Jean M. Bidlack, Ph.D.

Jean M. Bidlack, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Books

2009
Bidlack, J.M., and Mathews, J.L.. "The Chemistry and Pharmacology of Mu Opioid Antagonists". Opiate Receptors and Antagonists: From Bench to Clinic. R. Dean, S.S. Negus, and E. Bilsky. Totowa, NJ: Humana Press, 2009. 83-97
2007
Bidlack, JM. "Review of Carleton K. Erickson. The Science of Addiction: From Neurobiology to Treatment.". Phi Kappa Phi Forum. New York: W.W. Norton & Company, 2007. 29

Journal Articles

Showing all 150 journal articles available.

2013 Apr 1
Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors." Bioorganic & medicinal chemistry letters. 2013 Apr 1; 23(7):2128-33. Epub 2013 Feb 08.
2013 Apr
Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. "Inhibition of G??-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward." Behavioural pharmacology. 2013 Apr; 24(2):144-52.
2012 Apr 26
Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, Bidlack JM. "Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors." Journal of medicinal chemistry.. 2012 Apr 26; 55(8):3878-90. Epub 2012 Apr 04.
2012 Feb
Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. "Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins." Future medicinal chemistry. 2012 Feb; 4(2):205-26.
2012 Jan
Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, Deaver DR. "Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats." Pharmacology, biochemistry, and behavior.. 2012 Jan; 100(3):530-7. Epub 2011 Oct 25.
2012
Wentland MP, Jo S, Gargano JM, Vanalstine MA, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC." Bioorganic & medicinal chemistry letters. 2012 22(24):7340-4. Epub 2012 Oct 27.
2011 Nov
Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. "Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments." Chemical biology & drug design. 2011 Nov; 78(5):749-56. Epub 2011 Sep 26.
2011 May 1
Zhang B, Zhang T, Sromek AW, Scrimale T, Bidlack JM, Neumeyer JL. "Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for ?, ?, and ? opioid receptors." Bioorganic & medicinal chemistry. 2011 May 1; 19(9):2808-16. Epub 2011 Mar 26.
2011 Apr
Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. "Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic." Pain.. 2011 Apr; 152(4):878-87.
2011 Mar 24
Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. "Aminothiazolomorphinans with mixed ? and ? opioid activity." Journal of medicinal chemistry.. 2011 Mar 24; 54(6):1903-13. Epub 2011 Feb 25.
2011 Mar
Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. "In vivo characterization of MMP-2200, a mixed ?/? opioid agonist, in mice." The Journal of pharmacology and experimental therapeutics.. 2011 Mar; 336(3):767-78. Epub 2010 Nov 30.
2011 Feb
Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL. "Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic." European journal of medicinal chemistry. 2011 Feb; 46(2):799-803. Epub 2010 Dec 08.
2010 Mar 1
Fulton BS, Knapp BL, Bidlack JM, Neumeyer JL. "Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors." Bioorganic & medicinal chemistry letters. 2010 Mar 1; 20(5):1507-9. Epub 2010 Jan 25.
2010 Mar
Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB. "Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling." Nature neuroscience.. 2010 Mar; 13(3):284-6. Epub 2010 Feb 07.
2010 Feb 17
Balboni G, Salvadori S, Trapella C, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Neumeyer JL. "Evolution of the Bifunctional Lead ? Agonist / ? Antagonist Containing the Dmt-Tic Opioid Pharmacophore." ACS chemical neuroscience. 2010 Feb 17; 1(2):155-164.
2010 Jan 14
Decker M, Si YG, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors." Journal of medicinal chemistry.. 2010 Jan 14; 53(1):402-18.
2009 Apr 15
Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, Ganorkar R, VanAlstine MA, Guo C, Cohen DJ, Bidlack JM. "Syntheses of novel high affinity ligands for opioid receptors." Bioorganic & medicinal chemistry letters. 2009 Apr 15; 19(8):2289-94. Epub 2009 Feb 25.
2009 Jan 15
Wentland MP, Lu Q, Ganorkar R, Zhang SZ, Jo S, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine." Bioorganic & medicinal chemistry letters. 2009 Jan 15; 19(2):365-8. Epub 2008 Nov 24.
