William H. Merigan, Ph.D.

William H. Merigan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 314
Rochester, NY 14642

Office: (585) 275-4872

Books

Journal Articles

Showing all 51 journal articles available.

2011 Mar
Rossi EA, Chung M, Dubra A, Hunter JJ, Merigan WH, Williams DR. "Imaging retinal mosaics in the living eye." Eye (London, England). 2011 Mar; 25(3):301-8.
2009 Mar
Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. "In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic." Investigative ophthalmology & visual science.. 2009 Mar; 50(3):1350-9. Epub 2008 Oct 24.
2009 Mar
Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA. "Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells." Nature medicine.. 2009 Mar; 15(3):285-92. Epub 2009 Feb 15.
2009
Morgan JI, Hunter JJ, Merigan WH, Williams DR. "The reduction of retinal autofluorescence caused by light exposure." Investigative ophthalmology & visual science.. 2009 50(12):6015-22. Epub 2009 Jul 23.
2009
Scoles D, Gray DC, Hunter JJ, Wolfe R, Gee BP, Geng Y, Masella BD, Libby RT, Russell S, Williams DR, Merigan WH. "In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison." BMC ophthalmology. 2009 9:9. Epub 2009 Aug 23.
2008 Aug
Morgan JI, Hunter JJ, Masella B, Wolfe R, Gray DC, Merigan WH, Delori FC, Williams DR. "Light-induced retinal changes observed with high-resolution autofluorescence imaging of the retinal pigment epithelium." Investigative ophthalmology & visual science.. 2008 Aug; 49(8):3715-29. Epub 2008 Apr 11.
2008 Jan
Gray DC, Wolfe R, Gee BP, Scoles D, Geng Y, Masella BD, Dubra A, Luque S, Williams DR, Merigan WH. "In vivo imaging of the fine structure of rhodamine-labeled macaque retinal ganglion cells." Investigative ophthalmology & visual science.. 2008 Jan; 49(1):467-73.
2007 May
Hayes RD, Merigan WH. "Mechanisms of Sensitivity Loss due to Visual Cortex Lesions in Humans and Macaques." Cerebral cortex (New York, N.Y. : 1991). 2007 May; 17(5):1117-28. Epub 2006 Jun 12.
2006 Nov
Motsinger AA, Ritchie MD, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D'Aquila RT, Johnson VA, Pollard RB, Merigan TC, Hirsch MS, Donahue JP, Kim RB, Haas DW. "Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study." Pharmacogenetics and genomics. 2006 Nov; 16(11):837-45.
2006 Sep 15
"Bridging Generations Toward an Understanding of Infectious Disease Pathogenesis, A Festschrift Honoring Thomas Merigan, 27 August 2004, Stanford, California, USA." The Journal of infectious diseases.. 2006 Sep 15; 194 Suppl 1:S1-64.
2006 Aug 7
Gray DC, Merigan W, Wolfing JI, Gee BP, Porter J, Dubra A, Twietmeyer TH, Ahamd K, Tumbar R, Reinholz F, Williams DR. "In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells." Optics express. 2006 Aug 7; 14(16):7144-58.
2006 Aug 1
Gandhi RT, Spritzler J, Chan E, Asmuth DM, Rodriguez B, Merigan TC, Hirsch MS, Shafer RW, Robbins GK, Pollard RB, . "Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384." Journal of acquired immune deficiency syndromes : JAIDS.. 2006 Aug 1; 42(4):426-34.
2005 Aug
Smith PF, Robbins GK, Shafer RW, Wu H, Yu S, Hirsch MS, Merigan TC, Park JG, Forrest A, Fischl MA, Morse GD, . "Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naive, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors." Antimicrobial agents and chemotherapy.. 2005 Aug; 49(8):3558-61.
2005 Jul 15
Campbell TB, Shulman NS, Johnson SC, Zolopa AR, Young RK, Bushman L, Fletcher CV, Lanier ER, Merigan TC, Kuritzkes DR. "Antiviral activity of lamivudine in salvage therapy for multidrug-resistant HIV-1 infection." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2005 Jul 15; 41(2):236-42. Epub 2005 Jun 07.
2005 Jul
Winters MA, Merigan TC. "Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms." Antimicrobial agents and chemotherapy.. 2005 Jul; 49(7):2575-82.
2005 May 1
Shulman NS, Delgado J, Bosch RJ, Winters MA, Johnston E, Shafer RW, Katzenstein DA, Merigan TC. "Nonnucleoside reverse transcriptase inhibitor phenotypic hypersusceptibility can be demonstrated in different assays." Journal of acquired immune deficiency syndromes : JAIDS.. 2005 May 1; 39(1):78-81.
2005 Apr
Winters MA, Kagan RM, Heseltine PN, Merigan TC. "New two-amino acid insertion near codon 70 of the HIV type 1 protease gene." AIDS research and human retroviruses.. 2005 Apr; 21(4):311-3.
2005
