William M. Maniscalco, M.D.

William M. Maniscalco, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 275-5884
Fax: (585) 461-3614
Lab: (585) 275-1492

Journal Articles

Showing all 66 journal articles available.

2009
McCurnin, DC.; Willis, B.; Pierce, RA.; Chang, Ly.; Yoder, BA.; Yuhanna, IS.; Ballard, PA.; Pepe, JK.; Maniscalco, WM.; Crapo, JD.; Grubb, PH.; Shaul, PW. "Postnatal estradiol administration upregulates pulmonary NO synthase, improves pulmonary function, and lowers ventilatory support requirements in a primate model of neonatal chronic lung disease of Prematurity." Am J Respir Crit Care Med. 2009; .
2007 Jun
Pierce RA, Joyce B, Officer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W. "Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons." Pediatric research. 2007 Jun; 61(6):703-9.
2006 Nov
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. "Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development." American journal of physiology. Lung cellular and molecular physiology. 2006 Nov; 291(5):L1101-11. Epub 2006 Jul 21.
2006 Aug
Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. "Pathogenesis of bronchopulmonary dysplasia." Seminars in perinatology. 2006 Aug; 30(4):171-8.
2005 Sep
Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA. "Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression." Pediatric research. 2005 Sep; 58(3):549-56.
2004 May
Roper JM, Mazzatti DJ, Watkins RH, Maniscalco WM, Keng PC, O'Reilly MA. "In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells." American journal of physiology. Lung cellular and molecular physiology. 2004 May; 286(5):L1045-54. Epub 2004 Jan 16.
2004
Stevens TP, Sinkin RA, Notter RH, Wang Z, Consenstein L, Maniscalco WM. "Alternative strategies for dispensing exogenous surfactant: drug cost implications and in vitro feasibility studies". Hosp Pharm. 2004; 39((4)): 338-345. Link
2004
D'Angio CT, Maniscalco WM. "Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategies." Paediatric drugs. 2004 6(5):303-30.
2003 Oct
O'Reilly MA, Watkins RH, Staversky RJ, Maniscalco WM. "Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasia." American journal of physiology. Lung cellular and molecular physiology. 2003 Oct; 285(4):L964-71. Epub 2003 Jul 18.
2002 Nov
Maniscalco WM, Watkins RH, O'Reilly MA, Shea CP. "Increased epithelial cell proliferation in very premature baboons with chronic lung disease." American journal of physiology. Lung cellular and molecular physiology. 2002 Nov; 283(5):L991-L1001.
2002 Oct
Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. "Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)." The American journal of pathology. 2002 Oct; 161(4):1383-93.
2002 Sep
Stevens TP, Chess PR, McConnochie KM, Sinkin RA, Guillet R, Maniscalco WM, Fisher SG. "Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation." Pediatrics. 2002 Sep; 110(3):590-6.
2002 Jul 1
D'Angio CT, Maniscalco WM. "The role of vascular growth factors in hyperoxia-induced injury to the developing lung." Frontiers in bioscience : a journal and virtual library. 2002 Jul 1; 7:d1609-23. Epub 2002 Jul 01.
2002 Apr
Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H. "Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons." American journal of physiology. Lung cellular and molecular physiology. 2002 Apr; 282(4):L811-23.
2001 Nov 15
Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM. "Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia." American journal of respiratory and critical care medicine. 2001 Nov 15; 164(10 Pt 1):1971-80.
2001 May
Winkler CA, Kittelberger AM, Watkins RH, Maniscalco WM, Schwartz GJ. "Maturation of carbonic anhydrase IV expression in rabbit kidney." American journal of physiology. Renal physiology. 2001 May; 280(5):F895-903.
2000 May
Bhatt AJ, Amin SB, Chess PR, Watkins RH, Maniscalco WM. "Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung." Pediatric research. 2000 May; 47(5):606-13.
2000 Mar
Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL. "Early dexamethasone-attempting to prevent chronic lung disease." Pediatrics. 2000 Mar; 105(3 Pt 1):542-8.