2009 Jan 1
Wentland MP, Lou R, Lu Q, Bu Y, VanAlstine MA, Cohen DJ, Bidlack JM. "Syntheses and opioid receptor binding properties of carboxamido-substituted opioids." Bioorganic & medicinal chemistry letters. 2009 Jan 1; 19(1):203-8. Epub 2008 Nov 07.
2009 Jan
Bidlack JM, Morris HH. "Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism." Seizure : the journal of the British Epilepsy Association. 2009 Jan; 18(1):79-81. Epub 2008 Aug 03.
2009
Decker M, Fulton BS, Zhang B, Knapp BI, Bidlack JM, Neumeyer JL. "Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands." Journal of medicinal chemistry.. 2009 52(23):7389-96.
2009
Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R. "Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice." Advances in experimental medicine and biology. 2009 611:495-6.
2008 Nov 19
Mathews JL, Smrcka AV, Bidlack JM. "A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Nov 19; 28(47):12183-9.
2008 Oct
Mathews JL, Fulton BS, Negus SS, Neumeyer JL, Bidlack JM. "In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties." Neurochemical research. 2008 Oct; 33(10):2142-50. Epub 2008 Jun 05.
2008 Aug 15
Fulton BS, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors." Bioorganic & medicinal chemistry letters. 2008 Aug 15; 18(16):4474-6. Epub 2008 Jul 17.
2008 May 15
Wentland MP, Sun X, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine." Bioorganic & medicinal chemistry. 2008 May 15; 16(10):5653-64. Epub 2008 Mar 30.
2008 May
Reed B, Bidlack JM, Chait BT, Kreek MJ. "Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid." Journal of neuroendocrinology.. 2008 May; 20(5):606-16. Epub 2008 Mar 15.
2007 Jun 15
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors." Bioorganic & medicinal chemistry. 2007 Jun 15; 15(12):4106-12. Epub 2007 Mar 30.
2007 May 31
Zhang A, Li F, Ding C, Yao Q, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol." Journal of medicinal chemistry.. 2007 May 31; 50(11):2747-51. Epub 2007 May 09.
2007 May 3
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors." Journal of medicinal chemistry.. 2007 May 3; 50(9):2254-8. Epub 2007 Apr 04.
2007 Mar 15
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "High-affinity carbamate analogues of morphinan at opioid receptors." Bioorganic & medicinal chemistry letters. 2007 Mar 15; 17(6):1508-11. Epub 2007 Jan 17.
2007 Jan
Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. "Glycosylation improves the central effects of DAMGO." Chemical biology & drug design. 2007 Jan; 69(1):41-7.
2007
VanAlstine MA, Wentland MP, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC." Bioorganic & medicinal chemistry letters. 2007 17(23):6516-20. Epub 2007 Sep 29.
2006 Sep 7
Wentland MP, VanAlstine M, Kucejko R, Lou R, Cohen DJ, Parkhill AL, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine." Journal of medicinal chemistry.. 2006 Sep 7; 49(18):5635-9.
2006 Sep 7
Neumeyer JL, Peng X, Knapp BI, Bidlack JM, Lazarus LH, Salvadori S, Trapella C, Balboni G. "New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores." Journal of medicinal chemistry.. 2006 Sep 7; 49(18):5640-3.
2006 Aug 15
Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. "Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries." Bioorganic & medicinal chemistry letters. 2006 Aug 15; 16(16):4331-8. Epub 2006 Jun 05.
2006 Jun
Parkhill AL, Bidlack JM. "Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line." International immunopharmacology. 2006 Jun; 6(6):1013-9. Epub 2006 Feb 17.
2006 May
Sun B, Tipton CM, Bidlack JM. "The expression of prodynorphin gene is down-regulated by activation with lipopolysaccharide in U-937 macrophage cells." Journal of neuroimmunology. 2006 May; 174(1-2):52-62. Epub 2006 Feb 17.
2006 Apr 21
Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. "Differential targeting of Gbetagamma-subunit signaling with small molecules." Science.. 2006 Apr 21; 312(5772):443-6.
