Jacob N. Finkelstein, Ph.D.

Jacob N. Finkelstein, Ph.D.

Contact Information

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 850
Rochester, NY 14642

Office: (585) 275-5948

Journal Articles

Showing all 189 journal articles available.

2014
Allen JL, Liu X, Weston D, Prince L, Oberdörster G, Finkelstein JN, Johnston CJ, Cory-Slechta DA. "Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation." Toxicological sciences : an official journal of the Society of Toxicology. 2014 140(1):160-78. Epub 2014 Apr 01.
2013
Thach CT, Finkelstein JN. "Cationic nanoparticles disrupt cellular signaling in a cholesterol dependent manner." Toxicology in vitro : an international journal published in association with BIBRA. 2013 27(4):1277-86. Epub 2012 Dec 26.
2013
"Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein." Radiation research. 2013 179(6):617-29. Epub 2013 Apr 26.
2013
Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. "Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure." International journal of radiation oncology, biology, physics. 2013 86(1):128-35. Epub 2012 Nov 27.
2013
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal irradiation sensitizes mice to delayed pulmonary challenge." Radiation research. 2013 179(4):475-84. Epub 2012 Mar 15.
2013
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration." PloS one. 2013 8(3):e59965. Epub 2013 Mar 21.
2012
O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein N, Dean DA, Lawrence BP. "Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1." The American journal of pathology. 2012 181(2):441-51. Epub 2012 Jun 05.
2012
Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data." Toxicology. 2012 297(1-3):1-9. Epub 2012 Apr 02.
2011
Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Validation of an LDH assay for assessing nanoparticle toxicity." Toxicology. 2011 287(1-3):99-104. Epub 2011 Jun 23.
2011
Wilson KM, Finkelstein JN, Blumkin AK, Best D, Klein JD. "Micronutrient levels in children exposed to secondhand tobacco smoke." Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2011 13(9):800-8. Epub 2011 May 09.
2011
Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. "Effect of total body irradiation on late lung effects: hidden dangers." International journal of radiation biology. 2011 87(8):902-13. Epub 2011 May 17.
2010
Williams JP, Johnston CJ, Finkelstein JN. "Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?" Current drug targets. 2010 11(11):1386-94.
2010
Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. "Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure." Radiation research. 2010 173(4):522-35.
2010
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G. "Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics." Journal of toxicology and environmental health. Part A. 2010 73(5):445-61.
2009
Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A. "Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells." The Journal of biological chemistry. 2009 284(31):21047-56. Epub 2009 May 29.
2009
Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J. "IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2009 29(5):273-84.
2009
Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL. "The influence of protein adsorption on nanoparticle association with cultured endothelial cells." Biomaterials. 2009 Feb;30(4):603- 10, 2009. 2009; 30(4): 603-10. Link
2009
Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL. "The influence of protein adsorption on nanoparticle association with cultured endothelial cells." Biomaterials. 2009 30(4):603-10. Epub 2008 Nov 13.
2009
Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE. "Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response." Nanotoxicology. 2009 3(4):307-318.
2009
Johnston CJ, Williams JP, Hernady E, Reed C, Finkelstein JN. "Inflammatory Cells vs Parachyma in Normal Tissue Response to Radiation Induced Lung Fibrosis." Radiation Research, In Review,. 2009; . Link
2009
Johnston CJ, Gelein R, Oberdoerster G, Finkelstein JN. "Developmental Effects of PM During Postnatal Lung Development." In preparation,. 2009; . Link
2009
Saperstein S, Huyck H, Kimball E, Johnston C, Finkelstein J, Pryhuber G. "The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice." Mediators of inflammation. 2009 2009:958658. Epub 2009 Nov 04.
2008
Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW. "Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia." The Journal of immunology : official journal of the American Association of Immunologists. 2008 181(2):1409-19.
