Martha L. Blair, Ph.D.

Martha L. Blair, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-6655
Lab: (585) 275-3229
Fax: (585) 273-2652

Research Bio

The goal of our research program is to understand the neural and neuroendocrine mechanisms by which blood pressure and body-fluid balance are regulated. We are particularly interested in those mechanisms that restore blood pressure and volume to appropriate levels when the cardiovascular system is challenged by conditions such as blood loss. Because anesthesia alters both sympathetic nervous system and neuroendocrine responses to cardiovascular signals, the majority of our current studies are performed in conscious, unrestrained rats with chronically indwelling vascular catheters.
Our primary research focus is on neural control of the renin-angiotensin system. Renin is a proteolytic enzyme which is secreted by the kidney and results in formation of the peptide hormone angiotensin. Renin secretion increases whenever blood pressure or blood volume decreases below normal levels. Angiotensin causes blood vessels to constrict, and has multiple additional actions which serve to elevate arterial blood pressure and defend blood volume. Our research employs physiological, pharmacological, and neuroanatomical techniques to evaluate the central nervous system and peripheral autonomic pathways that regulate renin release during cardiovascular challenges such as hemorrhage.



We have recently begun to investigate the effects of the female reproductive cycle in cardiovascular regulation. The majority of cardiovascular research has been performed in male subjects. However, recent evidence suggests that estrogen and progesterone may affect multiple facets of cardiovascular regulation. Our recent studies indicate that the ability to restore blood volume after a hemorrhage is significantly affected by the female reproductive cycle. This is an ongoing topic of research.

Awards & Honors (National)

Young Investigator Award | NIH Heart Lung and Blood Institute 1978 - 1981
Sigma Xi 1969

Awards & Honors (Local)

Dean's Teaching Fellow | University of Rochester School of Medicine and Dentistry 1988 - 1991
Commendation for excellence in first-year medical teaching, University of Rochester School of Medicine and Dentistry 1987
Mellon Foundation Fellow 1985 - 1988
Manuel Goldman Award for Excellence in Medical Teaching, University of Rochester School of Medicine and Dentistry 1983
Research Career Development Award | NIH Heart Lung and Blood Institute 1982 - 1987
Commendation for excellence in first-year medical teaching, University of Rochester School of Medicine and Dentistry 1982
Commendation for excellence in first-year medical teaching, University of Rochester School of Medicine and Dentistry 1981
Mellon Foundation Fellow 1979 - 1982

Recent Journal Articles

Showing the 5 most recent journal articles. 40 available »

2011
Hsu,JW; Yasmin-Karim,S; King,M.R.; Wojciechowski,JC; Mickelsen,D.; Blair,M.L.; Ting,HJ; Ma,WL; LeeYF;. "Suppression of Prostate Cancer Cell Rolling and Adhesion to Endothelium by 1 alpha, 25-Dihydroxyvitamin D3". American Journal of Pathology. 2011; . Link
2008 Mar
Wojciechowski JC, Narasipura SD, Charles N, Mickelsen D, Rana K, Blair ML, King MR. "Capture and enrichment of CD34-positive haematopoietic stem and progenitor cells from blood circulation using P-selectin in an implantable device." British journal of haematology.. 2008 Mar; 140(6):673-81. Epub 2008 Jan 22.
2007
Blair, M.L. "Sex-based differences in physiology: what should we teach in the medical curriculum?". Adv. Physiol. Educ.. 2007; 31: 23-25. Link
2006 Sep
Blair ML, Mickelsen D. "Activation of lateral parabrachial nucleus neurons restores blood pressure and sympathetic vasomotor drive after hypotensive hemorrhage." American journal of physiology. Regulatory, integrative and comparative physiology. 2006 Sep; 291(3):R742-50. Epub 2006 Mar 30.
2006 Feb
Blair ML, Mickelsen D. "Plasma protein and blood volume restitution after hemorrhage in conscious pregnant and ovarian steroid-replaced rats." American journal of physiology. Regulatory, integrative and comparative physiology. 2006 Feb; 290(2):R425-34. Epub 2005 Sep 15.

Current Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD) - Primary

Education

PhD | Physiology & Psychology | University of Washington1974
BA | Psychology | Wellesley College1969

Post-Doctoral Training & Residency

Neuroendocrinology (Postdoctoral Sponsor: Wm. F. Ganong), Department of Physiology, University of California at San Francisco 1977