2006 Jan 12
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors." Journal of medicinal chemistry.. 2006 Jan 12; 49(1):256-62.
2005 Nov
Mathews JL, Peng X, Xiong W, Zhang A, Negus SS, Neumeyer JL, Bidlack JM. "Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties." The Journal of pharmacology and experimental therapeutics.. 2005 Nov; 315(2):821-7. Epub 2005 Aug 02.
2005 Sep
Zhen Z, Bradel-Tretheway B, Sumagin S, Bidlack JM, Dewhurst S. "The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro." Journal of virology.. 2005 Sep; 79(18):11914-24.
2005 May 16
Wentland MP, Sun X, Bu Y, Lou R, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine." Bioorganic & medicinal chemistry letters. 2005 May 16; 15(10):2547-51.
2005 Apr 15
Wentland MP, Lu Q, Lou R, Bu Y, Knapp BI, Bidlack JM. "Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone." Bioorganic & medicinal chemistry letters. 2005 Apr 15; 15(8):2107-10.
2005
Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ. "Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?" Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 30(12):2254-62.
2004 Jul 30
Zhen Z, Bradel-Tretheway BG, Dewhurst S, Bidlack JM. "Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors." Journal of neuroscience methods.. 2004 Jul 30; 136(2):133-9.
2004 May 15
Csutoras C, Zhang A, Bidlack JM, Neumeyer JL. "An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors." Bioorganic & medicinal chemistry. 2004 May 15; 12(10):2687-90.
2004 May
Gekker G, Hu S, Wentland MP, Bidlack JM, Lokensgard JR, Peterson PK. "Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells." The Journal of pharmacology and experimental therapeutics.. 2004 May; 309(2):600-6. Epub 2004 Feb 02.
2004 Apr 8
Zhang A, Xiong W, Hilbert JE, DeVita EK, Bidlack JM, Neumeyer JL. "2-aminothiazole-derived opioids. Bioisosteric replacement of phenols." Journal of medicinal chemistry.. 2004 Apr 8; 47(8):1886-8.
2004 Feb 6
Rusovici DE, Negus SS, Mello NK, Bidlack JM. "Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphans." European journal of pharmacology. 2004 Feb 6; 485(1-3):119-25.
2004 Jan 1
Zhang A, Xiong W, Bidlack JM, Hilbert JE, Knapp BI, Wentland MP, Neumeyer JL. "10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors." Journal of medicinal chemistry.. 2004 Jan 1; 47(1):165-74.
2004
Stevenson GW, Wentland MP, Bidlack JM, Mello NK, Negus SS. "Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys." European journal of pharmacology. 2004 506(2):133-41.
2004
Bidlack JM, Parkhill AL. "Assay of G protein-coupled receptor activation of G proteins in native cell membranes using [35S]GTP gamma S binding." Methods in molecular biology.. 2004 237:135-43.
2003 Nov 20
Neumeyer JL, Zhang A, Xiong W, Gu XH, Hilbert JE, Knapp BI, Negus SS, Mello NK, Bidlack JM. "Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors." Journal of medicinal chemistry.. 2003 Nov 20; 46(24):5162-70.
2003 Oct
Zhou Q, Duan WH, Cohen DJ, Bidlack JM, Wentland MP. "Synthesis and pharmacology of 8-amino-3-[(tetrahydro-2-furanyl)methyl] benzomorphan." Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Oct; 38(10):748-53.
2003 Jun 19
Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, Glick SD, Bidlack JM. "Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents." Journal of medicinal chemistry.. 2003 Jun 19; 46(13):2716-30.
2003 Jun 2
Wentland MP, Sun X, Ye Y, Lou R, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues." Bioorganic & medicinal chemistry letters. 2003 Jun 2; 13(11):1911-4.
2003 Jun
Bowen CA, Negus SS, Zong R, Neumeyer JL, Bidlack JM, Mello NK. "Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 Jun; 28(6):1125-39. Epub 2003 Mar 05.
2003 Feb 27
Wentland MP, Ye Y, Cioffi CL, Lou R, Zhou Q, Xu G, Duan W, Dehnhardt CM, Sun X, Cohen DJ, Bidlack JM. "Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines." Journal of medicinal chemistry.. 2003 Feb 27; 46(5):838-49.
