chawnshang Chang, Ph.D.
| New PTEN signal pathway in breast cancer |
David Hicks, M.D.
| Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis (McCann, Roswell Park)
|
Linda Schiffhauer, M.D.
| Cost-effectiveness of treatments for DCIS |
| High resolution cone beam volume CT for breast imaging (Ning, Imaging Sciences) |
Ping Tang, M.D., Ph.D.
| ID of simple molecular markers/patterns that predict a subgroup of DCIS
with high risk of progression to IDC |
| Predicting bone metastasis of breast cancer |
Nancy Wang, Ph.D.
| The role of Thy-1 in ovarian tumor suppressor |
Shu-Yuan Yeh, Ph.D. (primary appointment in
Urology)
| From BRCA1 tumor suppressor to androgen receptor: New signal
pathway in breast cancer |
| MAP kinase signal of AR and AR coregulators |
CARDIOVASCULAR DISEASE
(see also Lipoprotein Metabolism below)
Faqian Li, M.D., Ph.D.
| Beta-catenin signaling and cardiac chamber remodeling during late heart development |
Ming Qi, Ph.D.
| Long QT syndrome: population, genetic and cardiac studies (Moss, Cardiology) |
Daniel H. Ryan, M.D.
| Correlation of factor V Leiden and P1A2 genotype with age
of onset and severity of myocardial infarction |
| Thrombogenic factors and recurrent coronary events (Moss, Cardiology) |
Peter J. Sims, M.D., Ph.D
| Molecular mechanisms of inflammation and thrombosis |
| Role of PL scramblase in interferon action |
Therese Wiedmer, Ph.D.
| Molecular mechanisms of inflammation and thrombosis |
| Role of PL scramblase in interferon action |
Haodong
Xu, M.D., Ph.D.
| Role of Modulation of Voltage-Gated K+ Channels
by Kinases in Cardiac Dysrhythmias |
DIABETES/OBESITY
Robert A. Mooney, Ph.D.
| Insulin action and phosphotyrosine phosphatases |
| Role of PTPase LAR in EGF receptor in the mammary gland |
| SOCS proteins - inhibitors of hepatic insulin receptors |
| Role of macrophages in obesity dependent insulin resistance |
Peter J. Sims, M.D., Ph.D.
| Role of PLSCR3 in adipogenesis and adipose lipid storage |
| PLSCR3-/- mice and metabolic syndrome |
| Regulation of growth factor signaling by PLSCRs |
Therese Wiedmer, Ph.D.
| Role of PLSCR3 in adipogenesis and adipose lipid storage |
| PLSCR3-/- mice and metabolic syndrome |
| Regulation of growth factor signaling by PLSCRs |
GASTROINTESTINAL/TRANSPLANT PATHOLOGY
Chawnshang Chang, Ph.D.
| Androgen receptor role in liver cancer incidence and progression |
Charlotte K. Ryan, M.D.
| Biomarkers for esophageal cancer progression and prognosis (Godfrey, Surgery) |
| Amino acid transport after small bowel resection (Sax, Surgery) |
Zhongren Zhou, M.D., Ph.D.
| Epidemiology of Barrett's esophagus: goblet cell or no goblet cell? |
GENITOURINARY CANCER
Chawnshang Chang, Ph.D.
| New mice models for studies of androgen receptor (AR) in prostate cancer |
| Loss of androgen receptor promotes metastatic prostate cancer (with Yeh, Urology) |
| AR-associated proteins in prostate carcinogenesis |
| Molecular epidemiology of AR expression in prostate |
| T vs DHT-specific antiandrogens in prostate cancer |
| Analysis of the androgen and prostate cancer tissue |
| TR2 and TR3 orphan receptors in prostate cancer |
| TR4 orphan receptor in testis |
| Suppression of androgen receptor transactivation by Akt
kinase |
| Suppression of androgen receptor by PTEN |
| Induction of AR transactivation by DHT & E2 |
| Single and double knockout of TR2 and TR4 receptors |
| AR in prostate cancer and bone |
| Knockout AR in prostate |
P. Anthony di Sant'Agnese, M.D.
| MAP kinase signal of AR and AR coregulators (Yeh, Urology) |
Tai C. Kwong, Ph.D.