2000 Mar
O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC. "p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia." American journal of physiology. Lung cellular and molecular physiology. 2000 Mar; 278(3):L552-9.
2000 Jan
Stevens TP, Sinkin RA, Hall CB, Maniscalco WM, McConnochie KM. "Respiratory syncytial virus and premature infants born at 32 weeks' gestation or earlier: hospitalization and economic implications of prophylaxis." Archives of pediatrics & adolescent medicine. 2000 Jan; 154(1):55-61.
2000
O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS. "Bcl-2 family gene expression during severe hyperoxia induced lung injury." Laboratory investigation; a journal of technical methods and pathology. 2000 80(12):1845-54.
1999 Nov
D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. "Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone." Biology of the neonate. 1999 Nov; 76(5):266-73.
1999 May
Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM. "Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury." The American journal of physiology. 1999 May; 276(5 Pt 1):L858-67.
1998 Nov
O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM. "Accumulation of p21(Cip1/WAF1) during hyperoxic lung injury in mice." American journal of respiratory cell and molecular biology. 1998 Nov; 19(5):777-85.
1998 Jun
Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL. "Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial." Pediatrics. 1998 Jun; 101(6):1006-12.
1998 Apr
Maniscalco WM, Watkins RH, Chess PR, Sinkin RA, Horowitz S, Toia L. "Cell-specific expression of fibronectin and EIIIA and EIIIB splice variants after oxygen injury." The American journal of physiology. 1998 Apr; 274(4 Pt 1):L599-609.
1997 May
Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. "Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung." American journal of respiratory cell and molecular biology. 1997 May; 16(5):557-67.
1997 Apr
Veness-Meehan KA, Moats-Staats BM, Maniscalco WM, Watkins RH, Stiles AD. "Changes in decorin expression with hyperoxic injury to developing rat lung." Pediatric research. 1997 Apr; 41(4 Pt 1):464-72.
1996 Mar
Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WW, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montgomery P. "A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome." The Journal of pediatrics. 1996 Mar; 128(3):396-406.
1996
Maniscalco WM, Watkins RH, Campbell MH. "Expression of fibronectin mRNA splice variants by rabbit lung in vivo and by alveolar type II cells in vitro." The American journal of physiology. 1996 271(6 Pt 1):L972-80.
1995 Oct
Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH. "Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury." American journal of respiratory cell and molecular biology. 1995 Oct; 13(4):377-86.
1995 Jul
D'Angio CT, Maniscalco WM, Pichichero ME. "Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations." Pediatrics. 1995 Jul; 96(1 Pt 1):18-22.
1995 May
Roberts WA, Maniscalco WM, Cohen AR, Litman RS, Chhibber A. "The use of capnography for recognition of esophageal intubation in the neonatal intensive care unit." Pediatric pulmonology. 1995 May; 19(5):262-8.
1995 Jan
Roberts WA, Maniscalco WM. "A novel cause of error in capnographic confirmation of intubation in the neonatal intensive care unit." Pediatrics. 1995 Jan; 95(1):140-2.
1994 Nov
Maniscalco WM, Sinkin RA, Watkins RH, Campbell MH. "Transforming growth factor-beta 1 modulates type II cell fibronectin and surfactant protein C expression." The American journal of physiology. 1994 Nov; 267(5 Pt 1):L569-77.
1994 Jun
Maniscalco WM, Campbell MH. "Transforming growth factor-beta induces a chondroitin sulfate/dermatan sulfate proteoglycan in alveolar type II cells." The American journal of physiology. 1994 Jun; 266(6 Pt 1):L672-80.
1994 Mar
Piedboeuf B, Maniscalco W, Hall S, Campbell M, Watkins R, Horowitz S. "In vivo and in vitro expression of metallothionein in injured type II alveolar epithelial cells." Chest. 1994 Mar; 105(3 Suppl):78S.
1993 Aug
Spafford PS, Kendig JW, Maniscalco WM. "Use of natural surfactants to prevent and treat respiratory distress syndrome." Seminars in perinatology. 1993 Aug; 17(4):285-94.