2002 Nov
Negus SS, Bidlack JM, Mello NK, Furness MS, Rice KC, Brandt MR. "Delta opioid antagonist effects of buprenorphine in rhesus monkeys." Behavioural pharmacology. 2002 Nov; 13(7):557-70.
2002 Sep 20
Parkhill AL, Bidlack JM. "Several delta-opioid receptor ligands display no subtype selectivity to the human delta-opioid receptor." European journal of pharmacology. 2002 Sep 20; 451(3):257-64.
2002 Jul
Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP. "8-Carboxamidocyclazocine: a long-acting, novel benzomorphan." The Journal of pharmacology and experimental therapeutics.. 2002 Jul; 302(1):374-80.
2001 Oct 22
Neumeyer JL, Gu XH, van Vliet LA, DeNunzio NJ, Rusovici DE, Cohen DJ, Negus SS, Mello NK, Bidlack JM. "Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan." Bioorganic & medicinal chemistry letters. 2001 Oct 22; 11(20):2735-40.
2001 Sep
Suzuki S, Chuang LF, Doi RH, Bidlack JM, Chuang RY. "Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence." International immunopharmacology. 2001 Sep; 1(9-10):1733-42.
2001 Jul 9
Wentland MP, Lou R, Dehnhardt CM, Duan W, Cohen DJ, Bidlack JM. "3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties." Bioorganic & medicinal chemistry letters. 2001 Jul 9; 11(13):1717-21.
2001 May 1
Peterson PK, Gekker G, Lokensgard JR, Bidlack JM, Chang AC, Fang X, Portoghese PS. "Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes." Biochemical pharmacology.. 2001 May 1; 61(9):1145-51.
2001 Mar 12
Wentland MP, Lou R, Ye Y, Cohen DJ, Richardson GP, Bidlack JM. "8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines." Bioorganic & medicinal chemistry letters. 2001 Mar 12; 11(5):623-6.
2001 Jan
Martin-Kleiner I, Bidlack JM. "Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity." International immunopharmacology. 2001 Jan; 1(1):13-20.
2001
Bidlack JM, Abraham MK. "Mitogen-induced activation of mouse T cells increases kappa opioid receptor expression." Advances in experimental medicine and biology. 2001 493:103-10.
2000 Sep 21
Wentland MP, Duan W, Cohen DJ, Bidlack JM. "Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives." Journal of medicinal chemistry.. 2000 Sep 21; 43(19):3558-65.
2000 Sep
Bidlack JM. "Detection and function of opioid receptors on cells from the immune system." Clinical and diagnostic laboratory immunology. 2000 Sep; 7(5):719-23.
2000 Mar
Neumeyer JL, Mello NK, Negus SS, Bidlack JM. "Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse." Pharmaceutica acta Helvetiae. 2000 Mar; 74(2-3):337-44.
2000 Jan 17
Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM. "8-Aminocyclazocine analogues: synthesis and structure-activity relationships." Bioorganic & medicinal chemistry letters. 2000 Jan 17; 10(2):183-7.
2000 Jan 13
Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, Negus SS, Mello NK. "Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence." Journal of medicinal chemistry.. 2000 Jan 13; 43(1):114-22.
2000
Bidlack JM, McLaughlin JP, Wentland MP. "Partial opioids. Medications for the treatment of pain and drug abuse." Annals of the New York Academy of Sciences.. 2000 909:1-11.
2000
Bidlack JM, Jadrovski I. "Pharmacological profiles of kappa opioids. Correlation between [35S]GTP gamma S binding and cyclic AMP production." Annals of the New York Academy of Sciences.. 2000 909:264.
1999 Aug 31
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. "Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Aug 31; 96(18):10385-90.
1999 Aug
Ignatowski TA, Bidlack JM. "Differential kappa-opioid receptor expression on mouse lymphocytes at varying stages of maturation and on mouse macrophages after selective elicitation." The Journal of pharmacology and experimental therapeutics.. 1999 Aug; 290(2):863-70.