Haas DW, Smeaton LM, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D'Aquila RT, De Gruttola V, Pollard RB, Merigan TC, Hirsch MS, George AL, Donahue JP, Kim RB. "Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study." The Journal of infectious diseases.. 2005 192(11):1931-42. Epub 2005 Nov 01.
2005
Winters MA, Kagan RM, Kovari L, Heseltine PN, Merigan TC. "Rare one and two amino acid inserts adjacent to codon 103 of the HIV-1 reverse transcriptase (RT) affect susceptibility to non-nucleoside RT inhibitors." Antiviral therapy. 2005 10(2):363-6.
2005
Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. ""Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target." Structure (London, England : 1993). 2005 13(12):1887-95.
2004 Nov
Al Dhahry SH, Scrimgeour EM, Al Suwaid AR, Al Lawati MR, El Khatim HS, Al Kobaisi MF, Merigan TC. "Human immunodeficiency virus type 1 infection in Oman: antiretroviral therapy and frequencies of drug resistance mutations." AIDS research and human retroviruses.. 2004 Nov; 20(11):1166-72.
2004 Oct
Kagan RM, Merigan TC, Winters MA, Heseltine PN. "Increasing prevalence of HIV-1 reverse transcriptase mutation K65R correlates with tenofovir utilization." Antiviral therapy. 2004 Oct; 9(5):827-8.
2004 Aug
Merigan WH, Saunders RC. "Unilateral deficits in visual perception and learning after unilateral inferotemporal cortex lesions in macaques." Cerebral cortex (New York, N.Y. : 1991). 2004 Aug; 14(8):863-71. Epub 2004 Apr 27.
2004 Mar 15
Eron JJ, Gulick RM, Bartlett JA, Merigan T, Arduino R, Kilby JM, Yangco B, Diers A, Drobnes C, DeMasi R, Greenberg M, Melby T, Raskino C, Rusnak P, Zhang Y, Spence R, Miralles GD. "Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIV." The Journal of infectious diseases.. 2004 Mar 15; 189(6):1075-83. Epub 2004 Mar 02.
2004 Mar
Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity." Journal of virology.. 2004 Mar; 78(6):3123-32.
2004 Jan
Kagan R, Winters M, Merigan T, Heseltine P. "HIV type 1 genotypic resistance in a clinical database correlates with antiretroviral utilization." AIDS research and human retroviruses.. 2004 Jan; 20(1):1-9.
2004
Johnston E, Winters MA, Rhee SY, Merigan TC, Schiffer CA, Shafer RW. "Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance." Antimicrobial agents and chemotherapy.. 2004 48(12):4864-8.
2003 Jul 1
Shiramizu B, Theodore D, Bassett R, Coel M, Sherman KE, Glesby MJ, Chow D, Alston B, Colquhoun D, Merigan TC, Reichman RC, Berggren R, Burning WJ, Brobst S, . "Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical Trials Group." Journal of acquired immune deficiency syndromes : JAIDS.. 2003 Jul 1; 33(3):329-35.
2003 Mar
Vickrey JF, Logsdon BC, Proteasa G, Palmer S, Winters MA, Merigan TC, Kovari LC. "HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization." Protein expression and purification. 2003 Mar; 28(1):165-72.
2003
Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC, Glesby MJ, . "Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection." The Journal of infectious diseases.. 2003 188(12):1804-14. Epub 2003 Dec 09.
2003
Robbins GK, De Gruttola V, Shafer RW, Smeaton LM, Snyder SW, Pettinelli C, Dubé MP, Fischl MA, Pollard RB, Delapenha R, Gedeon L, van der Horst C, Murphy RL, Becker MI, D'Aquila RT, Vella S, Merigan TC, Hirsch MS, . "Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection." The New England journal of medicine.. 2003 349(24):2293-303.
2003
Shafer RW, Smeaton LM, Robbins GK, De Gruttola V, Snyder SW, D'Aquila RT, Johnson VA, Morse GD, Nokta MA, Martinez AI, Gripshover BM, Kaul P, Haubrich R, Swingle M, McCarty SD, Vella S, Hirsch MS, Merigan TC, . "Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection." The New England journal of medicine.. 2003 349(24):2304-15.
2003
Shimozaki SS, Hayhoe MM, Zelinsky GJ, Weinstein A, Merigan WH, Ballard DH. "Effect of parietal lobe lesions on saccade targeting and spatial memory in a naturalistic visual search task." Neuropsychologia. 2003 41(10):1365-86.
2002 Jul 1
Lobato RL, Kim EY, Kagan RM, Merigan TC. "Genotypic and phenotypic analysis of a novel 15-base insertion occurring between codons 69 and 70 of HIV type 1 reverse transcriptase." AIDS research and human retroviruses.. 2002 Jul 1; 18(10):733-6.
2002 Jun
Qari SH, Winters M, Vandamme AM, Merigan T, Heneine W. "A rapid phenotypic assay for detecting multiple nucleoside analogue reverse transcriptase inhibitor-resistant HIV-1 in plasma." Antiviral therapy. 2002 Jun; 7(2):131-9.
