David R. Williams, Ph.D.

David R. Williams, Ph.D.

Contact Information

Dean for Research of Arts, Science, & Engineering
William G. Allyn Professor of Medical Optics
317 Latttimore Hall
Rochester, NY 14627

Office: (585) 275-8672
Administrative: (585) 275-6049
Office: (585) 276-6070
Fax: (585) 271-3043
Fax: (585) 275-3480

Research Bio

We use adaptive optics, the same technique used by astronomers to take clear pictures of the sky through the earth's turbulent atmosphere, to explore the organization and function of the retina and the optical and neural limits on human vision. Just as atmospheric turbulence distorts light arriving from distant stars, imperfections in the eye's cornea and lens distort light passing through the eye, causing blurred images to be formed on the retina.



With adaptive optics, which uses a Shack-Hartmann wavefront sensor to measure the eye's imperfections and a deformable mirror to correct them, we can correct most of the optical aberrations in the eye, providing the eye with the best image quality ever achieved. This means we can look into the eye and see the retina more clearly than was ever possible before, even allowing us to see individual cells in the living retina, but also that we can look out from the eye and see a much sharper view of the world than ever seen before. In addition to learning more about the retina, we use adaptive optics to examine the potential for improving vision by correcting the optical aberrations of the eye, and to probe the neural limits on human vision.

Awards & Honors (National)

Member, National Academy of Sciences 2014
National Eye Institute Research and Career Development Award 1985 - 1990
National Science Foundation Graduate Fellowship 1976 - 1979

Awards & Honors (Local)

Association for Research in Vision and Ophthalmology Distinguished Service Award 2015
Edridge Green Medal, The Royal College of Ophthalmologists 2013
Champalimaud Vision Award 2012
Gold Fellow, Association for Research in Vision and Ophthalmology 2012
Robert M. Boynton Lecture, OSA Fall Vision Meeting, University of Washington 2009
Silver Fellow, Association for Research in Vision and Ophthalmology 2009
Rochester Business Journal Health Care Achievement Award for Innovation 2008
Bressler Prize, Jewish Guild for the Blind 2007
Honorary Doctor of Science, The State University of New York, State College of Optometry 2007
Fellow, American Association for the Advancement of Science 2006
Friedenwald Award, Association for Research in Vision and Ophthalmology 2006
University of Rochester Center for Electronic Imaging Systems Technology Transfer Award 2004
Archie Mahan Prize, Optical Society of America 2004
Founders Award, Wavefront Congress, San Francisco, CA 2003
R&D 100 Award for the MEMS-based Adaptive Optics Phoropter, given by R&D Magazine 2003
Best of What's New Award in the Medical Technology category for the Zyoptix laser vision correction system 2001
Honorary Doctor of Science, Denison University 2001
Semifinalist for Discover Award for Technological Innovation 1998
Tillyer Medal, Optical Society of America 1998
William G. Allyn Professor of Medical Optics at the Institute of Optics, University of Rochester 1997 - Present
John Simon Guggenheim Memorial Fellowship 1997 - 1998
Fellow, Optical Society of America 1992 - Present
University of Rochester Mentor Award, for excellence in teaching, research, and service to the University 1987 - 1988
Distinguished Scientific Award for an Early Contribution to Psychology, American Psychological Association 1986
Bell Laboratories Postdoctoral Fellowship 1979 - 1980
Association for Research in Vision and Ophthalmology Travel Fellowship 1977
Psychology Student Fellow, Denison University 1974