1999 Apr
McLaughlin JP, Hill KP, Jiang Q, Sebastian A, Archer S, Bidlack JM. "Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity." The Journal of pharmacology and experimental therapeutics.. 1999 Apr; 289(1):304-11.
1999 Feb
Martin-Kleiner I, Bidlack JM. "The synthetic kappa-opioid agonist (-)U50,488 does not affect calcium transport into R1.1 mouse thymoma cell line." International journal of immunopharmacology. 1999 Feb; 21(2):133-40.
1998 Jul 24
Dooley CT, Ny P, Bidlack JM, Houghten RA. "Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library." The Journal of biological chemistry.. 1998 Jul 24; 273(30):18848-56.
1998 Mar 15
Sharp BM, Roy S, Bidlack JM. "Evidence for opioid receptors on cells involved in host defense and the immune system." Journal of neuroimmunology. 1998 Mar 15; 83(1-2):45-56.
1998 Jan
Xu JY, Hill KP, Bidlack JM. "The nitric oxide/cyclic GMP system at the supraspinal site is involved in the development of acute morphine antinociceptive tolerance." The Journal of pharmacology and experimental therapeutics.. 1998 Jan; 284(1):196-201.
1998 Jan
Ignatowski TA, Bidlack JM. "Detection of kappa opioid receptors on mouse thymocyte phenotypic subpopulations as assessed by flow cytometry." The Journal of pharmacology and experimental therapeutics.. 1998 Jan; 284(1):298-306.
1998
Ignatowski TA, Bidlack JM. "Changes in kappa opioid receptor expression during maturation of mouse lymphocytes." Advances in experimental medicine and biology. 1998 437:117-24.
1997 Feb 28
Lawrence DM, Hutchinson I, Seyed-Mozaffari A, Archer S, Bidlack JM. "Fluorescent staining of kappa opioid receptors using naltrexamine derivatives and phycoerythrin." Journal of immunological methods. 1997 Feb 28; 201(2):173-81.
1997 Feb 12
McLaughlin JP, Sebastian A, Archer S, Bidlack JM. "14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists." European journal of pharmacology. 1997 Feb 12; 320(2-3):121-9.
1996 Nov
Xu JY, Seyed-Mozaffari A, Archer S, Bidlack JM. "N-cyclobutylmethyl analog of normorphinone, N-CBM-TAMO: a short-term opioid agonist and long-term Mu-selective irreversible opioid antagonist." The Journal of pharmacology and experimental therapeutics.. 1996 Nov; 279(2):539-47.
1996 Nov
Archer S, Glick SD, Bidlack JM. "Cyclazocine revisited." Neurochemical research. 1996 Nov; 21(11):1369-73.
1996 Sep
Gatch MB, Negus SS, Mello NK, Archer S, Bidlack JM. "Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys." The Journal of pharmacology and experimental therapeutics.. 1996 Sep; 278(3):1282-9.
1996 Jul 23
Chao CC, Gekker G, Hu S, Sheng WS, Shark KB, Bu DF, Archer S, Bidlack JM, Peterson PK. "kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Jul 23; 93(15):8051-6.
1996 May 10
Schultz AG, Wang A, Alva C, Sebastian A, Glick SD, Deecher DC, Bidlack JM. "Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids." Journal of medicinal chemistry.. 1996 May 10; 39(10):1956-66.
1996
Bidlack JM, Lawrence DM, Ignatowski TA. "Kappa Opioid receptors on immune cells as studied by fluorescent ligands." Advances in experimental medicine and biology. 1996 402:13-22.
1995 May
Jiang Q, Seyed-Mozaffari A, Sebastian A, Archer S, Bidlack JM. "Preventing morphine antinociceptive tolerance by irreversible mu opioid antagonists before the onset of their antagonism." The Journal of pharmacology and experimental therapeutics.. 1995 May; 273(2):680-8.
1995 Mar
Joseph DB, Bidlack JM. "The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure." The Journal of pharmacology and experimental therapeutics.. 1995 Mar; 272(3):970-6.