2008
Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW. "Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia." J Immunol. 2008; 181(2): 409-19. Link
2006
Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. "A comparative dose-related response of several key pro- and anti-inflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black." J Occup Environ Med. 2006; 48(12): 1265-78. Link
2006
Oberdörster G, Finkelstein JN. "In vitro dosing of cells with poorly soluble particles." Toxicol Sci. 2006; 94(2): 439. Link
2006
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. "Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development." American journal of physiology. Lung cellular and molecular physiology. 2006 291(5):L1101-11. Epub 2006 Jul 21.
2006
Johnston CJ, Holm BA, Gelein R, Finkelstein JN. "Postnatal lung development: immediate-early gene responses post ozone and LPS exposure." Inhalation toxicology. 2006 18(11):875-83.
2006
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. "Translocation of inhaled ultrafine manganese oxide particles to the central nervous system." Environ Health Perspect. 2006; 114(8): 1178. Link
2006
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. "Translocation of inhaled ultrafine manganese oxide particles to the central nervous system." Environmental health perspectives. 2006 114(8):1172-8.
2006
Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. "Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells." American journal of physiology. Lung cellular and molecular physiology. 2006 290(6):L1087-96. Epub 2006 Jan 06.
2006
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. "p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth." The American journal of pathology. 2006 168(6):1838-47.
2006
Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J. "Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells." Am J Physiol Lung Cell Mol Physiol. 2006; 290(6): L1087-96. Link
2006
Rushton E, Finkelstein J, Oberdörster G. "Toxicological Profiles of Nanomaterials." Proc. Mat. Res. Soc. 2006; . Link
2006
Oberdörster G, Finkelstein JN. "In vitro dosing of cells with poorly soluble particles." Toxicological sciences : an official journal of the Society of Toxicology. 2006 94(2):439; author reply 440. Epub 2006 Sep 04.
2005
Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. "Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells." Journal of applied physiology. 2005 99(3):1226-32. Epub 2005 May 12.
2005
Singal M, Finkelstein JN. "Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli." Inhalation toxicology. 2005 17(9):415-25.
2005
Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. "Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors." International journal of radiation oncology, biology, physics. 2005 62(1):273-8.
2005
Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. "Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells." Infection and immunity. 2005 73(5):2766-77.
2005
Johnston CJ, Holm BA, Finkelstein JN. "Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses." Experimental lung research. 2005 31(4):431-47.
2005
Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. "Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate." Experimental lung research. 2005 31(6):527-46.
2005
Singal M, Finkelstein JN. "Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells." Experimental lung research. 2005 31(6):581-97.
2005
Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. "Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology." Toxicological sciences : an official journal of the Society of Toxicology. 2005 88(2):614-29. Epub 2005 Sep 21.
2004
Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. "Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains." Inhalation toxicology. 2004 16(6-7):461-71.
2004
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. "Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model." Radiation research. 2004 161(5):560-7.
2004
Finkelstein JN, Johnston CJ. "Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress." Pediatrics. 2004 113(4 Suppl):1092-6.
2004
Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. "Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate." Experimental lung research. 2004 30(2):105-20.
2004
D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. "Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage". Am J Physiol. 2004; 286((1)): L30-36. Link
2004
D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. "Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage." American journal of physiology. Lung cellular and molecular physiology. 2004 286(1):L30-6. Epub 2003 Aug 08.
2004
Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. "On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats." Inhalation toxicology. 2004 16 Suppl 1:41-53.
2004
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. "Inflammatory cell recruitment following thoracic irradiation." Experimental lung research. 2004 30(5):369-82.
2003
Roper JM, Staversky RJ, Finkelstein JN, Keng PC, O'Reilly MA. "Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein." American journal of physiology. Lung cellular and molecular physiology. 2003 285(3):L691-700. Epub 2003 May 09.
2003
Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. "Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth." American journal of clinical oncology. 2003 26(4):S103-9.
2003
Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. "The biological basis of a comprehensive grading system for the adverse effects of cancer treatment." Seminars in radiation oncology. 2003 13(3):182-8.
2003
Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. "Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release." Inflammation. 2003 27(3):137-45.
