William H. Merigan, Ph.D.

William H. Merigan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 314
Rochester, NY 14642

Office: (585) 275-4872

Professional Bio

Dr. Merigan's research examines the role of retinal ganglion cells in visual perception in the primate (human and macaque). The primate retina contains at least 14 different types of retinal ganglion cells, and each type forms a complete network across the retina. Because the size, shape andprojections of each of the cell types is distinctive, it is thought that they may play quite different and possibly independent roles invisual function,but at present relatively little is known about this question.

Some clues about possible functions of different ganglion cell classes comes from their structure (some extend across large swaths of retina, while others get input from tiny regions of retina), their physiology (some ganglion cells respond to color, while others are color blind), and their projections into the brain (some ganglion cells project to visual cortex while others reach the superchiasmatic nucleus, which is thought to be important in diurnal rhythms).

Recent Journal Articles

Showing the 5 most recent journal articles. 62 available »

2015 Feb
Kotterman MA, Yin L, Strazzeri JM, Flannery JG, Merigan WH, Schaffer DV. "Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates." Gene therapy. 2015 Feb; 22(2):116-26. Epub 2014 Dec 11.
2015 Jan 1
Yang Q, Yin L, Nozato K, Zhang J, Saito K, Merigan WH, Williams DR, Rossi EA. "Calibration-free sinusoidal rectification and uniform retinal irradiance in scanning light ophthalmoscopy." Optics letters. 2015 Jan 1; 40(1):85-8.
2014 May 7
Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH. "Imaging light responses of foveal ganglion cells in the living macaque eye." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 May 7; 34(19):6596-605.
2014 Feb
Strazzeri JM, Hunter JJ, Masella BD, Yin L, Fischer WS, Diloreto DA, Libby RT, Williams DR, Merigan WH. "Focal damage to macaque photoreceptors produces persistent visual loss." Experimental eye research. 2014 Feb; 119:88-96. Epub 2013 Dec 05.
2013 Jun 12
Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. "In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous." Science translational medicine. 2013 Jun 12; 5(189):189ra76.

Current Appointments

Professor - Department of Ophthalmology (SMD) - Primary


PhD | Psychology, All Other | Univ of Maryland1975
MS | Psychology | Univ of Maryland1972
BA | Psychology | Boston College1967