1995 Feb 14
Lawrence DM, el-Hamouly W, Archer S, Leary JF, Bidlack JM. "Identification of kappa opioid receptors in the immune system by indirect immunofluorescence." Proceedings of the National Academy of Sciences of the United States of America.. 1995 Feb 14; 92(4):1062-6.
1995 Jan 6
Lawrence DM, Joseph DB, Bidlack JM. "Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling." Biochemical pharmacology.. 1995 Jan 6; 49(1):81-9.
1995
McLaughlin JP, Nowak D, Sebastian A, Schultz AG, Archer S, Bidlack JM. "Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors." European journal of pharmacology. 1995 294(1):201-6.
1995
Lawrence DM, Archer S, Bidlack JM. "Identification of opioid receptors in the immune system using a novel combination of selective opioid ligands and indirect phycoerythrin immunofluorescence." Advances in experimental medicine and biology. 1995 373:17-21.
1995
Bidlack JM, Joseph DB, Lawrence DM. "Kappa opioid receptors on three related thymoma cell lines. Differences in receptor-effector coupling." Advances in experimental medicine and biology. 1995 373:23-7.
1995
Dooley CT, Kaplan RA, Chung NN, Schiller PW, Bidlack JM, Houghten RA. "Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries." Peptide research. 1995 8(3):124-37.
1994 May 27
Archer S, Seyed-Mozaffari A, Jiang Q, Bidlack JM. "14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties." Journal of medicinal chemistry.. 1994 May 27; 37(11):1578-85.
1994 Mar 15
Joseph DB, Bidlack JM. "The kappa-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site." European journal of pharmacology. 1994 Mar 15; 267(1):1-6.
1994 Mar
Jiang Q, Sebastian A, Archer S, Bidlack JM. "5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone and its corresponding N-cyclopropylmethyl analog, N-cyclopropylmethylnor-5 beta-methyl-14 beta-(p-nitrocinnamoylamino)- 7,8-dihydromorphinone: mu-selective irreversible opioid antagonists." The Journal of pharmacology and experimental therapeutics.. 1994 Mar; 268(3):1107-13.
1994
Dooley CT, Chung NN, Wilkes BC, Schiller PW, Bidlack JM, Pasternak GW, Houghten RA. "An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library." Science.. 1994 266(5193):2019-22.
1993 Oct 15
Sebastian A, Bidlack JM, Jiang Q, Deecher D, Teitler M, Glick SD, Archer S. "14 beta-[(p-nitrocinnamoyl)amino]morphinones, 14 beta-[(p-nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogues: synthesis and receptor activity." Journal of medicinal chemistry.. 1993 Oct 15; 36(21):3154-60.
1993 Sep
Lawrence DM, Bidlack JM. "The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein." The Journal of pharmacology and experimental therapeutics.. 1993 Sep; 266(3):1678-83.
1993 Aug 24
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Antinociceptive evaluation of 14 beta-(bromoacetamido)-7,8-dihydro- N(cyclopropylmethyl)-normorphinone in mice." European journal of pharmacology. 1993 Aug 24; 240(2-3):201-6.
1993 Jul 6
Bidlack JM, Kaplan RA, Subbramanian RA, Seyed-Mozaffari A, Archer S. "Affinity labeling of the mu opioid receptor in bovine striatal membranes with [3H]-14 beta-(bromoacetamido)-7,8-dihydromorphine." Biochemistry.. 1993 Jul 6; 32(26):6703-11.
1993 Mar
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Pharmacological study of 14 beta-(thioglycolamido)-7,8-dihydro-N(cyclopropylmethyl)-normor phinone (N-CPM-TAMO)." The Journal of pharmacology and experimental therapeutics.. 1993 Mar; 264(3):1021-7.
1993 Jan 5
Jiang Q, Sebastian A, Archer S, Bidlack JM. "5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone: a long-lasting mu-opioid receptor antagonist devoid of agonist properties." European journal of pharmacology. 1993 Jan 5; 230(1):129-30.
1992 Nov 2
Bidlack JM, Saripalli LD, Lawrence DM. "kappa-Opioid binding sites on a murine lymphoma cell line." European journal of pharmacology. 1992 Nov 2; 227(3):257-65.