2003
Pryhuber GS, Huyck HL, Baggs R, Oberdörster G, Finkelstein JN. "Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice." Toxicological sciences : an official journal of the Society of Toxicology. 2003 72(1):150-7.
2003
O'Reilly MA, Staversky RJ, Finkelstein JN, Keng PC. "Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia." American journal of physiology. Lung cellular and molecular physiology. 2003 284(2):L368-75. Epub 2002 Oct 11.
2003
Williams JP, Hernady E, Levitt M, Johnston C, Reed C, Okunieff P, Finkelstein JN. "Role of the recruited bone marrow-derived alveolar macrophage and the chemokine receptor, CCR2, in the development of pulmonary late radiation effects in a mouse model." Int J Radiat Oncol Biol Phys. 2003; 57((2 Suppl)): S162-S163. Link
2002
Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. "Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses." Experimental lung research. 2002 28(6):419-33.
2002
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. "Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families." Radiation research. 2002 157(3):256-65.
2002
Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. "Radiation pneumonitis and early circulatory cytokine markers." Seminars in radiation oncology. 2002 12(1 Suppl 1):26-33.
2002
Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM. "Transforming growth factor alpha (TGF(alpha)) is increased during hyperoxia and fibrosis." Experimental lung research. 2002 28(5):361-72.
2002
D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA. "Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants." Biology of the neonate. 2002 82(3):145-9.
2001
Johnston CJ, Oberdörster G, Finkelstein JN. "Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures." Inhalation toxicology. 2001 13(8):689-702.
2001
O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC. "The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress." American journal of respiratory cell and molecular biology. 2001 24(6):703-10.
2000
Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G. "Pulmonary effects induced by ultrafine PTFE particles." Toxicology and applied pharmacology. 2000 168(3):208-15.
2000
Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN. "Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung." American journal of respiratory and critical care medicine. 2000 162(4 Pt 1):1342-7.
2000
Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. "Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica." Toxicological sciences : an official journal of the Society of Toxicology. 2000 56(2):405-13.
2000
Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. "Acute pulmonary effects of ultrafine particles in rats and mice." Research report (Health Effects Institute). 2000 (96):5-74; disc. 75-86.
2000
Chess PR, Toia L, Finkelstein JN. "Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells." American journal of physiology. Lung cellular and molecular physiology. 2000 279(1):L43-51.
2000
Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN. "Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice." Inhalation toxicology. 2000 12(3):187-203.
2000
Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. "Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin." Inhalation toxicology. 2000 12(3):205-24.
2000
Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. "Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice." Inhalation toxicology. 2000 12(3):225-43.
2000
Pryhuber GS, Huyck HL, Staversky RJ, Finkelstein JN, O'Reilly MA. "Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2." American journal of respiratory cell and molecular biology. 2000 22(2):150-6.
2000
Elder ACP, Gelein R, Finkelstein JN, Cox C, Oberdorster G. "Endotoxin priming affects the lung response to ultrafine particles and ozone in young and old rats". Inhal Tox. 2000; 12((Suppl 1)): 85-98. Link
2000
D'Angio CT, Finkelstein JN. "Oxygen regulation of gene expression: a study in opposites." Molecular genetics and metabolism. 2000 71(1-2):371-80.
2000
Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. "Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin." Inhalation toxicology. 2000 12 Suppl 4:227-46.
1999
Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG. "Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia." The Journal of clinical investigation. 1999 104(9):1307-17.
1999
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure." Toxicology and applied pharmacology. 1999 158(3):211-20.
1999
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. "Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation." Infection and immunity. 1999 67(7):3452-60.
1999
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress." The American journal of physiology. 1999 276(6 Pt 1):L979-88.
1999
Charafeddine L, D'Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM. "Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung." The American journal of physiology. 1999 276(1 Pt 1):L105-13.
1999
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line." Toxicology and applied pharmacology. 1999 161(2):111-22.
1999
Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR. "Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin." Experimental lung research. 1999 25(1):7-21.