| Prospective study of chronic kidney disease in children (Schwarz, Pediatrics) |
Hiroshi Miyamoto, M.D., Ph.D.
| Dehydroepiandrosterone derivatives as potent antiandrogens with marginal agonist activity |
Jorge Yao, M.D.
| 3D sonoelastography imaging for prostate cancer (Rubens, Imaging Sciences) |
| 3TR4 orphan receptor, a longevity assurance gene, in prostate carcinogenesis |
HEMATOLOGY/ONCOLOGY
W. Richard Burack, M.D., Ph.D.
| SPORE in lymphoma (R Fisher, Cancer Center) |
| A comprehensive investigation of viral-induced lymphomagenesis (S Fisher, Public Health Sciences) |
Archibald Perkins, M.D., Ph.D.
| Mechanisms of EVI1-induced leukemogenesis |
| Leukemic transformation by the SML 1/MDS 1 EVI 1 protein |
| The role of unfolded protein response in paroxysmal nocturnal hemoglobumia |
Daniel H. Ryan, M.D.
| B lineage development of human hematopoietic progenitors |
Peter J. Sims, M.D., Ph.D.
| PLSCR1 in granulocyte maturation and function |
| PLSCR1 in leukemia |
| Nuclear PLSCR in differentiation and apoptosis |
Therese Wiedmer, Ph.D.
| PLSCR1 in granulocyte maturation and function |
| PLSCR1 in leukemia |
| Nuclear PLSCR in differentiation and apoptosis |
IMMUNOLOGICAL DISORDERS
Chawnshang Chang, Ph.D.
| AR in B cell development and function |
Bruce_Goldman, M.D.
| Efficacy and mechanisms of proteosome inhibitor treatment in murine lupus (Anolik, Medicine) |
Myra Coppage, Ph.D.
| Characterization of HLA-specific B-cells isolated using
HLA tetramers |
| Improving cord blood stem cell engraftment through chemokine modulation |
LIPOPROTEIN METABOLISM
James P. Corsetti, M.D.,
Ph.D.
Charles E. Sparks, M.D.
| Hepatic metabolism of apolipoprotein B |
| Thrombogenic factors and recurrent coronary events (Moss, Cardiology) |
Janet D. Sparks, Ph.D.
| Hepatic steatosis modulation by Apo B gene transcription |
| Mechanism of IL6-dependent increases in hepatic triglyceride export in hepatic steatosis and insulin resistance |
| Insulin, P1 3-kinase and apolipoprotein B biogenesis |
| Relationship of Apo B and BHMT: nutrition and physiology |
| Insulin regulated hepatic APO B lipoprotein biogenesis |
| The role of fatty acids in VLDL production in diabetes |
NEURODEGENERATIVE DISEASES
Linda M. Callahan, Ph.D.
| Mechanisms of synapse loss in AD neurons |
Mahlon Johnson, M.D., Ph.D.
| Liponavir effects on human meningioma cell proliferation |
James M. Powers, M.D.
| Alzheimer's disease center grant - Neuropathology section |
| HHV6 as a co-agent in MS and demyelination |
TOXICOLOGY
Tai C. Kwong, Ph.D.
| Placenta: Ethanol and premature rupture of the membrane |
| Oxidative damage and premature rupture of the membrane |
TRANSFUSION MEDICINE
Neil Blumberg, M.D.
| Identification and significance of biologic mediators in red cell concentrates |
| Microparticles as messengers of communication between blood and vascular cells (Phipps, Environmental Health Sciences) |
| Blood transfusions: gender differences in utilization, predictors, and outcomes (Rogers, Univ of Michigan) |
| Morbidity and mortality in AML: the role of blood transfusion |
Scott A. Kirkley, M.D.
Majed Refaai, M.D.
| Beriplex P/N compared with plasma for rapid reversal of coagulopathy induced by coumarin derivatives in subjects with acute major bleeding |
Sherry Spinelli, Ph.D.
| Microparticles as messengers of communication between blood and vascular cells (Phipps, Environmental Health Sciences) |
| Identification and significance of biologic mediators in red cell concentrates |
| The PPARgamma pathway and storage of platelets for transfusion |
|
|
