Ingrid H. Sarelius, Ph.D.

Ingrid H. Sarelius, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-7729
Fax: (585) 273-2652

Research Bio

My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Since cardiovascular disease is a major killer of adult populations, and since much of this is vascular disease or disorder, understanding normal blood vessel function seems like a good place to start.
The major tool that we use to ask our questions is confocal immunofluorescent intravital microscopy; we are one of a handful of labs worldwide that is able to image local events in cells of the vascular wall in real time in blood perfused microvessels in living animals.

We also use single microparticle tracking to define the local fluid dynamic environment in vivo, and confocal imaging of signaling molecules and leukocyte populations in the in situ blood vessel.

Recent Journal Articles

Showing the 5 most recent journal articles. 77 available »

2012 Nov
Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, Glading AJ. "Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo." Arteriosclerosis, thrombosis, and vascular biology. 2012 Nov; 32(11):2702-10. Epub 2012 Aug 23.
2012 Jul 2
Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. "Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels." The Journal of experimental medicine. 2012 Jul 2; 209(7):1349-62. Epub 2012 Jun 18.
2011 Oct
Sumagin R, Kuebel JM, Sarelius IH. "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1." American journal of physiology. Cell physiology. 2011 Oct; 301(4):C804-13. Epub 2011 Jun 08.
2010 Aug
Sarelius I, Pohl U. "Control of muscle blood flow during exercise: local factors and integrative mechanisms." Acta physiologica (Oxford, England). 2010 Aug; 199(4):349-65. Epub 2010 Mar 26.
2010 May 1
Sumagin R, Sarelius IH. "Intercellular adhesion molecule-1 enrichment near tricellular endothelial junctions is preferentially associated with leukocyte transmigration and signals for reorganization of these junctions to accommodate leukocyte passage." The Journal of immunology : official journal of the American Association of Immunologists. 2010 May 1; 184(9):5242-52. Epub 2010 Apr 02.

Current Appointments

Professor (Part-Time) - Department of Pharmacology and Physiology (SMD) - Primary
Professor (Part-Time) - Department of Biomedical Engineering (SMD)

Education

PhD | Physiology | University of Auckland, New Zealand1978
MSc(Hons) | Physiology | Massey University1972
BSc | Physiology | Massey University1968