1992 Oct
Selley DE, Bidlack JM. "Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies." The Journal of pharmacology and experimental therapeutics.. 1992 Oct; 263(1):99-104.
1992 Oct
Gucker S, Bidlack JM. "Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells." Molecular pharmacology.. 1992 Oct; 42(4):656-65.
1992 Aug
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone (TAMO) and 14 beta-(bromoacetamido)-7,8-dihydromorphinone (H2BAMO)." The Journal of pharmacology and experimental therapeutics.. 1992 Aug; 262(2):526-31.
1992
Lawrence DM, Bidlack JM. "Kappa opioid binding sites on the R1.1 murine lymphoma cell line: sensitivity to cations and guanine nucleotides." Journal of neuroimmunology. 1992 41(2):223-30.
1991
Hemmick LM, Bidlack JM. "Endorphin peptides enhance mitogen-induced T cell proliferation which has been suppressed by prostaglandins." Advances in experimental medicine and biology. 1991 288:211-4.
1990 Sep
Grandy DK, Hanneman E, Bunzow J, Shih M, Machida CA, Bidlack JM, Civelli O. "Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography." Molecular endocrinology.. 1990 Sep; 4(9):1370-6.
1990 Jan
Bidlack JM, Frey DK, Kaplan RA, Seyed-Mozaffari A, Archer S. "Affinity labeling of mu opioid receptors by sulfhydryl alkylating derivatives of morphine and morphinone." Molecular pharmacology.. 1990 Jan; 37(1):50-9.
1990
Bidlack JM, Hemmick LM. "Morphine enhancement of mitogen-induced T-cell proliferation." Progress in clinical and biological research. 1990 328:405-8.
1990
Hemmick LM, Bidlack JM. "Beta-endorphin stimulates rat T lymphocyte proliferation." Journal of neuroimmunology. 1990 29(1-3):239-48.
1989 Jul 24
Selley DE, Bidlack JM. "Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements." Brain research. 1989 Jul 24; 493(1):23-32.
1989 Jun
Hemmick LM, Bidlack JM. "Beta-endorphin suppresses rat plaque-forming cell response by a non-opioid mechanism." Journal of neuroimmunology. 1989 Jun; 23(1):67-71.
1989 May 16
Bidlack JM, Frey DK, Seyed-Mozaffari A, Archer S. "14 beta-(Bromoacetamido)morphine irreversibly labels mu opioid receptors in rat brain membranes." Biochemistry.. 1989 May 16; 28(10):4333-9.
1989
Bidlack JM, Frey DK, Seyed-Mozaffari A, Archer S. "Irreversible affinity ligands for mu opioid receptors." NIDA research monograph. 1989 95:296.
1989
Selley DE, Bidlack JM. "Cation requirement for GTP regulation of [125I]b-endorphin binding to Mu and sigma opioid receptors." NIDA research monograph. 1989 95:537-8.
1988 Aug
Tyler CB, Bidlack JM. "Inhibition of (+)[3H]SKF 10,047 binding to rat brain membranes by FAB fragments from a monoclonal antibody directed against the opioid receptor." Neurochemical research. 1988 Aug; 13(8):729-35.
1988 Jun
Selley DE, Tyler CB, Bidlack JM. "Guanine nucleotide regulation of [125I]beta-endorphin binding to rat brain membranes: monovalent cation requirement." Journal of neurochemistry. 1988 Jun; 50(6):1844-50.
1988 Feb
Bidlack JM, O'Malley WE, Schulz R. "Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor." Molecular pharmacology.. 1988 Feb; 33(2):170-7.
1987 Oct 19
Hemmick LM, Bidlack JM. "Beta-endorphin modulation of mitogen-stimulated calcium uptake by rat thymocytes." Life sciences. 1987 Oct 19; 41(16):1971-8.
1986 Jul 24
Bidlack JM, Mabie PC. "Preparation of Fab fragments from a mouse monoclonal IgM." Journal of immunological methods. 1986 Jul 24; 91(2):157-62.
1986 Jul
Rudick RA, Pallant A, Bidlack JM, Herndon RM. "Free kappa light chains in multiple sclerosis spinal fluid." Annals of neurology. 1986 Jul; 20(1):63-9.