2002 May 24
Baxter JD, Merigan TC, Wentworth DN, Neaton JD, Hoover ML, Hoetelmans RM, Piscitelli SC, Verbiest WH, Mayers DL, . "Both baseline HIV-1 drug resistance and antiretroviral drug levels are associated with short-term virologic responses to salvage therapy." AIDS.. 2002 May 24; 16(8):1131-8.
2001 Nov
Kim EY, Winters MA, Kagan RM, Merigan TC. "Functional correlates of insertion mutations in the protease gene of human immunodeficiency virus type 1 isolates from patients." Journal of virology.. 2001 Nov; 75(22):11227-33.
2001 Oct 10
Kundu-Raychaudhuri S, Sevin A, Kilgo P, Nokta M, Pollard RB, Merigan TC. "Effect of therapeutic immunization with HIV type 1 recombinant glycoprotein 160 ImmunoAG vaccine in HIV-infected individuals with CD4+ T cell counts of >or=500 and 200-400/mm3 (AIDS Clinical Trials Group Study 246/946)." AIDS research and human retroviruses.. 2001 Oct 10; 17(15):1371-8.
2001 Aug
Winters MA, Merigan TC. "Variants other than aspartic acid at codon 69 of the human immunodeficiency virus type 1 reverse transcriptase gene affect susceptibility to nuleoside analogs." Antimicrobial agents and chemotherapy.. 2001 Aug; 45(8):2276-9.
2001 Apr
Shafer RW, Hertogs K, Zolopa AR, Warford A, Bloor S, Betts BJ, Merigan TC, Harrigan R, Larder BA. "High degree of interlaboratory reproducibility of human immunodeficiency virus type 1 protease and reverse transcriptase sequencing of plasma samples from heavily treated patients." Journal of clinical microbiology.. 2001 Apr; 39(4):1522-9.
2001 Mar 20
Kim EY, Vrang L, Oberg B, Merigan TC. "Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants." AIDS research and human retroviruses.. 2001 Mar 20; 17(5):401-7.
2000 Nov
Schooley RT, Spino C, Kuritzkes D, Walker BD, Valentine FA, Hirsch MS, Cooney E, Friedland G, Kundu S, Merigan TC, McElrath MJ, Collier A, Plaeger S, Mitsuyasu R, Kahn J, Haslett P, Uherova P, deGruttola V, Chiu S, Zhang B, Jones G, Bell D, Ketter N, Twadell T, Chernoff D, Rosandich M. "Two double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214." The Journal of infectious diseases.. 2000 Nov; 182(5):1357-64. Epub 2000 Oct 09.
2000 Nov
Winters MA, Coolley KL, Cheng P, Girard YA, Hamdan H, Kovari LC, Merigan TC. "Genotypic, phenotypic, and modeling studies of a deletion in the beta3-beta4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors." Journal of virology.. 2000 Nov; 74(22):10707-13.
2000 Sep 20
Gray CM, Lawrence J, Ranheim EA, Vierra M, Zupancic M, Winters M, Altman J, Montoya J, Zolopa A, Schapiro J, Haase AT, Merigan TC. "Highly active antiretroviral therapy results in HIV type 1 suppression in lymph nodes, increased pools of naive T cells, decreased pools of activated T cells, and diminished frequencies of peripheral activated HIV type 1-specific CD8+ T cells." AIDS research and human retroviruses.. 2000 Sep 20; 16(14):1357-69.
2000 Jul
Huxlin KR, Saunders RC, Marchionini D, Pham HA, Merigan WH. "Perceptual deficits after lesions of inferotemporal cortex in macaques." Cerebral cortex (New York, N.Y. : 1991). 2000 Jul; 10(7):671-83.
2000 Jun 16
Baxter JD, Mayers DL, Wentworth DN, Neaton JD, Hoover ML, Winters MA, Mannheimer SB, Thompson MA, Abrams DI, Brizz BJ, Ioannidis JP, Merigan TC. "A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS." AIDS.. 2000 Jun 16; 14(9):F83-93.
2000 Mar
Winters MA, Baxter JD, Mayers DL, Wentworth DN, Hoover ML, Neaton JD, Merigan TC. "Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens. The Terry Beirn Community Programs for Clinical Research on AIDS." Antiviral therapy. 2000 Mar; 5(1):57-63.
2000
Shapero MH, Kundu SK, Engleman E, Laus R, van Schooten WC, Merigan TC. "In vivo persistence of donor cells following adoptive transfer of allogeneic dendritic cells in HIV-infected patients." Cell transplantation. 2000 9(3):307-17.
2000
Kontsevich LL, Tyler CW. "Relative contributions of sustained and transient pathways to human stereoprocessing." Vision research. 2000 40(23):3245-55.
2000
Merigan WH. "Cortical area V4 is critical for certain texture discriminations, but this effect is not dependent on attention." Visual neuroscience. 2000 17(6):949-58.
1999 Aug
Merigan WH. "Sorting the wheat from the chaff in visual perception." Nature neuroscience.. 1999 Aug; 2(8):690-1.