1999
Johnston CJ, Stripp BR, Reynolds SD, Avissar NE, Reed CK, Finkelstein JN. "Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures." Experimental lung research. 1999 25(1):81-97.
1998
Okunieff P, Wang X, Rubin P, Finkelstein JN, Constine LS, Ding I. "Radiation-induced changes in bone perfusion and angiogenesis." International journal of radiation oncology, biology, physics. 1998 42(4):885-9.
1998
Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR. "Clara cell secretory protein deficiency increases oxidant stress response in conducting airways." The American journal of physiology. 1998 275(2 Pt 1):L348-56.
1998
Daly HE, Baecher-Allan CM, Paxhia AT, Ryan RM, Barth RK, Finkelstein JN. "Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment." Laboratory investigation; a journal of technical methods and pathology. 1998 78(4):393-400.
1998
Adawi A, Zhang Y, Baggs R, Finkelstein J, Phipps RP. "Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome." The American journal of pathology. 1998 152(3):651-7.
1998
O'Reilly MA, Staversky RJ, Stripp BR, Finkelstein JN. "Exposure to hyperoxia induces p53 expression in mouse lung epithelium." American journal of respiratory cell and molecular biology. 1998 18(1):43-50.
1998
Johnston CJ, Stripp BR, Piedboeuf B, Wright TW, Mango GW, Reed CK, Finkelstein JN. "Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury". Exper Lung Res. 1998; 24((2)): 189-202. Link
1998
Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein JN, Phipps RP. "Blockage of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis". Clin Immunol Immunopath. 1998; 89((3)): 222-230. Link
1998
Oberdoerster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein JN. "Ambient ultrafine particle: inducers of acute lung injury". Exp Tox Pathol. 1998; . Link
1998
Johnston CJ, Finkelstein JN, Gelein R, Oberdoerster G. "Pulmonary inflammatory responses and cytokine and antioxidant mRNA levels in the lungs of young and old C57BL/6 mice after exposure to teflon fumes." Inh Tox 10. 1998; 10((10)): 931-953. Link
1998
Chess PR, Ryan RM, Finkelstein JN. "H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-alpha." Experimental lung research. 1998 24(1):27-39.
1998
Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN. "Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury." Experimental lung research. 1998 24(2):189-202.
1998
Johnston CJ, Wright TW, Rubin P, Finkelstein JN. "Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation." Experimental lung research. 1998 24(3):321-37.
1998
D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN. "Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia." Experimental lung research. 1998 24(5):685-702.
1998
Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. "Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis." Clinical immunology and immunopathology. 1998 89(3):222-30.
1998
Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. "Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha." The American journal of physiology. 1998 275(6 Pt 1):L1110-9.
1998
Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G. "Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice." Toxicological sciences : an official journal of the Society of Toxicology. 1998 46(2):300-7.
1997
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN. "Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice." American journal of respiratory cell and molecular biology. 1997 17(4):491-500.
1997
Finkelstein JN, Johnston C, Barrett T, Oberdörster G. "Particulate-cell interactions and pulmonary cytokine expression." Environmental health perspectives. 1997 105 Suppl 5:1179-82.
1997
Johnston CJ, Mango GW, Finkelstein JN, Stripp BR. "Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice." American journal of respiratory cell and molecular biology. 1997 17(2):147-55.
1997
D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM. "Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis." The American journal of physiology. 1997 272(4 Pt 1):L720-30.
1997
Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN. "Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung." Toxicology and applied pharmacology. 1997 142(2):303-10.
1997
O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN. "Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen." The American journal of physiology. 1997 272(1 Pt 1):L60-7.
1997
Schurmann WHT, Frampton MW, Schurmann G, Roberts NJ, Nicols JE, Finkelstein JN, Oberdoerster G, Utell MJ. "A flow cytometric assay of Fc receptor-mediated phagocytosis". J Aerosol Med. 1997; 10((1)): 1-11. Link
1997
Johnston CJ, Wright TW, Reed CK, Finkelstein JN. "Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia." Experimental lung research. 1997 23(6):537-52.
