Kathleen E. McGrath, Ph.D.

Kathleen E. McGrath, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester, NY 14642

Office: (585) 275-5073

Research Bio

Dr. McGrath's research interests are:



1) Emergence of hematopoiesis in murine embryo and ES/iPS cells
2) Recovery of hematopoiesis post radiation
3) Imaging flow cytometry for examination of rare populations
4) Roles of early erythroid-myeloid progenitors during embryogenesis

Dr. McGrath is a Research Assistant Professor working within Jim Palis' research group. Her research interests are in how the hematopoietic system assembled both initially in the embryo and during repair after radiation damage in the adult. She applies that paradigm to the development of the blood system in the mouse embryo where overlapping waves of stem cells emergence, each with different lineage and self-renewal potentials. Similarly, regeneration of hematopoiesis in irradiated adult bone marrow is regulated through compartments of blood cells precursors and progenitors with differential sensitivities and responses to damage. Her work relies on prospectively discriminating these cells with different potentials and understanding the signaling that has determined their fate.

Recently, Dr. McGrath has focused on a unique embryonic hematopoietic progenitor with potential for short term production of erythroid and myeloid cells that can also be identified in embryonic stem cells and can function when transfused in adults. Additionally, her studies of recovery of hematopoietic stem cells as well megakaryocytes after radiation are addressing mitigation of short term thrombocytopenia as well as long term stem cell dysfunction. These studies have benefited from her expertise in flow cytometry including pioneering the use of imaging flow cytometry in analysis of development and repair from the most primitive progenitors to mature blood cells focusing on erythroid and megakaryocyte lineages.

Recent Journal Articles

Showing the 5 most recent journal articles. 38 available »

2015 Aug
McGrath KE. "Utilization of imaging flow cytometry to define intermediates of megakaryopoiesis in vivo and in vitro." Journal of immunological methods. 2015 Aug; 423:45-51. Epub 2015 Mar 17.
2015 Jun 30
McGrath KE, Frame JM, Fegan KH, Bowen JR, Conway SJ, Catherman SC, Kingsley PD, Koniski AD, Palis J. "Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo." Cell reports. 2015 Jun 30; 11(12):1892-904. Epub 2015 Jun 18.
2015 Jun 9
Kim AR, Olsen JL, England SJ, Huang YS, Fegan KH, Delgadillo LF, McGrath KE, Kingsley PD, Waugh RE, Palis J. "Bmi-1 Regulates Extensive Erythroid Self-Renewal." Stem cell reports. 2015 Jun 9; 4(6):995-1003. Epub 2015 May 28.
2014 Aug
McGrath KE, Fegan K, Catherman S, Palis J. "Emergence of the neutrophil lineage in the mammalian embryo." Experimental hematology. 2014 Aug; 42(8 Suppl):S13.
2014 Jul 10
Niswander LM, Fegan KH, Kingsley PD, McGrath KE, Palis J. "SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury." Blood. 2014 Jul 10; 124(2):277-86. Epub 2014 Apr 15.

Education

PhD | Biology | University of Rochester1993
MS | Biology | University of Rochester1987
BA | Biology | Reed College1983