Edith M. Lord, Ph.D.

Edith M. Lord, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 316
Rochester, NY 14642

Journal Articles

Showing all 61 journal articles available.

2014 Jul
Martin DK, Uckermann O, Bertram A, Liebner C, Hendruschk S, Sitoci-Ficici KH, Schackert G, Lord EM, Temme A, Kirsch M. "Differential Growth Inhibition of Cerebral Metastases by Anti-angiogenic Compounds." Anticancer research.. 2014 Jul; 34(7):3293-302.
2014 May 15
Gerber SA, Lim JY, Connolly KA, Sedlacek AL, Barlow ML, Murphy SP, Egilmez NK, Lord EM. "Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors." International journal of cancer. Journal international du cancer.. 2014 May 15; 134(10):2383-92. Epub 2013 Nov 11.
2014 Apr 29
Xu Y, Hyun YM, Lim K, Lee H, Cummings RJ, Gerber SA, Bae S, Cho TY, Lord EM, Kim M. "Optogenetic control of chemokine receptor signal and T-cell migration." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Apr 29; 111(17):6371-6. Epub 2014 Apr 14.
2013 Oct
Sedlacek AL, Gerber SA, Randall TD, van Rooijen N, Frelinger JG, Lord EM. "Generation of a dual-functioning antitumor immune response in the peritoneal cavity." The American journal of pathology.. 2013 Oct; 183(4):1318-28. Epub 2013 Aug 08.
2011 Oct 28
Valentino MD, Abdul-Alim CS, Maben ZJ, Skrombolas D, Hensley LL, Kawula TH, Dziejman M, Lord EM, Frelinger JA, Frelinger JG. "A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens." Journal of immunological methods.. 2011 Oct 28; 373(1-2):111-26. Epub 2011 Aug 18.
2010 Feb 15
Sorensen EW, Gerber SA, Frelinger JG, Lord EM. "IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Feb 15; 184(4):1858-66. Epub 2010 Jan 08.
2009 Jun
Cummings RJ, Mitra S, Foster TH, Lord EM. "Migration of skin dendritic cells in response to ionizing radiation exposure." Radiation research.. 2009 Jun; 171(6):687-97.
2009
Lord EM. "Immunology at the university of Rochester." Immunologic research. 2009 45(2-3):97-9. Epub 2009 Feb 25.
2009
Sorensen EW, Gerber SA, Sedlacek AL, Rybalko VY, Chan WM, Lord EM. "Omental immune aggregates and tumor metastasis within the peritoneal cavity." Immunologic research. 2009 45(2-3):185-94. Epub 2009 Feb 28.
2008 Mar 1
Lugade AA, Sorensen EW, Gerber SA, Moran JP, Frelinger JG, Lord EM. "Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Mar 1; 180(5):3132-9.
2008
Cummings RJ, Mitra S, Lord EM, Foster TH. "Antibody-labeled fluorescence imaging of dendritic cell populations in vivo." Journal of biomedical optics.. 2008 13(4):044041.
2007 Feb
Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. "Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors." Human gene therapy. 2007 Feb; 18(2):93-105.
2007 Jan 27
Ramanayake T, Simon DA, Frelinger JG, Lord EM, Robert J. "In vivo study of T-cell responses to skin alloantigens in Xenopus using a novel whole-mount immunohistology method." Transplantation.. 2007 Jan 27; 83(2):159-66.
2006 Nov
Gerber SA, Rybalko VY, Bigelow CE, Lugade AA, Foster TH, Frelinger JG, Lord EM. "Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth." The American journal of pathology.. 2006 Nov; 169(5):1739-52.
2005 Jun 15
Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. "Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor." The Journal of immunology : official journal of the American Association of Immunologists.. 2005 Jun 15; 174(12):7516-23.
2005 May 1
Gerber SA, Turner MJ, Lugade AA, Moran JP, Frelinger JG, Lord EM. "Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology." The Prostate.. 2005 May 1; 63(2):105-16.
2003 Sep 20
Moran JP, Gerber SA, Martin CA, Frelinger JG, Lord EM. "Transfection of the genes for interleukin-12 into the K1735 melanoma and the EMT6 mammary sarcoma murine cell lines reveals distinct mechanisms of antitumor activity." International journal of cancer. Journal international du cancer.. 2003 Sep 20; 106(5):690-8.
2003 May 6
Gerber SA, Moran JP, Frelinger JG, Frelinger JA, Fenton BM, Lord EM. "Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts." British journal of cancer.. 2003 May 6; 88(9):1453-61.
2002 May 15
Fisher TL, Nocera M, Willis RA, Turner MJ, Abdul Alim CS, Brown DM, Bourne PA, di Sant'Agnese PA, Messing EM, Lord EM, Frelinger JG. "Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2-expressing tumors." The Prostate.. 2002 May 15; 51(3):153-65.
2001 Oct 10
Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. "Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice." Human gene therapy. 2001 Oct 10; 12(15):1867-79.