1996
Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G. "Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure." Toxicology and applied pharmacology. 1996 140(1):154-63.
1996
Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. "Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation." Radiation research. 1996 145(6):762-7.
1996
Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD. "Ultrafine particles as a potential environmental health hazard. Studies with model particles." Chest. 1996 109(3 Suppl):68S-69S.
1996
Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ. "Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells." The American journal of physiology. 1996 270(2 Pt 1):L173-82.
1995
Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH. "Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury." American journal of respiratory cell and molecular biology. 1995 13(4):377-86.
1995
Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. "A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis." International journal of radiation oncology, biology, physics. 1995 33(1):99-109.
1995
Wagner CL, Ryan RM, Forsythe DE, Keenan A, Finkelstein JN. "Secretion of transforming growth factor-alpha (TGF alpha) by postnatal rabbit alveolar macrophages." Pediatric research. 1995 38(1):49-54.
1995
Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN. "Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis." Radiation research. 1995 142(2):197-203.
1995
D'Angio CT, Sinkin RA, LoMonaco MB, Finkelstein JN. "Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung." The American journal of physiology. 1995 268(5 Pt 1):L826-31.
1995
Opanashuk LA, Finkelstein JN. "Induction of newly synthesized proteins in astroglial cells exposed to lead." Toxicology and applied pharmacology. 1995 131(1):21-30.
1995
Sinkin RA, Sanders RS, Horowitz S, Finkelstein JN, Lomonaco MB. "Cell-specific expression of fibronectin in adult and developing rabbit lung." Pediatric research. 1995 37(2):189-95.
1995
Opanashuk LA, Finkelstein JN. "Relationship of lead-induced proteins to stress response proteins in astroglial cells." Journal of neuroscience research. 1995 42(5):623-32.
1994
Chess PR, Ryan RM, Finkelstein JN. "Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation." Pediatric research. 1994 36(4):481-6.
1994
Finkelstein JN, Johnston CJ, Baggs R, Rubin P. "Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis." International journal of radiation oncology, biology, physics. 1994 28(3):621-31.
1994
Ryan RM, Mineo-Kuhn MM, Kramer CM, Finkelstein JN. "Growth factors alter neonatal type II alveolar epithelial cell proliferation." The American journal of physiology. 1994 266(1 Pt 1):L17-22.
1994
Widzowski DV, Finkelstein JN, Pokora MJ, Cory-Slechta DA. "Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity." Neurotoxicology. 1994 15(4):853-65.
1993
McDonald S, Rubin P, Chang AY, Penney DP, Finkelstein JN, Grossberg S, Feins R, Gregory PK. "Pulmonary changes induced by combined mouse beta-interferon (rMuIFN-beta) and irradiation in normal mice--toxic versus protective effects." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 1993 26(3):212-8.
1992
Sinkin RA, LoMonaco MB, Finkelstein JN, Watkins RH, Cox C, Horowitz S. "Increased fibronectin mRNA in alveolar macrophages following in vivo hyperoxia." American journal of respiratory cell and molecular biology. 1992 7(5):548-55.
1992
Finkelstein JN, Horowitz S, Sinkin RA, Ryan RM. "Cellular and molecular responses to lung injury in relation to induction of tissue repair and fibrosis." Clinics in perinatology. 1992 19(3):603-20.
1992
Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. "Role of the alveolar macrophage in lung injury: studies with ultrafine particles." Environmental health perspectives. 1992 97:193-9.