1986
Bidlack JM, O'Malley WE. "Inhibition of mu and delta but not kappa opioid binding to membranes by Fab fragments from a monoclonal antibody directed against the opioid receptor." The Journal of biological chemistry.. 1986 261(34):15844-9.
1986
Bidlack JM. "Binding to mu and delta opioid sites but not kappa sites is inhibited by Fab fragments from a monoclonal antibody directed against the opioid receptor." NIDA research monograph. 1986 75:21-4.
1985 Oct
Rudick RA, Peter DR, Bidlack JM, Knutson DW. "Multiple sclerosis: free light chains in cerebrospinal fluid." Neurology.. 1985 Oct; 35(10):1443-9.
1985 Sep
Rudick RA, Bidlack JM, Knutson DW. "Multiple sclerosis. Cerebrospinal fluid immune complexes that bind C1q." Archives of neurology. 1985 Sep; 42(9):856-8.
1985
Bidlack JM, Denton RR. "A monoclonal antibody capable of modulating opioid binding to rat neural membranes." The Journal of biological chemistry.. 1985 260(29):15655-61.
1984 Jan 20
Harwell LW, Bolognino M, Bidlack JM, Knapp RJ, Lord EM. "A freezing method for cell fusions to distribute and reduce labor and permit more thorough early evaluation of hybridomas." Journal of immunological methods. 1984 Jan 20; 66(1):59-67.
1984
Bidlack JM, Denton RR. "A monoclonal antibody directed against an opiate binding site in rat neural membranes." Neuropeptides. 1984 5(1-3):225-8.
1983
Bidlack JM, Abood LG. "Molecular characteristics of brain opiate and nicotine receptors." Biomembranes. 1983 11:415-37.
1983
Archer S, Seyed-Mozaffari A, Osei-Gyimah P, Bidlack JM, Abood LG. "14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone." Journal of medicinal chemistry.. 1983 26(12):1775-7.
1983
Bidlack JM, Denton RR, Harwell LW. "Generating monoclonal antibodies to the opioid receptor." Life sciences. 1983 33 Suppl 1:151-4.
1982 Apr 25
Bidlack JM, Ambudkar IS, Shamoo AE. "Purification of phospholamban, a 22,000-dalton protein from cardiac sarcoplasmic reticulum that is specifically phosphorylated by cyclic AMP-dependent protein kinase." The Journal of biological chemistry.. 1982 Apr 25; 257(8):4501-6.
1982
Bidlack JM, Abood LG, Munemitsu SM, Archer S, Gala D, Kreilick RW. "Affinity labeling and purification of the opiate receptor from rat brain." Advances in biochemical psychopharmacology. 1982 33:301-9.
1981 Jan
Bidlack JM, Abood LG, Osei-Gyimah P, Archer S. "Purification of the opiate receptor from rat brain." Proceedings of the National Academy of Sciences of the United States of America.. 1981 Jan; 78(1):636-9.
1981
Abood LG, Reynolds DT, Booth H, Bidlack JM. "Sites and mechanisms for nicotine's action in the brain." Neuroscience and biobehavioral reviews. 1981 5(4):479-86.
1980 Oct 6
Abood LG, Reynolds DT, Bidlack JM. "Stereospecific 3H-nicotine binding to intact and solubilized rat brain membranes and evidence for its noncholinergic nature." Life sciences. 1980 Oct 6; 27(14):1307-14.
1980 Oct 1
Bidlack JM, Shamoo AE. "Adenosine 3',5'-monophosphate-dependent phosphorylation of a 6000 and a 22,000 dalton protein from cardiac sarcoplasmic reticulum." Biochimica et biophysica acta.. 1980 Oct 1; 632(2):310-25.
1980 Jul 28
Bidlack JM, Abood LG. "Solubilization of the opiate receptor." Life sciences. 1980 Jul 28; 27(4):331-40.
1976
Bidlack JM, Lockshin RA. "Evolution of LDH isozymes during programmed cell death." Comparative biochemistry and physiology. B, Comparative biochemistry. 1976 55(2):161-6.