David R. Williams, Ph.D.

David R. Williams, Ph.D.

Contact Information

University of Rochester
500 Joseph C. Wilson Blvd.
Box 270268
Rochester, NY 14611

Office: (585) 275-8672

Research Bio

We use adaptive optics, the same technique used by astronomers to take clear pictures of the sky through the earth's turbulent atmosphere, to explore the organization and function of the retina and the optical and neural limits on human vision. Just as atmospheric turbulence distorts light arriving from distant stars, imperfections in the eye's cornea and lens distort light passing through the eye, causing blurred images to be formed on the retina.



With adaptive optics, which uses a Shack-Hartmann wavefront sensor to measure the eye's imperfections and a deformable mirror to correct them, we can correct most of the optical aberrations in the eye, providing the eye with the best image quality ever achieved. This means we can look into the eye and see the retina more clearly than was ever possible before, even allowing us to see individual cells in the living retina, but also that we can look out from the eye and see a much sharper view of the world than ever seen before. In addition to learning more about the retina, we use adaptive optics to examine the potential for improving vision by correcting the optical aberrations of the eye, and to probe the neural limits on human vision.

Patents

Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 08/772,977
Filed Date: December 23, 1996
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/071,794
Filed Date: May 4, 1998
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/346,309
Filed Date: July 2, 1999
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 58062/98
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 09/628,690
Filed Date: July 28, 2000
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 2275762
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 10-529067
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 10/078,163
Filed Date: February 20, 2002
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,588
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,589
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,591
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 90/006,590
Filed Date: April 4, 2003
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.:
Filed Date: January 1, 1899
Title: General
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 11/199,174
Filed Date: August 9, 2005
Title: Method and Apparatus for Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,265
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,264
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,302
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: 12/145,345
Filed Date: June 24, 2008
Title: Method and Apparatus Improving Vision and the Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: DE97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: GB97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

United States Serial NO.: FR97954229.7
Filed Date: December 23, 1997
Title: Apparatus for Improving Vision and Resolution of Retinal Images
Invented by: David Williams, Junzhong Liang
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 09/421,892
Filed Date: October 21, 1999
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 09/533,809
Filed Date: March 24, 2000
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 2001-531011
Filed Date: October 20, 2000
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: 10/125,436
Filed Date: April 19, 2002
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.:
Filed Date: January 1, 1899
Title: Legal Ref 687.00258A
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Rapid, Automatic Measurement of the Eye's Wave Aberration

United States Serial NO.: PCT/US00/28973
Filed Date: October 20, 2000
Title: Rapid, Automatic Measurement of the Eye's Wave Aberration
Invented by: David Williams, Heidi Hofer, Pablo Artal, Juan Aragon, Pedro Prieto, Fernando Vargas, William Vaughn III, Benjamin Singer, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 09/559,643
Filed Date: April 28, 2000
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 90110091
Filed Date: April 30, 2001
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 10-2002-7013851
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 010624/02
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: P2001-579674
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 01808692.6
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: CA 2407082
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 200205202-5
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.: 257042/01
Filed Date: April 16, 2001
Title: Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
Method to Optimize the Optical Quality of the Eye in Polychromatic Light

United States Serial NO.:
Filed Date: January 1, 1899
Title: Apparatus and Method for Improving Vision and Retinal Imaging
Invented by: David Williams, Antonio Guirao, Geunyoung Yoon
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: 09/969,600
Filed Date: October 4, 2001
Title: Determination of Ocular Refraction from Wavefront Aberration Data and Design of Optimum Customized Correction
Invented by: David Williams, Antonio Guirao
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: 04100159.3
Filed Date: October 4, 2001
Title: Determination of Ocular Refraction from Wavefront Aberration Data
Invented by: David Williams, Antonio Guirao
An Objective Method to Determine the Ocular Refraction from Wavefront Aberration Data and to Design an Optimum Customized Correction of a Set of a Few Higher-Order Aberrations

United States Serial NO.: GB 01977449.6
Filed Date: October 4, 2001
Title: Determine Ocular Refraction From Wavefront Aberration Data and Design of Optimum Customization Correction
Invented by: David Williams, Antonio Guirao
A Metric for Computing Subjective Sharpness From Wave Sensor Data

United States Serial NO.: 10/428,159
Filed Date: August 29, 2003
Title: Sharpness Metric for Vision Quality
Invented by: David Williams
A Metric for Computing Subjective Sharpness From Wave Sensor Data

United States Serial NO.: 11/349,104
Filed Date: February 8, 2006
Title: Sharpness Metric for Vision Quality
Invented by: David Williams
Simultaneous Image Acquisition For Removing Motion Artifacts From Low Signal Images

United States Serial NO.: 11/798,902
Filed Date: May 17, 2007
Title: Method and Apparatus for Imaging in an Eye
Invented by: David Williams, Jessica Wolfing Morgan, Daniel Gray, Alfredo Dubra
Simultaneous Image Acquisition For Removing Motion Artifacts From Low Signal Images

United States Serial NO.: 13/461,880
Filed Date: May 2, 2012
Title: Method and Apparatus for Imaging in an Eye
Invented by: David Williams, Jessica Wolfing Morgan, Daniel Gray, Alfredo Dubra
Application of Structured Illumination for In-Vivo Human Retinal Imaging

United States Serial NO.: 12/100,723
Filed Date: April 10, 2008
Title: Structured Illumination for Imaging or Stationary and Non-Stationary, Fluorescent and Non-Fluorescent Objects
Invented by: David Williams, James Fienup, Sapna Shroff

Recent Journal Articles

Showing the 5 most recent journal articles. 48 available »

2010 Aug 1
Shroff SA, Fienup JR, Williams DR. "Lateral superresolution using a posteriori phase shift estimation for a moving object: experimental results." Journal of the Optical Society of America. A, Optics, image science, and vision.. 2010 Aug 1; 27(8):1770-82.
2009 Mar
Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. "In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic." Investigative ophthalmology & visual science.. 2009 Mar; 50(3):1350-9. Epub 2008 Oct 24.
2009 Feb
Shroff SA, Fienup JR, Williams DR. "Phase-shift estimation in sinusoidally illuminated images for lateral superresolution." Journal of the Optical Society of America. A, Optics, image science, and vision.. 2009 Feb; 26(2):413-24.
2009
Geng Y, Greenberg KP, Wolfe R, Gray DC, Hunter JJ, Dubra A, Flannery JG, Williams DR, Porter J. "In vivo imaging of microscopic structures in the rat retina." Investigative ophthalmology & visual science.. 2009 50(12):5872-9. Epub 2009 Jul 02.
2009
Morgan JI, Hunter JJ, Merigan WH, Williams DR. "The reduction of retinal autofluorescence caused by light exposure." Investigative ophthalmology & visual science.. 2009 50(12):6015-22. Epub 2009 Jul 23.

Current Appointments

Director - Center for Visual Science A&S (RC)
Professor - Department of Brain/Cognitive Sciences RC (RC)
Professor - Department of Ophthalmology (SMD)

Education

PhD | Psychology | Univ of Cal San Diego1979
MA | Psychology | Univ of Cal San Diego1976
BS | Psychology | Denison University1975