1992
Brandes ME, Finkelstein JN. "Alteration of Type II Pneumocyte Proliferation by Alveolar Macrophage-Derived Growth Factors". Exp Cell Res (Suppl). 1992; 198: 321-327. Link
1992
Brandes ME, Finkelstein JN, Shapiro DL. "Alveolar Macrophage Production of Type II Cell Growth Modulators Following In Vivo Hyperoxia". Exp Lung Res (Suppl). 1992; 18: 173-180. Link
1992
Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein JN. "Role of the alveolar macrophage in lung injury. Studies with ultrafine particles". Env Health Perspec. 1992; 97: 193-199. Link
1992
McBride JT, Kirchner KK, Russ G, Finkelstein J. "Role of pulmonary blood flow in postpneumonectomy lung growth." Journal of applied physiology. 1992 73(6):2448-51.
1992
Rubin P, Finkelstein J, Shapiro D. "Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblast." International journal of radiation oncology, biology, physics. 1992 24(1):93-101.
1992
Oberdörster G, Ferin J, Finkelstein J, Soderholm S. "Thermal degradation events as health hazards: particle vs gas phase effects, mechanistic studies with particles." Acta astronautica. 1992 27:251-6.
1991
Lehnert BE, Dethloff LA, Finkelstein JN, van der Kogel AJ. "Temporal sequence of early alterations in rat lung following thoracic X-irradiation." International journal of radiation biology. 1991 60(4):657-75.
1991
Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE. "Mechanisms of nitrogen dioxide toxicity in humans." Research report (Health Effects Institute). 1991 (43):1-33.
1990
Brandes ME, Finkelstein JN. "The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury." Toxicology letters. 1990 54(1):3-22; discussion 1-2.
1990
Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ. "Changes in gene expression in hyperoxia-induced neonatal lung injury." The American journal of physiology. 1990 258(2 Pt 1):L107-11.
1990
Oberdörster G, Ferin J, Finkelstein J, Wade P, Carson N. "Increased pulmonary toxicity of ultrafine particles? II. Lung lavage studies". J Aerosol Sci. 1990; 21: 384-391. Link
1990
Finkelstein JN. "Physiologic and toxicologic responses of alveolar type II cells." Toxicology. 1990 60(1-2):41-52.
1989
Shapiro DL, Finkelstein JN, Van Diver T. "Isolation of alveolar epithelial cells from lung tissue obtained at autopsy." In vitro cellular & developmental biology : journal of the Tissue Culture Association. 1989 25(11):1051-4.
1989
Rubin P, McDonald S, Maasilta P, Finkelstein JN, Shapiro DL, Penney D, Gregory PK. "Serum markers for prediction of pulmonary radiation syndromes. Part I: Surfactant apoprotein." International journal of radiation oncology, biology, physics. 1989 17(3):553-8.
1989
Brandes ME, Finkelstein JN. "Stimulated rabbit alveolar macrophages secrete a growth factor for type II pneumocytes." American journal of respiratory cell and molecular biology. 1989 1(2):101-9.
1989
Maniscalco WM, Finkelstein JN, Parkhurst AB. "Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells." Experimental lung research. 1989 15(3):473-89.
1989
Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ. "Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro." Environmental research. 1989 48(2):179-92.
1989
Robey-Bond SM, Mavis RD, Finkelstein JN. "Radiolabeling microsomes in vitro with Tritiated Alpha-Tocopherol". Ann NY Acad Sci. 1989; 570: 511-513. Link
1989
Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ. "Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans." American journal of respiratory cell and molecular biology. 1989 1(6):499-505.
1989
Hendricks-Muñoz KD, Finkelstein JN, Shapiro DL. "Membrane phospholipid methylation is associated with surfactant secretion in rabbit type II alveolar epithelial cells." Experimental lung research. 1989 15(1):63-76.
1989
Brandes ME, Finkelstein JN. "Induction of the stress response by isolation of rabbit type II pneumocytes." Experimental lung research. 1989 15(1):93-111.
1988
Holm BA, Matalon S, Finkelstein JN, Notter RH. "Type II pneumocyte changes during hyperoxic lung injury and recovery." Journal of applied physiology. 1988 65(6):2672-8.
1987
Aschner M, Rodier PM, Finkelstein JN. "Increased axonal transport in the rat optic system after systemic exposure to methylmercury: differential effects in local vs systemic exposure conditions." Brain research. 1987 401(1):132-41.
