James Palis, M.D.

James Palis, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester, NY 14642

Office: (585) 275-5098
Fax: (585) 276-0233
Lab: (585) 275-5073
Administrative: (585) 273-2428

Research Bio

Dr. Palis' research interests are:
1) Ontogeny of the mammalian hematopoietic system,
2) Differentiation of the erythroid lineage,
3) Erythroid precursor self-renewal, and
4) Response of the hematopoietic system to ionizing radiation



Hematopoietic stem cells responsible for the production of blood cells throughout life arise during embryogenesis. However, the mechanisms that initiate blood cell development are largely unknown. The long-term aim of Dr. Palis' laboratory is to elucidate the cellular and molecular events underlying the initiation of hematopoiesis in the mammalian embryo. The first hematopoietic cells to emerge during mammalian embryogenesis are "primitive" red cells that are necessary for survival of the fetus. Their recent studies indicate that the primitive erythroid lineage in mice as "mammalian", rather than "non-mammalian" in character. Primitive erythropoiesis will thus serve as an important model of mammalian erythroid differentiation. Hematopoiesis originates in the yolk sac of embryos and transitions to the liver of the fetus. Two waves of hematopoietic progenitors have been identified in the yolk sac prior to colonization of the liver and the lineage composition and relationships of these primitive and definitive progenitor waves are under active investigation. Their studies indicate that the onset of hematopoiesis within the yolk sac of mammals is much more complex than previously thought.

The hematopoietic system of the adult is exquisitely sensitive to xenotoxic insults. The Palis laboratory is investigating the response of the erythroid and megakaryocyte lineages to ionizing radiation. These studies will provide for the rational use of cytokines and other agents to mitigate the deleterious effects of external radiation.

An understanding of the ontogeny of mammalian hematopoiesis and its reponse to damage will ultimately produce insights into the regulation and expansion of hematopoietic stem cells. These insights will also lead to a better understanding of genetic disorders, bone marrow failure syndromes and leukemias, ultimately leading to improvements in bone marrow transplantation for the curative treatment of numerous congenital anemias, genetic diseases, and several forms of childhood and adult cancers.

Awards & Honors (Local)

George Washington Goler Associate Professor of Pediatrics 2005
George Washington Goler Professor of Pediatrics 2005
University of Rochester Postdoctoral Academic Mentoring Award 1999
Second Choremion Research Award, Athens, Greece 1982

Recent Journal Articles

Showing the 5 most recent journal articles. 77 available »

2015 Jun 9
Kim AR, Olsen JL, England SJ, Huang YS, Fegan KH, Delgadillo LF, McGrath KE, Kingsley PD, Waugh RE, Palis J. "Bmi-1 Regulates Extensive Erythroid Self-Renewal." Stem cell reports. 2015 Jun 9; 4(6):995-1003. Epub 2015 May 28.
2015 Jun
Hyrien O, Peslak SA, Yanev NM, Palis J. "Stochastic modeling of stress erythropoiesis using a two-type age-dependent branching process with immigration." Journal of mathematical biology. 2015 Jun; 70(7):1485-521. Epub 2014 Jul 03.
2015 Feb
Bulger M, Palis J. "Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages." Trends in immunology. 2015 Feb; 36(2):61-2. Epub 2015 Jan 07.
2015
Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH. "The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability." Science signaling. 2015 8(372):ra34. Epub 2015 Apr 14.
2014 Aug 1
Dertinger SD, Avlasevich SL, Torous DK, Bemis JC, Phonethepswath S, Labash C, Carlson K, Mereness J, Cottom J, Palis J, Macgregor JT. "Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy." Toxicological sciences : an official journal of the Society of Toxicology. 2014 Aug 1; 140(2):307-14. Epub 2014 May 05.

Current Appointments

Professor - Department of Pediatrics, Hematology and Oncology (SMD) - Primary

Specialties

Pediatric Hematology-Oncology - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Rochester School of Medicine and Dentistry1981
BA | Biology and Hellenic Studies | University of Rochester1975

Post-Doctoral Training & Residency

Pediatric Hematology/Oncology Fellowship, University of Rochester School of Medicine and Dentistry, Rochester, NY 1988
Residency in Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 1984