Research Bio
We use adaptive optics, the same technique used by astronomers to take clear pictures of the sky through the earth's turbulent atmosphere, to explore the organization and function of the retina and the optical and neural limits on human vision. Just as atmospheric turbulence distorts light arriving from distant stars, imperfections in the eye's cornea and lens distort light passing through the eye, causing blurred images to be formed on the retina.
With adaptive optics, which uses a Shack-Hartmann wavefront sensor to measure the eye's imperfections and a deformable mirror to correct them, we can correct most of the optical aberrations in the eye, providing the eye with the best image quality ever achieved. This means we can look into the eye and see the retina more clearly than was ever possible before, even allowing us to see individual cells in the living retina, but also that we can look out from the eye and see a much sharper view of the world than ever seen before. In addition to learning more about the retina, we use adaptive optics to examine the potential for improving vision by correcting the optical aberrations of the eye, and to probe the neural limits on human vision.
2010 Aug 1
Shroff SA, Fienup JR, Williams DR. "Lateral superresolution using a posteriori phase shift estimation for a moving object: experimental results." Journal of the Optical Society of America. A, Optics, image science,
and vision. 2010 Aug 1; 27(8):1770-82. |
2009 Mar
Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. "In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic." Investigative ophthalmology & visual science. 2009 Mar 0; 50(3):1350-9. Epub 2008 Oct 24. |
2009 Feb
Shroff SA, Fienup JR, Williams DR. "Phase-shift estimation in sinusoidally illuminated images for lateral superresolution." Journal of the Optical Society of America. A, Optics, image science,
and vision. 2009 Feb 0; 26(2):413-24. |
2009
Geng Y, Greenberg KP, Wolfe R, Gray DC, Hunter JJ, Dubra A, Flannery JG, Williams DR, Porter J. "In vivo imaging of microscopic structures in the rat retina." Investigative ophthalmology & visual science. 2009 50(12):5872-9. Epub 2009 Jul 02. |
2009
Morgan JI, Hunter JJ, Merigan WH, Williams DR. "The reduction of retinal autofluorescence caused by light exposure." Investigative ophthalmology & visual science. 2009 50(12):6015-22. Epub 2009 Jul 23. |