1987
Jacobs AJ, Berg GG, Finkelstein JN. "Inhibition of reaggregation of isolated cerebellar neurons by methylmercury and the kinetics of reversal by exogenous serum albumin". In Vitro Toxicol. 1987; 1: 219-231. Link
1986
Aschner M, Rodier PM, Finkelstein JN. "Reduction of axonal transport in the rat optic system after direct application of methylmercury." Brain research. 1986 381(2):244-50.
1986
Leary JF, Finkelstein JN, Notter RH, Shapiro DL. "A quantitative study of the development of type II pneumocytes in fetal lung." Cytometry. 1986 7(5):431-8.
1986
Rubin P, Finkelstein JN, Siemann DW, Shapiro DL, Van Houtte P, Penney DP. "Predictive biochemical assays for late radiation effects." International journal of radiation oncology, biology, physics. 1986 12(4):469-76.
1986
Sichak SP, Mavis RD, Finkelstein JN, Clarkson TW. "An examination of the oxidation of mercury vapor by rat brain homogenate." Journal of biochemical toxicology. 1986 1(1):53-68.
1986
Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN. "Insulin receptors and insulin effects on type II alveolar epithelial cells." Biochimica et biophysica acta. 1986 885(2):216-20.
1986
Notter RH, Penney DP, Finkelstein JN, Shapiro DL. "Adsorption of natural lung surfactant and phospholipid extracts related to tubular myelin formation." Pediatric research. 1986 20(1):97-101.
1986
Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN. "In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat." Radiation research. 1986 105(1):97-104.
1986
Jacobs AJ, Maniscalco WM, Finkelstein JN. "Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells." Toxicology and applied pharmacology. 1986 86(3):362-71.
1985
Holm BA, Notter RH, Finkelstein JN. "Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids." Chemistry and physics of lipids. 1985 38(3):287-98.
1985
Finkelstein JN, Ghosh S. "The effect of lateral mobility on the binding and reaction rate at membrane sites." Physiological chemistry and physics and medical NMR. 1985 17(1):77-9.
1985
Maniscalco WM, Finkelstein JN, Parkhurst AB. "Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants." Pediatric research. 1985 19(12):1272-7.
1984
Fraser CM, Venter JC, Finkelstein JN, Shapiro DL. "Monoclonal antibodies to surface antigens of rabbit type II pneumocytes." The American review of respiratory disease. 1984 130(3):505-7.
1984
Gallo RL, Finkelstein JN, Notter RH. "Characterization of the plasma and mitochondrial membrane potentials of alveolar type II cells by the use of ionic probes." Biochimica et biophysica acta. 1984 771(2):217-27.
1984
Brasch SP, Finkelstein JN, Makhani G, Ghosh S. "Arterial influx, efflux and tissue content of albumin in rabbits in vivo." Cardiovascular research. 1984 18(4):244-8.
1984
Shapiro DL, Finkelstein JN, Rubin P, Penney DP, Siemann DW. "Radiation induced secretion of surfactant from cell cultures of type II pneumocytes: an in vitro model of radiation toxicity." International journal of radiation oncology, biology, physics. 1984 10(3):375-8.
1984
Notter RH, Finkelstein JN. "Pulmonary surfactant: an interdisciplinary approach." Journal of applied physiology: respiratory, environmental and exercise physiology. 1984 57(6):1613-24.
1984
Gallo RL, Wersto RP, Notter RH, Finkelstein JN. "Lysophosphatidylcholine cell depolarization: increased membrane permeability for use in the determination of cell membrane potentials." Archives of biochemistry and biophysics. 1984 235(2):544-54.
1983
Rubin P, Siemann DW, Shapiro DL, Finkelstein JN, Penney DP. "Surfactant release as an early measure of radiation pneumonitis." International journal of radiation oncology, biology, physics. 1983 9(11):1669-73.
