Introduction: The Neuroendocrine Prostate
The Genitourinary Pathology Section (GUPS) at the URMC Department of Pathology and Laboratory Medicine has a special interest in the neuroendocrine prostate. It is our hypothesis that the neuroendocrine cell plays a critical role in both the normal functioning of the prostate and the progression of prostate cancer.
Dr. P. Anthony di Sant'Agnese has a long-standing research interest in the role of the prostatic neuroendocrine cell and neuroendocrine differentiation in prostate cancer. Past studies include seminal descriptive morphologic investigations as well as clinical-pathological correlative studies. His group was the first to describe several peptide hormone products of prostatic neuroendocrine cells as well as the ultrastructural morphology of neuroendocrine cell types. More recent research has focused on in vitro and in vivo investigations of regulatory mechanisms and phenotypic effects of prostatic neuroendocrine differentiation in cell lines and mouse models.
Dr. Jorge Yao became interested in the prostatic neuroendocrine cell during his GU Pathology fellowship at the URMC. He has participated in the construction of prostatic carcinoma tissue microarrays (TMA), including one containing neuroendocrine rich benign prostate and neuroendocrine differentiated prostate cancer. These TMAs facilitate the study of protein expression in a cost-effective manner. He is also interested in the pathogenesis and characterization of small cell carcinoma of the prostate, a rare and lethal form of neuroendocrine differentiated prostate cancer.
Dr. Hiroshi Miyamoto, who recently joined the team, has had a great interest in finding a clue to the mystery of the mechanism by which prostate cancer loses androgen-dependency, as a urologist (1988-1996), a basic researcher (1996-2005), and a pathologist (2005-present). Neuroendocrine differentiation in prostate cancer may contribute largely to its progression in an androgen-independent manner. In addition to clinical and translational studies on the neuroendocrine prostate, his basic research focuses on androgen receptor.
The members of GUPS have collaborated on these pages, and are also involved in the Clinical and Research operations of the URMC Immunocytochemistry Laboratory.