2001 Oct 1
Turner MJ, Abdul-Alim CS, Willis RA, Fisher TL, Lord EM, Frelinger JG. "T-cell antigen discovery (T-CAD) assay: a novel technique for identifying T cell epitopes." Journal of immunological methods.. 2001 Oct 1; 256(1-2):107-19.
2001 Sep 1
Fenton BM, Lord EM, Paoni SF. "Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models." International journal of cancer. Journal international du cancer.. 2001 Sep 1; 93(5):693-8.
2001 Apr
Brown DM, Fisher TL, Wei C, Frelinger JG, Lord EM. "Tumours can act as adjuvants for humoral immunity." Immunology. 2001 Apr; 102(4):486-97.
2001 Feb
Fenton BM, Lord EM, Paoni SF. "Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival." Radiation research.. 2001 Feb; 155(2):360-8.
2000 Feb
Lee J, Moran JP, Fenton BM, Koch CJ, Frelinger JG, Keng PC, Lord EM. "Alteration of tumour response to radiation by interleukin-2 gene transfer." British journal of cancer.. 2000 Feb; 82(4):937-44.
2000 Jan
Fenton BM, Lord EM, Paoni SF. "Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation." Radiation research.. 2000 Jan; 153(1):75-83.
1999 May
Storozynsky E, Woodward JG, Frelinger JG, Lord EM. "Interleukin-3 and granulocyte-macrophage colony-stimulating factor enhance the generation and function of dendritic cells." Immunology. 1999 May; 97(1):138-49.
1999 Feb
Fenton BM, Paoni SF, Lee J, Koch CJ, Lord EM. "Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements." British journal of cancer.. 1999 Feb; 79(3-4):464-71.
1998 Oct
Wei C, Callahan BP, Turner MJ, Willis RA, Lord EM, Barth RK, Frelinger JG. "Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes." International journal of molecular medicine.. 1998 Oct; 2(4):487-96.
1998 Jun 15
Yeh KY, McAdam AJ, Pulaski BA, Shastri N, Frelinger JG, Lord EM. "IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Jun 15; 160(12):5773-80.
1998 May
Lord EM, Yeh KY, Moran JA, Storozynsky E, Frelinger JG. "IL-3-mediated enhancement of particulate antigen presentation by macrophages." Journal of immunotherapy (Hagerstown, Md. : 1997). 1998 May; 21(3):205-10.
1998 Apr 1
Lee J, Fenton BM, Koch CJ, Frelinger JG, Lord EM. "Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment." Cancer research.. 1998 Apr 1; 58(7):1478-85.
1998 Apr
Lord EM, Frelinger JG. "Tumor immunotherapy: cytokines and antigen presentation." Cancer immunology, immunotherapy : CII.. 1998 Apr; 46(2):75-81.
1998 Feb
Willis RA, Wei C, Turner MJ, Callahan BP, Pugh AE, Barth RK, Lord EM, Frelinger JG. "A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer (Review)." International journal of molecular medicine.. 1998 Feb; 1(2):379-86.
1998
Fenton BM, Paoni SF, Koch CJ, Lord EM. "Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia." Advances in experimental medicine and biology. 1998 454:619-28.
1997 Jun 10
Wei C, Willis RA, Tilton BR, Looney RJ, Lord EM, Barth RK, Frelinger JG. "Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy." Proceedings of the National Academy of Sciences of the United States of America.. 1997 Jun 10; 94(12):6369-74.
1997
Yeh KY, Chen Z, Nasir A, Ohsuga Y, Takashima A, Lord EM, Gaspari AA. "Expression of B7-1 by Pam 212 squamous cell carcinoma enhances tumor cell interactions with dendritic epidermal cells but does not affect in vivo tumor growth." The Journal of investigative dermatology.. 1997 109(6):728-33.
1997
Koch CJ, Lord EM, Shapiro IM, Clyman RI, Evans SM. "Imaging hypoxia and blood flow in normal tissues." Advances in experimental medicine and biology. 1997 428:585-93.
1996 Jul 29
Lee J, Siemann DW, Koch CJ, Lord EM. "Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts." International journal of cancer. Journal international du cancer.. 1996 Jul 29; 67(3):372-8.
1996 Jul
Wei C, Storozynsky E, McAdam AJ, Yeh KY, Tilton BR, Willis RA, Barth RK, Looney RJ, Lord EM, Frelinger JG. "Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes." Cancer immunology, immunotherapy : CII.. 1996 Jul; 42(6):362-8.
1996 Apr 16
Pulaski BA, Yeh KY, Shastri N, Maltby KM, Penney DP, Lord EM, Frelinger JG. "Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Apr 16; 93(8):3669-74.
1996 Jan 1
Woods ML, Koch CJ, Lord EM. "Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole, EF5, and monoclonal antibodies." International journal of radiation oncology, biology, physics.. 1996 Jan 1; 34(1):93-101.
1995 Oct 15