1993 Feb
Fisher DJ, Christy C, Spafford P, Maniscalco WM, Hardy DJ, Graman PS. "Neonatal Trichosporon beigelii infection: report of a cluster of cases in a neonatal intensive care unit." The Pediatric infectious disease journal. 1993 Feb; 12(2):149-55.
1993
Cohen RA, Roberts WA, Maniscalco WM. "Capnographic confirmation of endotracheal intubation". JURMC. 1993; 5((2)): 5-9. Link
1992 Sep
Maniscalco WM, Campbell MH. "Alveolar type II cells synthesize hydrophobic cell-associated proteoglycans with multiple core proteins." The American journal of physiology. 1992 Sep; 263(3 Pt 1):L348-56.
1992 Aug
Coleman RT, Sherer DM, Maniscalco WM. "Prevention of neonatal group B streptococcal infections: advances in maternal vaccine development." Obstetrics and gynecology. 1992 Aug; 80(2):301-9.
1991 Mar 28
Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ. "A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation." The New England journal of medicine. 1991 Mar 28; 324(13):865-71.
1990 Oct
Maniscalco WM, Stremmel W, Heeney-Campbell M. "Uptake of palmitic acid by rabbit alveolar type II cells." The American journal of physiology. 1990 Oct; 259(4 Pt 1):L206-12.
1989 Jul
Brown MR, Thunberg BJ, Golub L, Maniscalco WM, Cox C, Shapiro DL. "Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant." Journal of pediatric gastroenterology and nutrition. 1989 Jul; 9(1):21-7.
1989 May
Maniscalco WM, Finkelstein JN, Parkhurst AB. "Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells." Experimental lung research. 1989 May; 15(3):473-89.
1989 Jan
Maniscalco WM, Kendig JW, Shapiro DL. "Surfactant replacement therapy: impact on hospital charges for premature infants with respiratory distress syndrome." Pediatrics. 1989 Jan; 83(1):1-6.
1988 Nov
Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL. "Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials." Pediatrics. 1988 Nov; 82(5):756-62.
1987 Oct
Aschner JL, Punsalang A, Maniscalco WM, Menegus MA. "Percutaneous central venous catheter colonization with Malassezia furfur: incidence and clinical significance." Pediatrics. 1987 Oct; 80(4):535-9.
1986 Feb 21
Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN. "Insulin receptors and insulin effects on type II alveolar epithelial cells." Biochimica et biophysica acta. 1986 Feb 21; 885(2):216-20.
1986 Jan
Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN. "In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat." Radiation research. 1986 Jan; 105(1):97-104.
1986
Jacobs AJ, Maniscalco WM, Finkelstein JN. "Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells." Toxicology and applied pharmacology. 1986 86(3):362-71.
1985
Maniscalco WM, Finkelstein JN, Parkhurst AB. "Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants." Pediatric research. 1985 19(12):1272-7.
1984 Oct
Schwartz JL, Maniscalco WM, Lane AT, Currao WJ. "Twin transfusion syndrome causing cutaneous erythropoiesis." Pediatrics. 1984 Oct; 74(4):527-9.
1984 Jul
Clarke TA, Maniscalco WM, Taylor-Brown S, Roghmann KJ, Shapiro DL, Hannon-Johnson C. "Job satisfaction and stress among neonatologists." Pediatrics. 1984 Jul; 74(1):52-7.
1983 Jun 2
Finkelstein JN, Maniscalco WM, Shapiro DL. "Properties of freshly isolated type II alveolar epithelial cells." Biochimica et biophysica acta. 1983 Jun 2; 762(3):398-404.
1983 Jun
Clarke TA, Maniscalco WM, Emmens RW. "Necrotizing enterocolitis in premature infants transferred back to community hospitals." American journal of diseases of children. 1983 Jun; 137(6):563-5.
1983 May 16
Maniscalco WM, Finkelstein JN, Parkhurst AB. "De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells." Biochimica et biophysica acta. 1983 May 16; 751(3):462-9.