Patents

Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 08/772,977
Filed Date: December 23, 1996
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/071,794
Filed Date: May 4, 1998
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/346,309
Filed Date: July 2, 1999
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 58062/98
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/628,690
Filed Date: July 28, 2000
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 2275762
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 10-529067
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 10/078,163
Filed Date: February 20, 2002
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,588
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,589
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,591
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,590
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.:
Filed Date: January 1, 1899
Title: General
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 11/199,174
Filed Date: August 9, 2005
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,265
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,264
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,302
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,345
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: DE97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: GB97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: FR97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 09/421,892
Filed Date: October 21, 1999
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 09/533,809
Filed Date: March 24, 2000
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 2001-531011
Filed Date: October 20, 2000
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 10/125,436
Filed Date: April 19, 2002
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.:
Filed Date: January 1, 1899
Title: Legal Ref 687.00258A
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 09/559,643
Filed Date: April 28, 2000
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 90110091
Filed Date: April 30, 2001
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 10-2002-7013851
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 010624/02
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: JP2001-579674
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 01808692.6
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 2,407,082
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 200205202-5
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 257042/01
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.:
Filed Date: January 1, 1899
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: 09/969,600
Filed Date: October 4, 2001
Title: Determination of Ocular Refraction from Wavefront Aberration Data and Design of Optimum Customized Correction
Invented by: David Williams, Antonio Guirao
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: 04100159.3
Filed Date: October 4, 2001
Title: Determination of Ocular Refraction from Wavefront Aberration Data
Invented by: David Williams, Antonio Guirao
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: GB 01977449.6
Filed Date: October 4, 2001
Title: Determine Ocular Refraction From Wavefront Aberration Data and Design of Optimum Customization Correction
Invented by: David Williams, Antonio Guirao
A Metric for Computing Subjective Sharpness From Wave Sensor Data

United States Serial NO.: 10/428,159
Filed Date: August 29, 2003
Title: Sharpness Metric for Vision Quality
Invented by: David Williams
A Metric for Computing Subjective Sharpness From Wave Sensor Data

United States Serial NO.: 11/349,104
Filed Date: February 8, 2006
Title: Sharpness Metric for Vision Quality
Invented by: David Williams
Simultaneous Image Acquisition For Removing Motion Artifacts From Low Signal Images

United States Serial NO.: 11/798,902
Filed Date: May 17, 2007
Title: Method and Apparatus for Imaging in an Eye
Invented by: David Williams, Jessica Wolfing Morgan, Daniel Gray, Alfredo Dubra
Simultaneous Image Acquisition For Removing Motion Artifacts From Low Signal Images

United States Serial NO.: 13/461,880
Filed Date: May 2, 2012
Title: Method and Apparatus for Imaging in an Eye
Invented by: David Williams, Jessica Wolfing Morgan, Daniel Gray, Alfredo Dubra
Application of Structured Illumination for In-Vivo Human Retinal Imaging

United States Serial NO.: 12/100,723
Filed Date: April 10, 2008
Title: Structured Illumination for Imaging or Stationary and Non-Stationary, Fluorescent and Non-Fluorescent Objects
Invented by: David Williams, James Fienup, Sapna Shroff
Lens, Methods, and Applications

United States Serial NO.: 14/054,962
Filed Date: October 16, 2013
Title: Tunable Achromatizing Optical Apparatus, Methods, and Applications
Invented by: Robin Sharma, Yusufu Sulai, Ying Geng, Jennifer Hunter, David Williams

Recent Journal Articles

Showing the 5 most recent journal articles. 64 available »

2014 Nov
Masella BD, Hunter JJ, Williams DR. "Rod photopigment kinetics after photodisruption of the retinal pigment epithelium." Investigative ophthalmology & visual science. 2014 Nov; 55(11):7535-44. Epub 2014 Oct 14.
2014 Nov
Masella BD, Hunter JJ, Williams DR. "New wrinkles in retinal densitometry." Investigative ophthalmology & visual science. 2014 Nov; 55(11):7525-34. Epub 2014 Oct 14.
2014 Sep 1
Yang Q, Zhang J, Nozato K, Saito K, Williams DR, Roorda A, Rossi EA. "Closed-loop optical stabilization and digital image registration in adaptive optics scanning light ophthalmoscopy." Biomedical optics express. 2014 Sep 1; 5(9):3174-91. Epub 2014 Aug 26.
2014 Jul
Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. "Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye." Nature medicine. 2014 Jul; 20(7):785-9. Epub 2014 Jun 22.
2014 Jul
Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. "Endogenous fluorophores enable two-photon imaging of the primate eye." Investigative ophthalmology & visual science. 2014 Jul; 55(7):4438-47. Epub 2014 Jun 26.

Current Appointments

Professor - Department of Brain/Cognitive Sciences RC (RC)
Professor - Department of Ophthalmology (SMD)

Education

Postdoctoral Research Associate | Bell Laboratories1980
PhD | Psychology | University of California, San Diego1979
MA | Psychology | University of California, San Diego1976
BS | Psychology | Denison University1975