McAdam AJ, Pulaski BA, Storozynsky E, Yeh KY, Sickel JZ, Frelinger JG, Lord EM. "Analysis of the effect of cytokines (interleukins 2, 3, 4, and 6, granulocyte-monocyte colony-stimulating factor, and interferon-gamma) on generation of primary cytotoxic T lymphocytes against a weakly immunogenic tumor." Cellular immunology.. 1995 Oct 15; 165(2):183-92.
1995 Oct 15
Yeh KY, Pulaski BA, Woods ML, McAdam AJ, Gaspari AA, Frelinger JG, Lord EM. "B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma." Cellular immunology.. 1995 Oct 15; 165(2):217-24.
1995 May 29
McAdam AJ, Pulaski BA, Harkins SS, Hutter EK, Lord EM, Frelinger JG. "Synergistic effects of co-expression of the TH1 cytokines IL-2 and IFN-gamma on generation of murine tumor-reactive cytotoxic cells." International journal of cancer. Journal international du cancer.. 1995 May 29; 61(5):628-34.
1994 Apr
McAdam AJ, Felcher A, Woods ML, Pulaski BA, Hutter EK, Frelinger JG, Lord EM. "Transfection of transforming growth factor-beta producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes." Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 1994 Apr; 15(3):155-64.
1993 Nov
McAdam AJ, Yeh KY, Pulaski BA, Frelinger JG, Lord EM. "Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2." Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 1993 Nov; 14(4):293-7.
1993 May 1
Pulaski BA, McAdam AJ, Hutter EK, Biggar S, Lord EM, Frelinger JG. "Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism." Cancer research.. 1993 May 1; 53(9):2112-7.
1993
Lord EM, Harwell L, Koch CJ. "Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts." Cancer research.. 1993 53(23):5721-6.
1993
Chen Z, Rosten SI, Lord EM, Gaspari AA. "Murine Pam 212 cutaneous squamous cell carcinoma is nonimmunogenic in normal syngeneic hosts and resistant to immune effector mechanisms." Regional immunology. 1993 5(5):285-92.
1993
Woods ML, McAdam AJ, Frelinger JG, Lord EM. "Isolation and expansion of tumor-infiltrating lymphocytes." BioTechniques. 1993 15(6):970-2.
1992 Sep
McAdam AJ, Blieden TM, Frelinger JG, Lord EM. "CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4+CD8+ cytotoxic T cell clone." European journal of immunology.. 1992 Sep; 22(9):2461-4.
1992 Feb 15
Cerosaletti KM, Woodward JG, Lord EM, Frelinger JG. "Two regions of the H-2 Dd promoter are responsive to dimethylsulfoxide in line 1 cells by a mechanism distinct from IFN-gamma." The Journal of immunology : official journal of the American Association of Immunologists.. 1992 Feb 15; 148(4):1212-21.
1991 Aug 15
Blieden TM, McAdam AJ, Frelinger JG, Lord EM. "Mechanism of cytolytic T lymphocyte killing of a low class I-expressing tumor." The Journal of immunology : official journal of the American Association of Immunologists.. 1991 Aug 15; 147(4):1433-8.
1991
Blieden TM, McAdam AJ, Foresman MD, Cerosaletti KM, Frelinger JG, Lord EM. "Class-I MHC expression in the mouse lung carcinoma, line 1: a model for class-I inducible tumors." International journal of cancer. Supplement = Journal international du cancer. Supplement. 1991 6:82-9.
1990 May
Cerosaletti KM, Blieden TM, Harwell LW, Welsh KM, Frelinger JG, Lord EM. "Alteration of the metastatic potential of line 1 lung carcinoma cells: opposite effects of class I antigen induction by interferons versus DMSO or gene transfection." Cellular immunology.. 1990 May; 127(2):299-310.
1989 Oct 1
Wilson KM, Siegal G, Lord EM. "Tumor necrosis factor-mediated cytotoxicity by tumor-associated macrophages." Cellular immunology.. 1989 Oct 1; 123(1):158-65.
1989 Apr 4
Liu YC, Marraccino RL, Keng PC, Bambara RA, Lord EM, Chou WG, Zain SB. "Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle." Biochemistry.. 1989 Apr 4; 28(7):2967-74.
1988 Jun 1
Bahler DW, Cerosaletti KM, Lord EM, Frelinger JG. "Molecular analysis of deficient class I H-2 antigen expression by mouse lung carcinoma cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1988 Jun 1; 140(11):4003-12.
1987 Nov
Loeffler DA, Keng PC, Wilson KM, Lord EM. "Comparison of fluorescence intensity of Hoechst 33342-stained EMT6 tumour cells and tumour-infiltrating host cells." British journal of cancer.. 1987 Nov; 56(5):571-6.
1987
Marraccino RL, Wahl AF, Keng PC, Lord EM, Bambara RA. "Cell cycle dependent activities of DNA polymerases alpha and delta in Chinese hamster ovary cells." Biochemistry.. 1987 26(24):7864-70.

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