Kathleen E. McGrath, Ph.D.

Kathleen E. McGrath, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester, NY 14642

Office: (585) 275-5073

Research Bio

Dr. McGrath's research interests are:



1) Red Blood Cell transcriptome and development (Erythroid progenitor cells)
2) Blood development in the murine embryo
3) Developmental Biology
4) Molecular Biology.

Her research interest is based on a fundamental curiosity about how cells decide which fate to adopt as embryos develop. Simplistically, this involves a dynamic interplay between the potential each cell has and the signals that it receives that narrow that potential into specific fates. As part of Jim Palis' research group, she applies that paradigm to the development of the blood system in the mouse embryo.

Recently, Dr. McGrath has focused on the initial appearance of the linked fates of blood and vascular systems in the embryo and roles of signaling systems active at the time and place of these initial fate choices (e.g. Notch, BMP and Wnt signaling systems). She has also begun to examine the genetic control of later steps in the maturation of specific lineages within the blood system in the embryo versus the adult utilizing cell sorting technologies.

Recent Journal Articles

Showing the 5 most recent journal articles. 32 available »

2014 Apr 15
Niswander LM, Fegan KH, Kingsley PD, McGrath KE, Palis J. "SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady-state and following radiation injury." Blood.. 2014 Apr 15; Epub 2014 Apr 15.
2014 Apr
Niswander LM, McGrath KE, Kennedy JC, Palis J. "Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry." Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2014 Apr; 85(4):302-12. Epub 2014 Jan 16.
2013 Feb 7
Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, Stoeckert CJ, Palis J. "Ontogeny of erythroid gene expression." Blood.. 2013 Feb 7; 121(6):e5-e13. Epub 2012 Dec 12.
2013 Feb
Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM. "Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury." Stem cells.. 2013 Feb; 31(2):372-83.
2013
Frame JM, McGrath KE, Palis J. "Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells." Blood cells, molecules & diseases.. 2013 51(4):220-5. Epub 2013 Oct 02.

Current Appointments

Research Assistant Professor - Department of Pediatrics, Hematology and Oncology (SMD) - Primary
Research Assistant Professor - Center for Pediatric Biomedical Research

Education

PhD | Biology | University of Rochester1993
MS | Biology | University of Rochester1987
BA | Biology | Reed College1983