Camillo Peracchia, M.D.

Camillo Peracchia, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Professional Bio

Baccalaureate, Liceo Classico, "Istituto Zaccaria" (Milan, Italy), 1956
University of Milan, Milan, Italy, Doctor in Medicine and Surgery (M.D.), 1962
Istituto Provinçial de Obstetricia y Gynecologia, Madrid, Spain, Obstetrics and Gynecology, July 1961
University of Milan, Italy , Surgical Resident, Surgery, 1962-1964
University of Milan, Italy, Postdoctoral Fellow, Pharmacology, 1962-1966
Hopital Broussais, Paris, France, Visiting Surgeon, Cardiac Surgery, July 1965
McLean Hospital, (Harvard), Boston, MA, Research Fellow, Biophysics, 1966-1967
Harvard Medical School, Research Fellow, Neuropathology, 1966-1967
Duke University, Durham, NC, Research Associate, Anatomy, 1967-1970
Educational Council for Medical Graduates (ECFMG) Certificate Number 098-006, 1967

Research Bio

Our research has focused for several decades on the molecular mechanisms that regulate the permeability of gap junction channels. These channels mediate direct cell-to-cell exchange of small cytosolic molecules. Cell communication via gap junction channels is becoming an area of research increasingly relevant to clinical medicine. Altered cell-cell communication resulting from mutations of gap junction channel proteins (connexins), plays a key role in the X-linked Charcot-Marie-Tooth demyelinating peripheral neuropathy, hereditary non-syndromic deafness, hereditary skin disorders, and certain forms of hereditary cataract, and may be involved in the pathogenesis of cardiac arrhythmias and cancer.

Recently, we have demonstrated a functional interplay between the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and various connexin channels. The mechanism of channel regulation and gating has been studied in paired Xenopus oocytes by dual voltage-clamp electrophysiology. The molecular domains that participate in channel gating have been studied by combining molecular genetics and biophysics. The participation of calmodulin in channel gating has been suggested by data generated in oocyte pairs expressing calmodulin and connexin mutants.

Awards & Honors (Local)

Commendation for Excellence in First Year Medical School Teaching 2005
Adolph Medal for Excellence in Physiology 2004
Commendation for Excellence in First Year Medical School Teaching 2002
Commendation for Excellence in First Year Medical School Teaching 1999
Manuel D. Goldman Prize for Excellence in First-Year 1998
Commendation for Excellence in First Year Medical School Teaching 1996
Commendation for Excellence in First Year Medical School Teaching 1995
Elected Honorary Member of the Societá di Medicina e Scienze Naturali di Parma. Universitá di Parma, Italy. 1987 - Present

Recent Journal Articles

Showing the 5 most recent journal articles. 80 available »

2007 Feb
Peracchia C, Salim M, Peracchia LL. "Unusual slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant." The Journal of membrane biology. 2007 Feb; 215(2-3):161-8. Epub 2007 Jun 14.
2007
Chanson, M.; Kotsias, B.A.; Peracchia, C.; O'Grady, S.M. "Interaction of connexins with other membrane channels and transporters". Biochim. Biophys. Acta. 2007; . Link
2007
Peracchia, C.; Salim, M.; L.L. Peracchia. "Unusulal slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant". J, Membr. Biol. 2007; . Link
2005 Jun
Peracchia C, Peracchia LL. "Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50." American journal of physiology. Cell physiology. 2005 Jun; 288(6):C1381-9. Epub 2005 Jan 26.
2005 Feb
Kotsias BA, Peracchia C. "Functional interaction between CFTR and Cx45 gap junction channels expressed in oocytes." The Journal of membrane biology. 2005 Feb; 203(3):143-50.

Current Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD) - Primary

Education

MD | Medicine | Italy-Fac Med U Milan1962
Diploma di Maturita', Liceo Classico (Baccalaureate) | Insituto Zaccaria1956

Post-Doctoral Training & Residency

Research Associate. Dept.of Anatomy. Duke University, Durham, NC. 1970
Research Fellow. Biophysics. McLean Hospital. Harvard Medical School, Boston, MA 1967
Research Fellow. Neuropathology. Harvard Medical School. Boston. Mass. 1967
Visiting Surgeon. Cardiac Surgery. Hopital Broussais. Paris, France. 0
Surgical Resident. University of Milan, Italy 1964
Postdoctoral Fellow. Inst. of Pharmacology. University of Milan, Italy. 1966