1983
Notter RH, Finkelstein JN, Taubold RD. "Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface." Chemistry and physics of lipids. 1983 33(1):67-80.
1983
Finkelstein JN, Maniscalco WM, Shapiro DL. "Properties of freshly isolated type II alveolar epithelial cells." Biochimica et biophysica acta. 1983 762(3):398-404.
1983
Maniscalco WM, Finkelstein JN, Parkhurst AB. "De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells." Biochimica et biophysica acta. 1983 751(3):462-9.
1982
Wright ES, Vang MJ, Finkelstein JN, Mavis RD. "Changes in phospholipid biosynthetic enzymes in type II cells and alveolar macrophages isolated from rat lungs after NO2 exposure." Toxicology and applied pharmacology. 1982 66(2):305-11.
1982
Notter RH, Smith S, Taubold RD, Finkelstein JN. "Path dependence of adsorption behavior of mixtures containing dipalmitoyl phosphatidylcholine." Pediatric research. 1982 16(7):515-9.
1982
Shapiro DL, Finkelstein JN, Penney DP, Siemann DW, Rubin P. "Sequential effects of irradiation on the pulmonary surfactant system." International journal of radiation oncology, biology, physics. 1982 8(5):879-82.
1982
Maniscalco WM, Finkelstein JN, Parkhurst AB. "De novo fatty acid synthesis in developing rat lung." Biochimica et biophysica acta. 1982 711(1):49-58.
1982
Leary JF, Finkelstein JN, Notter RH, Shapiro DL. "Isolation of type II pneumocytes by laser flow cytometry." The American review of respiratory disease. 1982 125(3):326-30.
1982
Finkelstein JN, Shapiro DL. "Isolation of type II alveolar epithelial cells using low protease concentrations." Lung. 1982 160(2):85-98.
1981
Merritt TA, Stuard ID, Puccia J, Wood B, Edwards DK, Finkelstein J, Shapiro DL. "Newborn tracheal aspirate cytology: classification during respiratory distress syndrome and bronchopulmonary dysplasia." The Journal of pediatrics. 1981 98(6):949-56.
1981
Penney DP, Shapiro DL, Rubin P, Finkelstein JN, Siemann DW. "Effects of radiation on the mouse lung and potential induction of radiation pneumonitis". Virchows Archiv of Cell Pathol. 1981; 37: 327-336. Link
1980
Rubin P, Shapiro DL, Finklestein JN, Penney DP. "The early release of surfactant following lung irradiation of alveolar type II cells." International journal of radiation oncology, biology, physics. 1980 6(1):75-7.
1979
Finkelstein JN, Mavis RD. "Biochemical evidence for internal proteolytic damage during isolation of type II alveolar epithelial cells." Lung. 1979 156(4):243-54.
1978
Mavis RD, Finkelstein JN, Hall BP. "Pulmonary surfactant synthesis. A highly active microsomal phosphatidate phosphohydrolase in the lung." Journal of lipid research. 1978 19(4):467-77.
1977
Finkelstein JN, Carlin AS. "Treatment of an unusual adolescent bed-wetting behavior by covert sensitization. A case study." Journal of the American Academy of Child Psychiatry. 1977 16(1):159-64.
1976
Finkelstein JN, Ghosh S, Schweppe JS. "Kinetic analysis of in vivo lipoprotein flux in the normal rabbit aorta". Artery. 1976; 2: 161-173. Link
1976
Ghosh S, Finkelstein JN, Moss DB, Schweppe JS. "Evaluation of the permeability parameters (influx, efflux and volume of distribution) of arterial wall for LDL and other proteins." Advances in experimental medicine and biology. 1976 67(00):191-204.
1975
Basu MK, Finkelstein JN, Ghosh S, Schweppe JS. "Studies on the binding of 1-anilino-8-naphthalene sulfonate to very low density and high density himan serum lipoproteins." Biochimica et biophysica acta. 1975 398(3):385-93.