1983 Apr
Maniscalco WM, Shapiro DL. "Effects of dexamethasone on beta-adrenergic receptors in fetal lung explants." Pediatric research. 1983 Apr; 17(4):274-7.
1982 Sep
Maniscalco WM, Clarke TA. "Factors influencing neonatal autopsy rate." American journal of diseases of children. 1982 Sep; 136(9):781-4.
1982 Apr 15
Maniscalco WM, Finkelstein JN, Parkhurst AB. "De novo fatty acid synthesis in developing rat lung." Biochimica et biophysica acta. 1982 Apr 15; 711(1):49-58.
1980 Jun
Gross I, Smith GJ, Wilson CM, Maniscalco WM, Ingleson LD, Brehier A, Rooney SA. "The influence of hormones on the biochemical development of fetal rat lung in organ culture. II. Insulin." Pediatric research. 1980 Jun; 14(6):834-8.
1979 Jan 29
Rooney SA, Gobran LI, Marino PA, Maniscalco WM, Gross I. "Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung." Biochimica et biophysica acta. 1979 Jan 29; 572(1):64-76.
1979
Maniscalco WM, Wilson CM, Gross I. "Influence of aminophylline and cyclic AMP on glycogen metabolism in fetal rat lung in organ culture." Pediatric research. 1979 13(12):1319-22.
1978 Sep 28
Maniscalco WM, Wilson CM, Gross I, Gobran L, Rooney SA, Warshaw JB. "Development of glycogen and phospholipid metabolism in fetal and newborn rat lung." Biochimica et biophysica acta. 1978 Sep 28; 530(3):333-46.
1978 Sep
Gross I, Smith GJ, Maniscalco WM, Czajka MR, Wilson CM, Rooney SA. "An organ culture model for study of biochemical development of fetal rat lung." Journal of applied physiology: respiratory, environmental and exercise physiology. 1978 Sep; 45(3):355-62.

Books

2009
Maniscalco, WM.; Bhandari, V.. "Disruption of Lung Vascular Development in BPD". Informa Healthcare. New York: Abman (In Press), 2009.
2006
D'Angio CT, Maniscalco WM. "Vascular endothelial growth factor.". Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD. London, England: Elsevier, 2006.
2006
D'Angio CT, Maniscalco WM. "Vascular endothelial growth factor.". Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD. London, England: Elsevier, 2006. 413-418
2006
Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. "Pathogenesis of bronchopulmonary dysplasia (BPD)". Sem Perinatol. Bhandari V. : TBD, 2006.
1989
Kendig JW, Maniscalco WM, Davis JM, Notter RH, Shapiro DL. "Clinical experience with calf lung surfactant extract.". Surfactant Replacement Therapy. Shapiro DL, Notter RH. New York, NY: Alan R. Liss Inc., 1989.
1984
Maniscalco WM. "Neonatal hypoglycemia.". Assessment of the Newborn: A Guide for Diagnosis. Ziai M, Merritt TA, Clarke TA. Boston, MA: Little, Brown and Company, 1984.
1984
Maniscalco WM, Vafai J. "Neonatal hypocalcemia". Assessment of the Newborn: A Guide for Diagnosis. Ziai M, Merritt TA, Clarke TA. Boston, MA: Little, Brown and Company, 1984.
1984
Anderson VM, Maniscalco WM. "Perinatal postmortem examination". Assessment of the Newborn: A Guide for Diagnosis. Ziai M, Merritt TA, Clarke TA. Boston, MA: Little, Brown and Company, 1984.
1979
Warshaw J, Maniscalco WM. "Perinatal adaptations in carbohydrate and lipid metabolism.". Intensive Care of the Newborn. Stern L. New York, NY: Masson Press, 1979.
1978
Maniscalco WM, Warshaw J. "Cellular energy metabolism during fetal and perinatal development". Temperature Regulation and Energy Metabolism in the Newborn. Sinclair J. New York, NY: W.B. Saunders, 1978.